| 2-Deoxy-D-Glucose Downregulates Fatty Acid Synthase Gene Expression Via an Endoplasmic Reticulum Stress-Dependent Pathway in HeLa Cells. | 2-Deoxy-D-Glucose Downregulates Fatty Acid Synthase Gene Expression Via an Endoplasmic Reticulum Stress-Dependent Pathway in HeLa Cells.
Harada N, Yoshikatsu A, Yamamoto H, Nakaya Y. | 10/8/2024 |
| Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis. | Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis.
Abdel-Hamid MS, Mansour AM, Hassan MH, Abdelhady R, Elsadek BEM, El-Sayed EM, Salama SA. | 11/7/2023 |
| Fatty acid synthase (Fasn) inhibits the expression levels of immune response genes via alteration of alternative splicing in islet cells. | Fatty acid synthase (Fasn) inhibits the expression levels of immune response genes via alteration of alternative splicing in islet cells.
Wang K, Li L, Jin J, An Y, Wang Z, Zhou S, Zhang J, Abuduaini B, Cheng C, Li N. | 05/28/2022 |
| Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension revealed by inhibition of FASN. Inhibition of FAS decreases Right ventricle hypertrophy and improves cardiac function associated with Pulmonary hypertension by perking up metabolic functions. | Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension.
Singh N, Shafiq M, Jagavelu K, Hanif K. | 07/4/2020 |
| These results support the hypothesis that IL-15 secreted from Gn-GC-C-expressing macrophages contributes to the inhibition of fatty acid synthase and lipid accumulation in adipocytes, leading to obesity resistance | Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes.
Akieda-Asai S, Ida T, Miyazato M, Kangawa K, Date Y. | 08/4/2018 |
| Calorie restriction during pregnancy modified the hepatic Fasn mRNA transcript level and altered the blood cholesterol concentrations in dams, but there were no such effects in their four-week-old offspring. | Prenatal caloric restriction alters lipid metabolism but not hepatic Fasn gene expression and methylation profiles in rats.
Nowacka-Woszuk J, Madeja ZE, Chmurzynska A., Free PMC Article | 11/4/2017 |
| The involvement of SREBP-1c and ChREBP in FASN promoter histone modification.Histone acetylation affects FASN transcription by influencing ChREBP-binding carbohydrate-responsive elements. | Histone modifications in FASN modulated by sterol regulatory element-binding protein 1c and carbohydrate responsive-element binding protein under insulin stimulation are related to NAFLD.
Du X, Cai C, Yao J, Zhou Y, Yu H, Shen W. | 06/24/2017 |
| This study showed that an associated inhibition of peroxisomal proliferator activated receptor gamma coactivator 1alpha (PGC1alpha), increased fatty acid synthase (FASN) expression in the liver, and reduced adipocyte triglyceride lipase (ATGL) expression. | Short term exendin-4 treatment reduces markers of metabolic disorders in female offspring of obese rat dams.
Chan YL, Saad S, Simar D, Oliver B, McGrath K, Reyk Dv, Bertrand PP, Gorrie C, Pollock C, Chen H. | 06/28/2016 |
| Data suggest expression of Fas in liver can be regulated by dietary components; dietary fructose up-regulates expression of Fas; supplementation with citrulline prevents up-regulation of Fas, insulin resistance, and nonalcoholic fatty liver disease. | Citrulline and Nonessential Amino Acids Prevent Fructose-Induced Nonalcoholic Fatty Liver Disease in Rats.
Jegatheesan P, Beutheu S, Ventura G, Nubret E, Sarfati G, Bergheim I, De Bandt JP. | 01/16/2016 |
| Results show that genes with the highest expression in the mammary gland, liver and adipose tissue were Elovl5, Fads2, and Fasn, respectively, in a low-lipid diet than in adequate-lipid diet. | Role of maternal tissue in the synthesis of polyunsaturated fatty acids in response to a lipid-deficient diet during pregnancy and lactation in rats.
González RS, Rodriguez-Cruz M, Maldonado J, Saavedra FJ. | 10/25/2014 |
| Pyruvate carboxylase and fatty acid synthase were knocked down in insulin cells. Insulin secretion, phospholipid and cholesterol esters were lowered. | Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells.
MacDonald MJ, Hasan NM, Dobrzyn A, Stoker SW, Ntambi JM, Liu X, Sampath H., Free PMC Article | 05/4/2013 |
| Epididymal adipose tissue expression of the fatty acid synthase (FASN) gene and NADH dehydrogenase (ubiquinone) 1beta-subcomplex 6 (NDUFB6) were significantly reduced in the high fat diet group | Weight gain induced by an isocaloric pair-fed high fat diet: a nutriepigenetic study on FASN and NDUFB6 gene promoters.
Lomba A, Martínez JA, García-Díaz DF, Paternain L, Marti A, Campión J, Milagro FI. | 01/29/2011 |
| There were reduced nuclear levels of the lipogenic transcription factor sterol regulatory element binding protein-1 in MCD-fed mice, but no consistent reduction in fatty acid synthesis genes (acetyl-CoA carboxylase and fatty acid synthase). | Hepatic free fatty acids accumulate in experimental steatohepatitis: role of adaptive pathways.
Larter CZ, Yeh MM, Haigh WG, Williams J, Brown S, Bell-Anderson KS, Lee SP, Farrell GC. | 01/21/2010 |
| Dietary soy protein, by decreasing circulating insulin levels and colon FASN expression, attenuates insulin-induced DNA damage and FASN-mediated anti-apoptosis during carcinogenesis. | Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase.
Xiao R, Su Y, Simmen RC, Simmen FA. | 01/21/2010 |
| Results describe the inhibition of fatty acid synthase by flavonoids extracted from Pangdahai (Sterculia). | The novel inhibitory effect of Pangdahai on fatty acid synthase.
Zhao WH, Zhao CY, Gao LF, Feng FF, Gao W, Chen ZL, Zhang F, Cao LG, Bi XY, Chen Y, Zhu QY, Zhang YX. | 01/21/2010 |
| PPARalpha is required to mediate the response of Scd-1 and Fas gene expression to insulin and that this is normally achieved directly by activation of LXRalpha. | Peroxisome proliferator-activated receptor alpha deficiency abolishes the response of lipogenic gene expression to re-feeding: restoration of the normal response by activation of liver X receptor alpha.
Hebbachi AM, Knight BL, Wiggins D, Patel DD, Gibbons GF. | 01/21/2010 |
| Findings establish that sequence elements previously assigned to a central structural core region of the type I fatty acid synthases and some modular polyketide synthase counterparts play an essential catalytic role as part of the dehydratase domain. | Catalytic residues are shared between two pseudosubunits of the dehydratase domain of the animal fatty acid synthase.
Pasta S, Witkowski A, Joshi AK, Smith S. | 01/21/2010 |
| Normal flux through Fasn is not required for glucose-stimulated insulin secretion. | Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion.
Joseph JW, Odegaard ML, Ronnebaum SM, Burgess SC, Muehlbauer J, Sherry AD, Newgard CB. | 01/21/2010 |
| Insulin, glucose and AICAR (an activator of AMP-activated protein kinase) affected changes in hypothalamic FAS mRNA, which may be regulated via the SREBP1c dependent or independent pathway. | Fatty acid synthase gene regulation in primary hypothalamic neurons.
Kim EK, Kleman AM, Ronnett GV., Free PMC Article | 01/21/2010 |
| polyunsaturated fatty acids decrease in vivo binding of NF-Y and SREBP-1c to the proximal promoter of the hepatic Fasn gene | Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c.
Teran-Garcia M, Adamson AW, Yu G, Rufo C, Suchankova G, Dreesen TD, Tekle M, Clarke SD, Gettys TW., Free PMC Article | 01/21/2010 |
| Transcription factors act on the promoter of the rat fatty acid synthase gene [review] | Transcription factors acting on the promoter of the rat fatty acid synthase gene.
Schweizer M, Roder K, Zhang L, Wolf SS. | 01/21/2010 |
| These observations establish for the first time that HNF-4alpha functions in vivo through a direct repeat-1 (DR-1) element in the distal FAS promoter to enhance gene transcription following refeeding of glucose to fasted rats. | Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase.
Adamson AW, Suchankova G, Rufo C, Nakamura MT, Teran-Garcia M, Clarke SD, Gettys TW., Free PMC Article | 01/21/2010 |
| Downregulated by rosiglitazone. | Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats.
Teruel T, Hernandez R, Rial E, Martin-Hidalgo A, Lorenzo M. | 01/21/2010 |
| Insulin acutely reduces hepatic FAS activity by inducing phosphorylation of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and its interaction with FAS. | Insulin acutely decreases hepatic fatty acid synthase activity.
Najjar SM, Yang Y, Fernström MA, Lee SJ, Deangelis AM, Rjaily GA, Al-Share QY, Dai T, Miller TA, Ratnam S, Ruch RJ, Smith S, Lin SH, Beauchemin N, Oyarce AM. | 01/21/2010 |
| Prolactin represses expression of transfected rat FAS in mouse adipocytes through STAT5A binding to the -908 to -893 site. | The regulation of fatty acid synthase by STAT5A.
Hogan JC, Stephens JM. | 01/21/2010 |