| JAM-A Overexpression in Human Umbilical Cord-Derived Mesenchymal Stem Cells Accelerated the Angiogenesis of Diabetic Wound By Enhancing Both Paracrine Function and Survival of Mesenchymal Stem Cells. | JAM-A Overexpression in Human Umbilical Cord-Derived Mesenchymal Stem Cells Accelerated the Angiogenesis of Diabetic Wound By Enhancing Both Paracrine Function and Survival of Mesenchymal Stem Cells.
Shu F, Lu J, Zhang W, Huang H, Lin J, Jiang L, Liu W, Liu T, Xiao S, Zheng Y, Xia Z. | 11/22/2023 |
| A Transcriptional Link between HER2, JAM-A and FOXA1 in Breast Cancer. | A Transcriptional Link between HER2, JAM-A and FOXA1 in Breast Cancer.
Cruz RGB, Madden SF, Brennan K, Hopkins AM., Free PMC Article | 04/16/2022 |
| MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer. | MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer.
Lampis A, Hahne JC, Gasparini P, Cascione L, Hedayat S, Vlachogiannis G, Murgia C, Fontana E, Edwards J, Horgan PG, Terracciano L, Sansom OJ, Martins CD, Kramer-Marek G, Croce CM, Braconi C, Fassan M, Valeri N., Free PMC Article | 03/26/2022 |
| Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation. | Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation.
Bonilha CS, Benson RA, Scales HE, Brewer JM, Garside P. | 02/5/2022 |
| LncRNA TP73-AS1 regulates miR-495 expression to promote migration and invasion of nasopharyngeal carcinoma cells through junctional adhesion molecule A. | LncRNA TP73-AS1 regulates miR-495 expression to promote migration and invasion of nasopharyngeal carcinoma cells through junctional adhesion molecule A.
Dai BQ, Jiang X, Feng LC. | 01/8/2022 |
| Association of F11R polymorphisms and gene expression with primary Sjogren's syndrome patients. | Association of F11R polymorphisms and gene expression with primary Sjögren's syndrome patients.
Fang TJ, Li RN, Lin YZ, Lin CH, Tseng CC, Sung WY, Ou TT, Wu CC, Yen JH. | 12/4/2021 |
| Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhesion molecule A and disrupts gastric epithelial integrity. | Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhesion molecule A and disrupts gastric epithelial integrity.
Marques MS, Costa AC, Osório H, Pinto ML, Relvas S, Dinis-Ribeiro M, Carneiro F, Leite M, Figueiredo C., Free PMC Article | 11/22/2021 |
| Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury. | Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury.
Yin E, Fukuhara T, Takeda K, Kojima Y, Fukuhara K, Ikejima K, Bashuda H, Kitaura J, Yagita H, Okumura K, Uchida K., Free PMC Article | 10/16/2021 |
| Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa. | Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa.
Communal L, Medrano M, Sircoulomb F, Paterson J, Köbel M, Rahimi K, Hoskins P, Tu D, Lheureux S, Oza A, Ailles L, Provencher D, Rottapel R, Mes-Masson AM. | 08/28/2021 |
| Aberrant expression of junctional adhesion molecule-A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155. | Aberrant expression of junctional adhesion molecule-A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155.
Murakami T, Takasawa A, Takasawa K, Akimoto T, Aoyama T, Magara K, Saito Y, Ota M, Kyuno D, Yamamoto S, Hasegawa T, Saito T, Osanai M., Free PMC Article | 03/6/2021 |
| Junctional Adhesion Molecules in Cancer: A Paradigm for the Diverse Functions of Cell-Cell Interactions in Tumor Progression. | Junctional Adhesion Molecules in Cancer: A Paradigm for the Diverse Functions of Cell-Cell Interactions in Tumor Progression.
Lauko A, Mu Z, Gutmann DH, Naik UP, Lathia JD., Free PMC Article | 02/13/2021 |
| Joint detection of claudin-1 and junctional adhesion molecule-A as a therapeutic target in oral epithelial dysplasia and oral squamous cell carcinoma. | Joint detection of claudin-1 and junctional adhesion molecule-A as a therapeutic target in oral epithelial dysplasia and oral squamous cell carcinoma.
Upadhaya P, Barhoi D, Giri A, Bhattacharjee A, Giri S. | 09/19/2020 |
| JAM-A rs790056 CC genotype and C allele were found to be higher in the colorectal cancer group, and approximately 3-fold increased colorectal cancer risk with CC genotype was determined. Haplotype analysis showed that GC haplotype (LFA-1 rs8058823G and JAM-A rs790056C) frequency was significantly higher in the patient group than in controls | Investigation of JAM-A (rs790056) and LFA-1 (rs8058823) gene variants in Turkish colorectal cancer patients.
Çaykara B, Alsaadoni H, Pençe HH, Pençe S, Yılmaz Aydoğan H, Taştekin D., Free PMC Article | 05/9/2020 |
| Loss of JAM-A increased the protein levels of p-FAK. | JAM-A knockdown accelerates the proliferation and migration of human keratinocytes, and improves wound healing in rats via FAK/Erk signaling.
Wang Y, Zheng J, Han Y, Zhang Y, Su L, Hu D, Fu X., Free PMC Article | 11/16/2019 |
| The authors' findings highlight a novel role of JAM-A in thyroid cancer progression and suggest that JAM-A restoration could have potential clinical relevance in thyroid cancer treatment. | Junctional adhesion molecule-A is down-regulated in anaplastic thyroid carcinomas and reduces cancer cell aggressiveness by modulating p53 and GSK3 α/β pathways.
Orlandella FM, Mariniello RM, Iervolino PLC, Auletta L, De Stefano AE, Ugolini C, Greco A, Mirabelli P, Pane K, Franzese M, Denaro M, Basolo F, Salvatore G. | 11/9/2019 |
| The observed anti-migratory activity of Ykt6 is mediated by a unique mechanism involving the expressional upregulation of microRNA 145, which selectively decreases the cellular level of Junctional Adhesion Molecule (JAM) A. | A membrane fusion protein, Ykt6, regulates epithelial cell migration via microRNA-mediated suppression of Junctional Adhesion Molecule A.
Naydenov NG, Joshi S, Feygin A, Saini S, Litovchick L, Ivanov AI., Free PMC Article | 11/9/2019 |
| hese findings support a novel mechanism by which tyrosine phosphorylation of JAM-A Y280 regulates epithelial barrier function during inflammation. | Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation.
Fan S, Weight CM, Luissint AC, Hilgarth RS, Brazil JC, Ettel M, Nusrat A, Parkos CA., Free PMC Article | 06/29/2019 |
| JAM-A was highly expressed in a small cohort of HER2+ breast cancer patients whose disease recurred following anti-HER2 therapy. High JAM-A expression also correlated with metastatic disease at the time of diagnosis in another patient cohort resistant to trastuzumab therapy. Study data suggest that increased expression and cleavage of JAM-A drive tumorigenic behavior and act as a biomarker of HER2+ breast cancer. | Cleavage of the extracellular domain of junctional adhesion molecule-A is associated with resistance to anti-HER2 therapies in breast cancer settings.
Leech AO, Vellanki SH, Rutherford EJ, Keogh A, Jahns H, Hudson L, O'Donovan N, Sabri S, Abdulkarim B, Sheehan KM, Kay EW, Young LS, Hill ADK, Smith YE, Hopkins AM., Free PMC Article | 06/8/2019 |
| Data showed that JAM-A was highly expressed in diffuse large B-cell lymphoma (DLBCL) patients with multiple extranodal lesions. JAM-A maintained B-lymphoma cell stemness and associated with cell invasion and epithelial-to-mesenchymal transition. Its overexpression selectively activated TGF-beta/NODAL signaling, thereby enhanced cell aggressiveness and induced extranodal involvement to mesoendoderm-derived organs in DLBCL. | JAM-A overexpression is related to disease progression in diffuse large B-cell lymphoma and downregulated by lenalidomide.
Xu PP, Sun YF, Fang Y, Song Q, Yan ZX, Chen Y, Jiang XF, Fei XC, Zhao Y, Leboeuf C, Li B, Wang CF, Janin A, Wang L, Zhao WL., Free PMC Article | 02/23/2019 |
| These results demonstrate that therapeutic targeting of JAM-A has the potential to prevent MM progression, and lead us to propose JAM-A as a biomarker in MM, and sJAM-A as a serum-based marker for clinical stratification. | JAM-A as a prognostic factor and new therapeutic target in multiple myeloma.
Solimando AG, Brandl A, Mattenheimer K, Graf C, Ritz M, Ruckdeschel A, Stühmer T, Mokhtari Z, Rudelius M, Dotterweich J, Bittrich M, Desantis V, Ebert R, Trerotoli P, Frassanito MA, Rosenwald A, Vacca A, Einsele H, Jakob F, Beilhack A., Free PMC Article | 02/9/2019 |
| The functional diversity of JAM-A resides to a large part in a C-terminal PDZ domain binding motif which directly interacts with nine different PDZ domain-containing proteins. (Review) | Junctional adhesion molecule-A: functional diversity through molecular promiscuity.
Steinbacher T, Kummer D, Ebnet K., Free PMC Article | 11/3/2018 |
| JAM-A was expressed in all gliomas included in this study. The JAM-A intensity increased with malignancy grade, while its prognostic value was limited. | Expression and prognostic value of JAM-A in gliomas.
Rosager AM, Sørensen MD, Dahlrot RH, Boldt HB, Hansen S, Lathia JD, Kristensen BW., Free PMC Article | 06/23/2018 |
| JAM-A protein plays protective role in pathogenesis of age related diseases as Atherosclerosis, Apoplexy, thrombosis, Hypertension, Ophthalmological pathology.Short peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly could influence on F11R gene expression leading to recovery of JAM-A synthesis in cells. | [Adhesion molecule JAM-A, its function and mechanism of epigenetic regulation].
Kuznik BI, Khavinson VK, Tarnovskaya SI, Linkova NS, Kozina LS, Dyakonov MM. | 02/10/2018 |
| Dysregulation of JAM-A via p63/GATA-3 signaling pathway occurs in squamous cell carcinomas of the head and neck. | Dysregulation of junctional adhesion molecule-A via p63/GATA-3 in head and neck squamous cell carcinoma.
Kakuki T, Kurose M, Takano K, Kondoh A, Obata K, Nomura K, Miyata R, Kaneko Y, Konno T, Takahashi S, Hatakeyama T, Kohno T, Himi T, Kojima T., Free PMC Article | 12/23/2017 |
| JAM family members differentially regulate CXCR4 function and CXCL12 secretion in the bone marrow niche. | Junctional Adhesion Molecule-A Is Highly Expressed on Human Hematopoietic Repopulating Cells and Associates with the Key Hematopoietic Chemokine Receptor CXCR4.
Chang CH, Hale SJ, Cox CV, Blair A, Kronsteiner B, Grabowska R, Zhang Y, Cook D, Khoo CP, Schrader JB, Kabuga SB, Martin-Rendon E, Watt SM. | 12/9/2017 |