| ECSIT facilitates memory CD8[+] T cell development by mediating fumarate synthesis during viral infection and tumorigenesis. | ECSIT facilitates memory CD8(+) T cell development by mediating fumarate synthesis during viral infection and tumorigenesis.
Yang Y, Wang Y, Wang Z, Yan H, Gong Y, Hu Y, Jiang Y, Wen S, Xu F, Wang B, Humphries F, Chen Y, Wang X, Yang S. | 03/19/2024 |
| ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein. | ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein.
Jiang Y, Ma C, Hu Y, Yang Y, Ma C, Wu C, Liu L, Wen S, Moynagh PN, Wang B, Yang S., Free PMC Article | 09/7/2023 |
| ECSIT is a critical limiting factor for cardiac function. | ECSIT is a critical limiting factor for cardiac function.
Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar KS, Hombrebueno JR, Stolz DB, Oleszycka E, Rodgers AM, Glezeva N, McDonald K, Watson CJ, Ledwidge MT, Ingram RJ, Grieve DJ, Moynagh PN., Free PMC Article | 01/29/2022 |
| No association between <i>ECSIT</i> germline mutations and hemophagocytic lymphohistiocytosis in natural killer/T-cell lymphoma. | No association between ECSIT germline mutations and hemophagocytic lymphohistiocytosis in natural killer/T-cell lymphoma.
Ong SY, Lim JQ, Grigoropoulos N, Laurensia Y, Huang D, Chia BKH, Zhe DCM, Saraf SA, Cheng CL, Chuang WY, Kuo MC, Su YJ, Phipps C, Nagarajan C, Lee YS, Lung DTC, Shih LY, Goh YT, Lim ST, Ong CK., Free PMC Article | 06/5/2021 |
| CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1. | CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1.
Kim MJ, Min Y, Shim JH, Chun E, Lee KY., Free PMC Article | 11/21/2020 |
| We added thalidomide to the conventional dexamethasone-containing therapy regimen for two patients with HPS who expressed ECSIT-V140A, and we observed reversal of their HPS and disease-free survival for longer than 3 years. These findings provide mechanistic insights and a potential therapeutic strategy for extranodal natural killer/T cell lymphoma-associated Hemophagocytic syndrome. | Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma.
Wen H, Ma H, Cai Q, Lin S, Lei X, He B, Wu S, Wang Z, Gao Y, Liu W, Liu W, Tao Q, Long Z, Yan M, Li D, Kelley KW, Yang Y, Huang H, Liu Q. | 05/11/2019 |
| mediates virus-triggered type I IFN induction by bridging RIG-I and MDA5 to the VISA complex | ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses.
Lei CQ, Zhang Y, Li M, Jiang LQ, Zhong B, Kim YH, Shu HB., Free PMC Article | 12/26/2015 |
| Ubiquitination of ECSIT might have a role in the regulation of NF-kappaB activity in TLR4 signaling. | Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling.
Mi Wi S, Park J, Shim JH, Chun E, Lee KY., Free PMC Article | 08/22/2015 |
| Authors conclude that ECSIT appears to be a novel Hepatitis B virus X protein-interacting signal molecule and their interaction is mechanistically important in IL-1beta induction of NF-kappaB activation. | Hepatitis B virus X protein increases the IL-1β-induced NF-κB activation via interaction with evolutionarily conserved signaling intermediate in Toll pathways (ECSIT).
Chen WN, Liu LL, Jiao BY, Lin WS, Lin XJ, Lin X. | 07/25/2015 |
| Data show that the ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) complex, including MEKK7 (TAK1) and TNF receptor-associated factor 6 (TRAF6), plays a role in Toll-like receptor 4 -mediated signals to activate NF-kappa B. | TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB.
Wi SM, Moon G, Kim J, Kim ST, Shim JH, Chun E, Lee KY., Free PMC Article | 04/25/2015 |
| TRIM59 interacts with ECSIT as an adaptor protein required for the TLR-mediated transduction pathway. | TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways.
Kondo T, Watanabe M, Hatakeyama S. | 09/1/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| Study shows a mitochondrial function for Ecsit in the assembly of mitochondrial complex I, an N-terminal targeting signal directs Ecsit to mitochondria, where it interacts with assembly chaperone NDUFAF1. | Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly.
Vogel RO, Janssen RJ, van den Brand MA, Dieteren CE, Verkaart S, Koopman WJ, Willems PH, Pluk W, van den Heuvel LP, Smeitink JA, Nijtmans LG., Free PMC Article | 01/21/2010 |