| DCXR promotes cell proliferation by promoting the activity of aerobic glycolysis in breast cancer. | DCXR promotes cell proliferation by promoting the activity of aerobic glycolysis in breast cancer.
Jin Y, Zhang M, Tong Y, Qiu L, Ye Y, Zhao B., Free PMC Article | 01/14/2023 |
| Ureaplasma urealyticum infection may affect the level of P34H protein expression on spermatozoa | The effect of Ureaplasma urealyticum on the level of P34H expression, the activity of hyaluronidase, and DNA fragmentation in human spermatozoa.
Ma XP, Gao XQ. | 12/30/2017 |
| identification of DCXR as an enzyme activity mediating chemical redox cycling suggests that it may be important in generating cytotoxic reactive oxygen species in the lung | Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells.
Yang S, Jan YH, Mishin V, Heck DE, Laskin DL, Laskin JD., Free PMC Article | 10/7/2017 |
| Low expression of DCXR is associated with hepatocellular carcinoma. | Low expression of DCXR protein indicates a poor prognosis for hepatocellular carcinoma patients.
Hang X, Wu Z, Chu K, Yu G, Peng H, Xin H, Miao X, Wang J, Xu W. | 03/4/2017 |
| EGCG is a potential inhibitor to human DCXR. | (-)-Epigallocatechin-3-gallate, a potential inhibitor to human dicarbonyl/L-xylulose reductase.
Hu XH, Ding LY, Huang WX, Yang XM, Xie F, Xu M, Yu L. | 11/2/2013 |
| combined frequency of the two mutant DCXR alleles in 1,067 Ashkenazi Jewish controls was 0.0173, suggesting a pentosuria frequency of approximately one in 3,300 in this population | Garrod's fourth inborn error of metabolism solved by the identification of mutations causing pentosuria.
Pierce SB, Spurrell CH, Mandell JB, Lee MK, Zeligson S, Bereman MS, Stray SM, Fokstuen S, MacCoss MJ, Levy-Lahad E, King MC, Motulsky AG., Free PMC Article | 01/28/2012 |
| The action of human XR may be regulated by cellular redox conditions through reversible disulfide-bond formation and by S-cysteinylation. | Structure/function analysis of a critical disulfide bond in the active site of L-xylulose reductase.
Zhao HT, Endo S, Ishikura S, Chung R, Hogg PJ, Hara A, El-Kabbani O., Free PMC Article | 01/21/2010 |
| DCXR trranfected into mice may function in the removal of renal alpha-dicarbonyl compounds under oxidative circumstances, but it is not sufficient to suppress acute renal fibrosis. | Suppression of renal alpha-dicarbonyl compounds generated following ureteral obstruction by kidney-specific alpha-dicarbonyl/L-xylulose reductase.
Odani H, Asami J, Ishii A, Oide K, Sudo T, Nakamura A, Miyata N, Otsuka N, Maeda K, Nakagawa J. | 01/21/2010 |
| DCXR overexpression has the potential to be an additional useful biomarker for prostate cancer. | Dicarbonyl/L-xylulose reductase: a potential biomarker identified by laser-capture microdissection-micro serial analysis of gene expression of human prostate adenocarcinoma.
Cho-Vega JH, Tsavachidis S, Do KA, Nakagawa J, Medeiros LJ, McDonnell TJ. | 01/21/2010 |
| A significant proportion of men investigated for male infertility may be epididymal protein P34H deficient. | Epididymal P34H protein deficiency in men evaluated for infertility.
Moskovtsev SI, Jarvi K, Légaré C, Sullivan R, Mullen JB. | 01/21/2010 |
| These results suggested that altered HCR2 expression might play roles in the carcinogenesis and progression of hepatocellular carcinoma. | Decreased expression of the human carbonyl reductase 2 gene HCR2 in hepatocellular carcinoma.
Liu S, Ma L, Huang W, Shai Y, Ji X, Ding L, Liu Y, Yu L, Zhao S., Free PMC Article | 01/21/2010 |
| crystallization and preliminary crystallographic analysis | Crystallization and preliminary crystallographic analysis of human L-xylulose reductase.
El-Kabbani O, Chung RP, Ishikura S, Usami N, Nakagawa J, Hara A. | 01/21/2010 |
| Decreased membranous expression of DCXR with altered subcellular localization appears to be associated with malignant progression of melanocytic lesions in human skin. | Expression of dicarbonyl/L-xylulose reductase (DCXR) in human skin and melanocytic lesions: morphological studies supporting cell adhesion function of DCXR.
Cho-Vega JH, Vega F, Schwartz MR, Prieto VG. | 01/21/2010 |
| structure of the tetrameric form of human L-Xylulose reductase | Structure of the tetrameric form of human L-Xylulose reductase: probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis.
El-Kabbani O, Carbone V, Darmanin C, Ishikura S, Hara A. | 01/21/2010 |
| highly expressed in kidney and liver | Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney.
Nakagawa J, Ishikura S, Asami J, Isaji T, Usami N, Hara A, Sakurai T, Tsuritani K, Oda K, Takahashi M, Yoshimoto M, Otsuka N, Kitamura K. | 01/21/2010 |
| Our results demonstrate that the proportion of positive P34H cases that produced embryos in vitro clearly differs from cases with undetectable levels of P34H (P<.001). | Levels of P34H, a sperm protein of epididymal origin, as a predictor of conventional in vitro fertilization outcome.
Sullivan R, Légaré C, Villeneuve M, Foliguet B, Bissonnette F. | 01/21/2010 |