| MEMO1 binds iron and modulates iron homeostasis in cancer cells. | MEMO1 binds iron and modulates iron homeostasis in cancer cells.
Dolgova N, Uhlemann EE, Boniecki MT, Vizeacoumar FS, Ara A, Nouri P, Ralle M, Tonelli M, Abbas SA, Patry J, Elhasasna H, Freywald A, Vizeacoumar FJ, Dmitriev OY., Free PMC Article | 06/7/2024 |
| WD repeat protein 54-mediator of ErbB2-driven cell motility 1 axis promotes bladder cancer tumorigenesis and metastasis and impairs chemosensitivity. | WD repeat protein 54-mediator of ErbB2-driven cell motility 1 axis promotes bladder cancer tumorigenesis and metastasis and impairs chemosensitivity.
Wei X, Wang B, Wu Z, Yang X, Guo Y, Yang Y, Fang Z, Yi C, Zhang L, Fan X, Zhang L, Song D. | 02/22/2023 |
| Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro. | Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro.
Zhang X, Walke GR, Horvath I, Kumar R, Blockhuys S, Holgersson S, Walton PH, Wittung-Stafshede P., Free PMC Article | 09/10/2022 |
| miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1. | miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1.
Xu K, Shi J, Mo D, Yang Y, Fu Q, Luo Y., Free PMC Article | 10/16/2021 |
| Finding MEMO-Emerging Evidence for MEMO1's Function in Development and Disease. | Finding MEMO-Emerging Evidence for MEMO1's Function in Development and Disease.
Schotanus MD, Van Otterloo E., Free PMC Article | 07/31/2021 |
| Memo1 is a mediator of radial glial cell scaffold tiling, necessary to generate and organize neurons into functional ensembles in the developing cerebral cortex. | Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development.
Nakagawa N, Plestant C, Yabuno-Nakagawa K, Li J, Lee J, Huang CW, Lee A, Krupa O, Adhikari A, Thompson S, Rhynes T, Arevalo V, Stein JL, Molnár Z, Badache A, Anton ES., Free PMC Article | 03/28/2020 |
| Study identify Memo as an important key mediator between the heregulin and estrogen signaling pathways, which affects both breast cancer cell migration and proliferation. | Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization.
Frei A, MacDonald G, Lund I, Gustafsson JÅ, Hynes NE, Nalvarte I., Free PMC Article | 01/20/2018 |
| HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer | HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer.
Bogoevska V, Wolters-Eisfeld G, Hofmann BT, El Gammal AT, Mercanoglu B, Gebauer F, Vashist YK, Bogoevski D, Perez D, Gagliani N, Izbicki JR, Bockhorn M, Güngör C. | 09/2/2017 |
| Observational study of gene-disease association. (HuGE Navigator) | Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.
Dick DM, Meyers J, Aliev F, Nurnberger J Jr, Kramer J, Kuperman S, Porjesz B, Tischfield J, Edenberg HJ, Foroud T, Schuckit M, Goate A, Hesselbrock V, Bierut L., Free PMC Article | 08/24/2017 |
| Biochemical assays revealed that Memo is a copper-dependent redox enzyme that promoted a more oxidized intracellular milieu and stimulated the production of reactive oxygen species (ROS) in cellular structures involved in migration. | Memo is a copper-dependent redox protein with an essential role in migration and metastasis.
MacDonald G, Nalvarte I, Smirnova T, Vecchi M, Aceto N, Dolemeyer A, Frei A, Lienhard S, Wyckoff J, Hess D, Seebacher J, Keusch JJ, Gut H, Salaun D, Mazzarol G, Disalvatore D, Bentires-Alj M, Di Fiore PP, Badache A, Hynes NE. | 02/14/2015 |
| Mediator of ERBB2-driven cell motility (MEMO) promotes extranuclear estrogen receptor signaling involving the growth factor receptors IGF1R and ERBB2. | Mediator of ERBB2-driven cell motility (MEMO) promotes extranuclear estrogen receptor signaling involving the growth factor receptors IGF1R and ERBB2.
Jiang K, Yang Z, Cheng L, Wang S, Ning K, Zhou L, Lin J, Zhong H, Wang L, Li Y, Huang J, Zhang H, Ye Q., Free PMC Article | 11/16/2013 |
| MEMO1 is involved in breast carcinogenesis via regulating insulin-like growth factor-I receptor-dependent signaling events. | MEMO1, a new IRS1-interacting protein, induces epithelial-mesenchymal transition in mammary epithelial cells.
Sorokin AV, Chen J. | 09/7/2013 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Memo was detected in complexes with cofilin, ErbB2 and PLCgamma1. | Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration.
Meira M, Masson R, Stagljar I, Lienhard S, Maurer F, Boulay A, Hynes NE. | 01/21/2010 |
| Memo-RhoA-mDia1 signaling coordinates the organization of the lamellipodial actin network, adhesion site formation, and microtubule outgrowth within the cell leading edge to sustain cell motility. | Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells.
Zaoui K, Honoré S, Isnardon D, Braguer D, Badache A., Free PMC Article | 01/21/2010 |
| 2.1A crystal structure and homology to class III nonheme iron-dependent dioxygenases | Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site.
Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ. | 01/21/2010 |
| data suggest that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton [Memo] | Memo mediates ErbB2-driven cell motility.
Marone R, Hess D, Dankort D, Muller WJ, Hynes NE, Badache A. | 01/21/2010 |