| Dysregulation of phosphoenolpyruvate carboxykinase in cancers: A comprehensive analysis. | Dysregulation of phosphoenolpyruvate carboxykinase in cancers: A comprehensive analysis.
Xue S, Cai Y, Liu J, Ji K, Yi P, Long H, Zhang X, Li P, Song Y. | 06/21/2024 |
| Upregulation of p300 in paclitaxel-resistant TNBC: implications for cell proliferation via the PCK1/AMPK axis. | Upregulation of p300 in paclitaxel-resistant TNBC: implications for cell proliferation via the PCK1/AMPK axis.
Zhao PW, Cui JX, Wang XM. | 02/23/2024 |
| Expanding the clinical spectrum of cytosolic phosphoenolpyruvate carboxykinase deficiency: novel PCK1 variants in four Arabian Gulf families. | Expanding the clinical spectrum of cytosolic phosphoenolpyruvate carboxykinase deficiency: novel PCK1 variants in four Arabian Gulf families.
Al Busaidi M, Mohamed FE, Al-Ajmi E, Al Hashmi N, Al-Thihli K, Al Futaisi A, Al Mamari W, Al-Murshedi F, Al-Jasmi F., Free PMC Article | 11/21/2023 |
| Suppression of SLC39A6-CREB1 axis in liver cancer causes PCK1-mediated mitochondrial dysfunction. | Suppression of SLC39A6-CREB1 axis in liver cancer causes PCK1-mediated mitochondrial dysfunction.
Yu Z, Chen C, Gu H, Dong J, Zhang Y, Wang J, Ma H, Zhang G., Free PMC Article | 10/4/2023 |
| Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression. | Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression.
Gou D, Liu R, Shan X, Deng H, Chen C, Xiang J, Liu Y, Gao Q, Li Z, Huang A, Wang K, Tang N., Free PMC Article | 07/7/2023 |
| MiR-93-5P Represses the Gluconeogenesis of Hepatocellular Carcinoma while Boosting Its Glycolysis and Malignant Progression by Suppressing PCK1. | MiR-93-5P Represses the Gluconeogenesis of Hepatocellular Carcinoma while Boosting Its Glycolysis and Malignant Progression by Suppressing PCK1.
Zhou X, Huang L, Xing R, Yang F, Nie H. | 04/9/2022 |
| Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis. | Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis.
Yu S, Meng S, Xiang M, Ma H., Free PMC Article | 03/26/2022 |
| PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer. | PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer.
Wen YC, Liu CL, Yeh HL, Chen WH, Jiang KC, Tram VTN, Hsiao M, Huang J, Chen WY, Liu YN., Free PMC Article | 03/12/2022 |
| Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation. | Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation.
Xiang J, Chen C, Liu R, Gou D, Chang L, Deng H, Gao Q, Zhang W, Tuo L, Pan X, Liang L, Xia J, Huang L, Yao K, Wang B, Hu Z, Huang A, Wang K, Tang N., Free PMC Article | 10/2/2021 |
| Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity. | Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity.
Latorre-Muro P, Baeza J, Hurtado-Guerrero R, Hicks T, Delso I, Hernández-Ruiz C, Velázquez-Campoy A, Lawton AJ, Angulo J, Denu JM, Carrodeguas JA., Free PMC Article | 09/4/2021 |
| Novel missense variants in PCK1 gene cause cytosolic PEPCK deficiency with growth failure from inadequate caloric intake. | Novel missense variants in PCK1 gene cause cytosolic PEPCK deficiency with growth failure from inadequate caloric intake.
Oishi K, Siegel C, Cork EE, Chen H, Imagawa E. | 07/17/2021 |
| Association of phosphoenolpyruvate carboxykinase 1 protein kinase activity-dependent sterol regulatory element-binding protein 1 activation with prognosis of oesophageal carcinoma. | Association of phosphoenolpyruvate carboxykinase 1 protein kinase activity-dependent sterol regulatory element-binding protein 1 activation with prognosis of oesophageal carcinoma.
Shao F, Bian X, Jiang H, Zhao G, Zhu L, Xu D, Wang S, Guo W, Xing D, Xue Q, Gao Y, He J, Lu Z. | 06/26/2021 |
| Recognition of the gluconeogenic enzyme, Pck1, via the Gid4 E3 ligase: An in silico perspective. | Recognition of the gluconeogenic enzyme, Pck1, via the Gid4 E3 ligase: An in silico perspective.
Ismail AM, Elfiky AA, Elshemey WM. | 05/29/2021 |
| Hepatocellular carcinoma cell-derived extracellular vesicles encapsulated microRNA-584-5p facilitates angiogenesis through PCK1-mediated nuclear factor E2-related factor 2 signaling pathway. | Hepatocellular carcinoma cell-derived extracellular vesicles encapsulated microRNA-584-5p facilitates angiogenesis through PCK1-mediated nuclear factor E2-related factor 2 signaling pathway.
Shao Z, Pan Q, Zhang Y. | 01/16/2021 |
| Hypoxia increases the rate of renal gluconeogenesis via hypoxia-inducible factor-1-dependent activation of phosphoenolpyruvate carboxykinase expression. | Hypoxia increases the rate of renal gluconeogenesis via hypoxia-inducible factor-1-dependent activation of phosphoenolpyruvate carboxykinase expression.
Owczarek A, Gieczewska K, Jarzyna R, Jagielski AK, Kiersztan A, Gruza A, Winiarska K. | 12/19/2020 |
| Cytosolic phosphoenolpyruvate carboxykinase is expressed in alpha-cells from human and murine pancreas. | Cytosolic phosphoenolpyruvate carboxykinase is expressed in α-cells from human and murine pancreas.
Westermeier F, Holyoak T, Gatica R, Martínez F, Negrón M, Yáñez AJ, Nahmias D, Nualart F, Burbulis I, Bertinat R. | 08/22/2020 |
| the gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis; findings highlight the importance of the protein kinase activity of PCK1 in the activation of SREBPs, lipogenesis and the development of hepatocellular carcinoma | The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, Hung MC, Lu Z. | 06/6/2020 |
| These findings implicate DHODH and PCK1 in the colorectal cancer metastatic progression via pyrimidine nucleotide biosynthesis under hypoxia. | PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis.
Yamaguchi N, Weinberg EM, Nguyen A, Liberti MV, Goodarzi H, Janjigian YY, Paty PB, Saltz LB, Kingham TP, Loo JM, de Stanchina E, Tavazoie SF., Free PMC Article | 05/30/2020 |
| Results find that PCK1 level was upregulated in biliary atresia patients who had successful Kasai portoenterostomy (KPE), while there was a significant down regulation in patients who failed KPE. These data suggest that down regulation of PCK1 is a biological marker for good prognosis of patients with biliary atresia. | RNA-seq reveals outcome-specific gene expression of MMP7 and PCK1 in biliary atresia.
Ramachandran P, Balamurali D, Peter JJ, Kumar MM, Safwan M, Vij M, Rela M, Mahalingam S. | 02/22/2020 |
| These data suggested that PCK1 induced by Hepatitis B virus X protein led to decreased Hepatitis B virus replication through the downregulation of PGC-1alpha and PPAR-gamma. | Increased expression of phosphoenolpyruvate carboxykinase cytoplasmic isoform by hepatitis B virus X protein affects hepatitis B virus replication.
Tang X, Yan L, Li H, Du L, Shi Y, Huang F, Tang H. | 01/18/2020 |
| SLC2A4, RBP4, PCK1, and PIK3R1 genes may be involved in the pathogenesis of GDM. | Relationships of SLC2A4, RBP4, PCK1, and PI3K Gene Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population.
Hu S, Ma S, Li X, Tian Z, Liang H, Yan J, Chen M, Tan H., Free PMC Article | 06/15/2019 |
| This study revealed that PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27(Kip1) axis and supports a potential therapeutic and protective effect of metformin on hepatocellular carcinoma. | PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27(Kip1) axis.
Tuo L, Xiang J, Pan X, Hu J, Tang H, Liang L, Xia J, Hu Y, Zhang W, Huang A, Wang K, Tang N., Free PMC Article | 06/8/2019 |
| PCK1 is detrimental to malignant hepatocytes and activating PCK1 expression is a potential treatment strategy for patients with hepatocellular carcinoma. | Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma.
Liu MX, Jin L, Sun SJ, Liu P, Feng X, Cheng ZL, Liu WR, Guan KL, Shi YH, Yuan HX, Xiong Y., Free PMC Article | 03/30/2019 |
| This study reveals a unique mechanism to suppress hepatocellular carcinoma by switching from glycolysis to gluconeogenesis through Nur77 antagonism of PEPCK1 degradation. | Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation.
Bian XL, Chen HZ, Yang PB, Li YP, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q., Free PMC Article | 11/10/2018 |
| circC3P1 acts as a tumor suppressor via enhancing PCK1 expression by sponging miR-4641 in hepatocellular carcinoma. | Circular RNA circC3P1 suppresses hepatocellular carcinoma growth and metastasis through miR-4641/PCK1 pathway.
Zhong L, Wang Y, Cheng Y, Wang W, Lu B, Zhu L, Ma Y. | 10/13/2018 |