| Endothelial CLEC-1b plays a protective role against cancer hematogenous metastasis. | Endothelial CLEC-1b plays a protective role against cancer hematogenous metastasis.
Yamazaki E, Ikeda K, Urata R, Ueno D, Katayama A, Ito F, Ikegaya H, Matoba S. | 04/12/2024 |
| Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2. | Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2.
Bourne JH, Colicchia M, Di Y, Martin E, Slater A, Roumenina LT, Dimitrov JD, Watson SP, Rayes J., Free PMC Article | 07/10/2021 |
| Control of Platelet CLEC-2-Mediated Activation by Receptor Clustering and Tyrosine Kinase Signaling. | Control of Platelet CLEC-2-Mediated Activation by Receptor Clustering and Tyrosine Kinase Signaling.
Martyanov AA, Balabin FA, Dunster JL, Panteleev MA, Gibbins JM, Sveshnikova AN., Free PMC Article | 06/12/2021 |
| [Expression of Clec2 in Patients with Myelodysplastic Syndrome and Its Correlation with TPO]. | [Expression of Clec2 in Patients with Myelodysplastic Syndrome and Its Correlation with TPO].
Jin JC, Hao YW. | 10/24/2020 |
| Platelet membrane lipid rafts protein composition varies following GPVI and CLEC-2 receptors activation. | Platelet membrane lipid rafts protein composition varies following GPVI and CLEC-2 receptors activation.
Izquierdo I, Barrachina MN, Hermida-Nogueira L, Casas V, Eble JA, Carrascal M, Abián J, García Á. | 05/30/2020 |
| Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin. | Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin.
Suzuki-Inoue K. | 03/21/2020 |
| Functional significance of the platelet immune receptors GPVI and CLEC-2. | Functional significance of the platelet immune receptors GPVI and CLEC-2.
Rayes J, Watson SP, Nieswandt B., Free PMC Article | 11/9/2019 |
| tetraspanin CD37 controls CLEC-2 membrane organization and provides new molecular insights into the mechanisms underlying CLEC-2-dependent dendritic cell migration. | C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37.
de Winde CM, Matthews AL, van Deventer S, van der Schaaf A, Tomlinson ND, Jansen E, Eble JA, Nieswandt B, McGettrick HM, Figdor CG, Tomlinson MG, Acton SE, van Spriel AB. | 10/19/2019 |
| CLEC-2 may have a role in unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma | High CLEC-2 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma.
Xiong Y, Liu L, Xia Y, Wang J, Xi W, Bai Q, Qu Y, Long Q, Xu J, Guo J., Free PMC Article | 04/7/2018 |
| CLEC-2 and P2Y12 are required for CpG ODN-induced platelet activation and thrombosis, and might be targeted to prevent adverse events in patients at risk. | Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides.
Delierneux C, Donis N, Servais L, Wéra O, Lecut C, Vandereyken M, Musumeci L, Rahmouni S, Schneider J, Eble JA, Lancellotti P, Oury C. | 03/31/2018 |
| the CHIP/CLEC-2 axis may play an important role in the modulation of immune response. | E3 ubiquitin ligase CHIP interacts with C-type lectin-like receptor CLEC-2 and promotes its ubiquitin-proteasome degradation.
Shao M, Li L, Song S, Wu W, Peng P, Yang C, Zhang M, Duan F, Jia D, Zhang J, Wu H, Zhao R, Wang L, Ruan Y, Gu J. | 12/2/2017 |
| Data (including data from studies using cells from knockout mice) suggest that CLEC2/CLEC2R signaling is dependent on thromboxane A2 generation and is potentiated by co-stimulation with different GNAQ agonists. (CLEC2 = C-type lectin CLEC2; CLEC2R = CLEC2 receptor; GNAQ = guanine nucleotide-binding protein G[q] subunit alpha) | G(q) pathway regulates proximal C-type lectin-like receptor-2 (CLEC-2) signaling in platelets.
Badolia R, Inamdar V, Manne BK, Dangelmaier C, Eble JA, Kunapuli SP., Free PMC Article | 09/30/2017 |
| NZ-1 inhibits the hPDPN-CLEC-2 interaction and is also useful for anti-PA tag MAb.The minimum epitope of LpMab-13 was identified as Ala42-Asp49 of hPDPN using Western blot and flow cytometry. The combination of different epitope-possessing MAbs could be advantageous for the hPDPN-targeting diagnosis and therapy | Establishment of Mouse Monoclonal Antibody LpMab-13 Against Human Podoplanin.
Ogasawara S, Kaneko MK, Honma R, Oki H, Fujii Y, Takagi M, Suzuki H, Kato Y. | 04/22/2017 |
| CLEC2 prevents expression of PI3K subunits, in a SYK-dependent manner, to suppress the invasive activities of gastric cancer cells. | C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits.
Wang L, Yin J, Wang X, Shao M, Duan F, Wu W, Peng P, Jin J, Tang Y, Ruan Y, Sun Y, Gu J. | 04/8/2017 |
| CLEC-2 regulates Akt and MAPK downstream of PI3K and PKC, leading to phosphorylation and inhibition of GSK3alpha/beta, and enhanced platelet aggregation and secretion. | Akt and mitogen-activated protein kinase enhance C-type lectin-like receptor 2-mediated platelet activation by inhibition of glycogen synthase kinase 3α/β.
Moroi AJ, Watson SP., Free PMC Article | 02/27/2016 |
| Data (including data from studies using recombinant proteins) suggest that a diverse range of ligands activate platelets through activation/phosphorylation of CD36/GPVI (glycoprotein VI) and/or CLEC-2 (C-type lectin-like receptor-2). | Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands.
Alshehri OM, Montague S, Watson S, Carter P, Sarker N, Manne BK, Miller JL, Herr AB, Pollitt AY, O'Callaghan CA, Kunapuli S, Arman M, Hughes CE, Watson SP. | 10/10/2015 |
| PI3K and Tec family kinases play a crucial role in the regulation of platelet activation and Syk phosphorylation downstream of the CLEC-2 receptor | Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets.
Manne BK, Badolia R, Dangelmaier C, Eble JA, Ellmeier W, Kahn M, Kunapuli SP., Free PMC Article | 07/25/2015 |
| fucoidan is a novel CLEC-2 receptor agonist that activates platelets through a SFK-dependent signaling pathway | Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2).
Manne BK, Getz TM, Hughes CE, Alshehri O, Dangelmaier C, Naik UP, Watson SP, Kunapuli SP., Free PMC Article | 05/18/2013 |
| Dimerization of two phosphorylated CLEC-2 molecules leads to recruitment of the tyrosine kinase Syk via its tandem SH2 domains and initiation of a downstream signaling cascade | Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).
Hughes CE, Sinha U, Pandey A, Eble JA, O'Callaghan CA, Watson SP., Free PMC Article | 05/4/2013 |
| A differential proteomic analysis of basal and rhodocytin-activated platelets with the aim of providing novel clues on CLEC-2 signaling regulation. | A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation.
Parguiña AF, Alonso J, Rosa I, Vélez P, González-López MJ, Guitián E, Eble JA, Loza MI, García Á. | 02/16/2013 |
| The glycosylation sites (N120 and N134) are necessary for the surface expression of CLEC-2. | Structural and functional conservation of CLEC-2 with the species-specific regulation of transcript expression in evolution.
Wang L, Ren S, Zhu H, Zhang D, Hao Y, Ruan Y, Zhou L, Lee C, Qiu L, Yun X, Xie J. | 01/5/2013 |
| Shedding of CLEC-2 from the cell surface may reflect increased expression of this membrane protein and serve as a marker of disease activity. | The production of soluble C-type lectin-like receptor 2 is a regulated process.
Fei M, Zhou L, Xie J, Ruan Y, Xu J, He S, Shen H, Hu Y, Ren S, Ruan C. | 01/5/2013 |
| Here, the bidirectional relationship between CLEC-2 and podoplanin is described and considered in the context of tumour growth and metastasis. | Platelet CLEC-2 and podoplanin in cancer metastasis.
Lowe KL, Navarro-Nunez L, Watson SP. | 11/17/2012 |
| platelets regulate blood/lymphatic vessel separation by inhibiting the proliferation, migration, and tube formation of LECs, mainly because of the release of BMP-9 upon activation by CLEC-2/podoplanin in | Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells.
Osada M, Inoue O, Ding G, Shirai T, Ichise H, Hirayama K, Takano K, Yatomi Y, Hirashima M, Fujii H, Suzuki-Inoue K, Ozaki Y., Free PMC Article | 09/22/2012 |
| CLEC-2 is the first member of the C-type lectin family of receptors identified to stimulate platelet aggregation through a tyrosine kinase-dependent pathway. (Review) | The novel platelet activation receptor CLEC-2.
Suzuki-Inoue K, Inoue O, Ozaki Y. | 12/10/2011 |