| Role of hematological and neurological expressed 1 (HN1) in human cancers. | Role of hematological and neurological expressed 1 (HN1) in human cancers.
Li H, Fan S, Gong Z, Chan JYK, Tong MCF, Chen GG. | 08/22/2024 |
| Hematological and neurological expressed 1 (HN1) activates c-Myc signaling by inhibiting ubiquitin-mediated proteasomal degradation of c-Myc in hepatocellular carcinoma. | Hematological and neurological expressed 1 (HN1) activates c-Myc signaling by inhibiting ubiquitin-mediated proteasomal degradation of c-Myc in hepatocellular carcinoma.
Feng J, Liu Y, Fang T, Zhu J, Wang G, Li J. | 02/28/2023 |
| Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1. | Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1.
Peng J, Shuopeng J, Wang H, Wang X, Wang L., Free PMC Article | 02/13/2023 |
| LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer. | LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer.
Cheng Y, Xiong HY, Li YM, Zuo HR, Liu Y, Liao GL. | 03/5/2022 |
| Jupiter microtubule-associated homolog 1 (JPT1): A predictive and pharmacodynamic biomarker of metformin response in endometrial cancers. | Jupiter microtubule-associated homolog 1 (JPT1): A predictive and pharmacodynamic biomarker of metformin response in endometrial cancers.
Bateman NW, Teng PN, Hope E, Hood BL, Oliver J, Ao W, Zhou M, Wang G, Tommarello D, Wilson K, Litzy T, Conrads KA, Hamilton CA, Darcy KM, Casablanca Y, Maxwell GL, Bae-Jump V, Conrads TP., Free PMC Article | 05/1/2021 |
| HN1 as a diagnostic and prognostic biomarker for liver cancer. | HN1 as a diagnostic and prognostic biomarker for liver cancer.
Liu Z, Yang D, Li Y, Jiao Y, Lv G., Free PMC Article | 04/17/2021 |
| HN1 promotes tumor associated lymphangiogenesis and lymph node metastasis via NF-kappaB signaling activation in cervical carcinoma. | HN1 promotes tumor associated lymphangiogenesis and lymph node metastasis via NF-κB signaling activation in cervical carcinoma.
Chen J, Qiu J, Li F, Jiang X, Sun X, Zheng L, Zhang W, Li H, Wu H, Ouyang Y, Chen X, Lin C, Song L, Zhang Y. | 02/27/2021 |
| HNRNPA1-mediated alternative polyadenylation of HN1 contributes to cancer- and senescence-related phenotypes. | HNRNPA1-mediated 3' UTR length changes of HN1 contributes to cancer- and senescence-associated phenotypes.
Jia Q, Nie H, Yu P, Xie B, Wang C, Yang F, Wei G, Ni T., Free PMC Article | 07/25/2020 |
| Downregulation of MYC abrogated the effect of HN1 overexpression in breast cancer cell lines. Taken together, these data reveal that HN1 promotes the progression of breast cancer by upregulating MYC expression, and might be a therapeutic target for breast cancer. | HN1 contributes to migration, invasion, and tumorigenesis of breast cancer by enhancing MYC activity.
Zhang C, Xu B, Lu S, Zhao Y, Liu P., Free PMC Article | 02/24/2018 |
| Data report that HN1 is an essential factor for beta-catenin turnover and signaling, augments cell growth and migration in prostate cancer cells. | HN1 negatively influences the β-catenin/E-cadherin interaction, and contributes to migration in prostate cells.
Varisli L, Ozturk BE, Akyuz GK, Korkmaz KS. | 01/30/2016 |
| miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3' UTR of HN1. | MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1.
Zhang ZG, Chen WX, Wu YH, Liang HF, Zhang BX. | 05/2/2015 |
| HN1 maintains a balance between the androgen-regulated nuclear translocation of androgen receptor and steady-state Akt phosphorylation, predominantly in the absence of androgens. | Androgen regulated HN1 leads proteosomal degradation of androgen receptor (AR) and negatively influences AR mediated transactivation in prostate cells.
Varisli L, Gonen-Korkmaz C, Syed HM, Bogurcu N, Debelec-Butuner B, Erbaykent-Tepedelen B, Korkmaz KS. | 05/19/2012 |
| EGF and kinase inhibitors increase HN1 expression, and Silencing of HN1 results in cell cycle alterations in prostate cells. | Ubiquitously expressed hematological and neurological expressed 1 downregulates Akt-mediated GSK3β signaling, and its knockdown results in deregulated G2/M transition in prostate cells.
Varisli L, Gonen-Korkmaz C, Debelec-Butuner B, Erbaykent-Tepedelen B, Muhammed HS, Bogurcu N, Saatcioglu F, Korkmaz KS. | 08/6/2011 |
| These data suggest a role for Hn1 in the biology of malignant brain tumors. | Hematopoietic- and neurologic-expressed sequence 1 expression in the murine GL261 and high-grade human gliomas.
Laughlin KM, Luo D, Liu C, Shaw G, Warrington KH Jr, Qiu J, Yachnis AT, Harrison JK., Free PMC Article | 03/8/2010 |