| PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness. | PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness.
Streitfeld WS, Dalton AC, Howley BV, Howe PH., Free PMC Article | 11/21/2023 |
| Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program. | Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program.
Park J, Shim JK, Lee M, Kim D, Yoon SJ, Moon JH, Kim EH, Park JY, Chang JH, Kang SG., Free PMC Article | 10/11/2023 |
| PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation. | PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation.
Luo Y, Zhang Y, Pang S, Min J, Wang T, Wu D, Lin C, Xiao Z, Xiang Q, Li Q, Ma L. | 06/18/2023 |
| Overexpression of splicing factor poly(rC)-binding protein 1 elicits cycle arrest, apoptosis induction, and p73 splicing in human cervical carcinoma cells. | Overexpression of splicing factor poly(rC)-binding protein 1 elicits cycle arrest, apoptosis induction, and p73 splicing in human cervical carcinoma cells.
Chen Y, Dou Z, Chen X, Zhao D, Che T, Su W, Qu T, Zhang T, Xu C, Lei H, Li Q, Zhang H, Di C. | 10/29/2022 |
| Poly(rC) Binding Protein 1 Represses the Translation of STAT3 through 5' UTR. | Poly(rC) Binding Protein 1 Represses the Translation of STAT3 through 5' UTR.
Li Z, Wang X, Jia R. | 10/15/2022 |
| PCBP1 is associated with rheumatoid arthritis by affecting RNA products of genes involved in immune response in Th1 cells. | PCBP1 is associated with rheumatoid arthritis by affecting RNA products of genes involved in immune response in Th1 cells.
Cao X, Li P, Song X, Shi L, Qin L, Chen D, Chu T, Cheng Y., Free PMC Article | 05/28/2022 |
| PolyC-RNA-binding protein 1 (PCBP1) enhances tropomyosin 3 (TPM3) mRNA stability to promote the progression of esophageal squamous cell carcinoma. | PolyC-RNA-binding protein 1 (PCBP1) enhances tropomyosin 3 (TPM3) mRNA stability to promote the progression of esophageal squamous cell carcinoma.
Peng K, Chen X, Lin A, Tong Z, Lin W., Free PMC Article | 05/7/2022 |
| Poly(rC)-binding protein 1 represses ferritinophagy-mediated ferroptosis in head and neck cancer. | Poly(rC)-binding protein 1 represses ferritinophagy-mediated ferroptosis in head and neck cancer.
Lee J, You JH, Roh JL., Free PMC Article | 04/23/2022 |
| RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity. | RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity.
Ansa-Addo EA, Huang HC, Riesenberg B, Iamsawat S, Borucki D, Nelson MH, Nam JH, Chung D, Paulos CM, Liu B, Yu XZ, Philpott C, Howe PH, Li Z., Free PMC Article | 04/16/2022 |
| Poly(rC)-Binding Protein 1 Limits Hepatitis C Virus Virion Assembly and Secretion. | Poly(rC)-Binding Protein 1 Limits Hepatitis C Virus Virion Assembly and Secretion.
Cousineau SE, Rheault M, Sagan SM., Free PMC Article | 03/12/2022 |
| Host Restriction Factor A3G Inhibits the Replication of Enterovirus D68 by Competitively Binding the 5' Untranslated Region with PCBP1. | Host Restriction Factor A3G Inhibits the Replication of Enterovirus D68 by Competitively Binding the 5' Untranslated Region with PCBP1.
Li Z, Yang X, Zhao Z, Liu X, Zhang W., Free PMC Article | 02/19/2022 |
| Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity. | Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity.
Mohanty BK, Karam JA, Howley BV, Dalton AC, Grelet S, Dincman T, Streitfeld WS, Yoon JH, Balakrishnan L, Chazin WJ, Long DT, Howe PH., Free PMC Article | 01/15/2022 |
| The iron chaperone and nucleic acid-binding activities of poly(rC)-binding protein 1 are separable and independently essential. | The iron chaperone and nucleic acid-binding activities of poly(rC)-binding protein 1 are separable and independently essential.
Patel SJ, Protchenko O, Shakoury-Elizeh M, Baratz E, Jadhav S, Philpott CC., Free PMC Article | 12/4/2021 |
| PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions. | PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions.
Ishii T, Igawa T, Hayakawa H, Fujita T, Sekiguchi M, Nakabeppu Y., Free PMC Article | 01/23/2021 |
| Management versus miscues in the cytosolic labile iron pool: The varied functions of iron chaperones. | Management versus miscues in the cytosolic labile iron pool: The varied functions of iron chaperones.
Philpott CC, Patel SJ, Protchenko O., Free PMC Article | 01/9/2021 |
| Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone. | Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone.
Bae DH, Lane DJR, Siafakas AR, Sutak R, Paluncic J, Huang MLH, Jansson PJ, Rahmanto YS, Richardson DR. | 12/5/2020 |
| PCBP1 is the key splicing factor that promotes the switch from oncogenic isoform STAT3alpha to tumor-suppressive isoform STAT3beta. | PCBP1 inhibits the expression of oncogenic STAT3 isoform by targeting alternative splicing of STAT3 exon 23.
Wang X, Guo J, Che X, Jia R., Free PMC Article | 04/11/2020 |
| PCBP1 has a function of inducing cell death to eliminate severely damaged RNA (REVIEW) | Two ways of escaping from oxidative RNA damage: Selective degradation and cell death.
Ishii T, Sekiguchi M. | 03/28/2020 |
| PCBP1 regulates post-transcriptional expression of TRIM56 in ovarian cancer. | Poly r(C) Binding Protein 1 Regulates Posttranscriptional Expression of the Ubiquitin Ligase TRIM56 in Ovarian Cancer.
Zhao L, Wang ZG, Zhang P, Yu XF, Su XJ. | 01/18/2020 |
| PCBP2 appears to be an oncogenic splicing factor. A growing body of evidence has shown that PCBP1 regulates alternative splicing, translation, and RNA stability of many cancer-related genes. Taking together, PCBP1 has distinctive tumor suppressive functions, and increasing PCBP1 expression may represent a new approach for cancer treatment. | Splicing factor poly(rC)-binding protein 1 is a novel and distinctive tumor suppressor.
Guo J, Jia R. | 10/5/2019 |
| PCBP1 and miR-3978 are sequestered in normal peritoneal tissue, but disrupted following metastatic progression. PCBP1 expression mimicked miR-3978 expression across gastric cancer patients. Replenishment of miR-3978 in the peritoneal metastasis cell line MKN45 resulted in induction of PCBP1 protein expression, potentially indicating that miR-3978 expression might downregulate a negative regulator targeting PCBP1. | Expression of both poly r(C) binding protein 1 (PCBP1) and miRNA-3978 is suppressed in peritoneal gastric cancer metastasis.
Ji FJ, Wu YY, An Z, Liu XS, Jiang JN, Chen FF, Fang XD., Free PMC Article | 07/27/2019 |
| Results thereby indicate that loss of PCBP1 expression firstly attenuates p27 expression at post-transcriptional level, and subsequently promotes carcinogenesis. | PCBP1 depletion promotes tumorigenesis through attenuation of p27(Kip1) mRNA stability and translation.
Shi H, Li H, Yuan R, Guan W, Zhang X, Zhang S, Zhang W, Tong F, Li L, Song Z, Wang C, Yang S, Wang H., Free PMC Article | 03/30/2019 |
| the actions of PCBP1 and NCOA4 on ferritin allow erythroid cells to rapidly respond to changes in cellular iron availability, which could provide a strategy to maintain cellular iron storage and utilization at a constant rate despite fluctuation in the total cellular iron supply. | Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells.
Ryu MS, Duck KA, Philpott CC., Free PMC Article | 03/16/2019 |
| Knockdown of PCBP1 promoted both tumorigenesis and metastatic progression in prostate cancer, suggestive of PCBP1 functioning as a tumor suppressor in normal prostate epithelial cells and potentiates tumor formation by up-regulation of MAPK1 expression. | The RNA-Binding Protein PCBP1 Functions as a Tumor Suppressor in Prostate Cancer by Inhibiting Mitogen Activated Protein Kinase 1.
Zhang Y, Meng L, Xiao L, Liu R, Li Z, Wang YL. | 09/15/2018 |
| PCBP1 binds to more severely oxidized RNA to activate apoptosis-related reactions. PCBP1 does not bind to such oligoribonucleotides but instead binds firmly to oligoribonucleotides in which two 8-oxoG residues are located nearby. The structure-function relationship of PCBP1 was established with the use of PCBP1 mutant proteins with defective conserved KH domains. PCBP1 operates when RNA is more severely damaged. | Specific binding of PCBP1 to heavily oxidized RNA to induce cell death.
Ishii T, Hayakawa H, Igawa T, Sekiguchi T, Sekiguchi M., Free PMC Article | 09/8/2018 |