| CC16 drives VLA-2-dependent SPLUNC1 expression. | CC16 drives VLA-2-dependent SPLUNC1 expression.
Iannuzo N, Welfley H, Li NC, Johnson MDL, Rojas-Quintero J, Polverino F, Guerra S, Li X, Cusanovich DA, Langlais PR, Ledford JG., Free PMC Article | 12/15/2023 |
| Lung SPLUNC1 Peptide Derivatives in the Lipid Membrane Headgroup Kill Gram-Negative Planktonic and Biofilm Bacteria. | Lung SPLUNC1 Peptide Derivatives in the Lipid Membrane Headgroup Kill Gram-Negative Planktonic and Biofilm Bacteria.
Jakkampudi T, Lin Q, Mitra S, Vijai A, Qin W, Kang A, Chen J, Ryan E, Wang R, Gong Y, Heinrich F, Song J, Di YP, Tristram-Nagle S., Free PMC Article | 06/13/2023 |
| [Correlation between the mRNA levels of BCRP and LUNX genes and pathological types and stages of patients with non-small cell lung cancer]. | [Correlation between the mRNA levels of BCRP and LUNX genes and pathological types and stages of patients with non-small cell lung cancer].
Chen D, Han W, Wang P, Ma H. | 02/4/2023 |
| BPIFA1 is a secreted biomarker of differentiating human airway epithelium. | BPIFA1 is a secreted biomarker of differentiating human airway epithelium.
Clifton C, Niemeyer BF, Novak R, Can UI, Hainline K, Benam KH., Free PMC Article | 12/24/2022 |
| SPLUNC1 regulates LPS-induced progression of nasopharyngeal carcinoma and proliferation of myeloid-derived suppressor cells. | SPLUNC1 regulates LPS-induced progression of nasopharyngeal carcinoma and proliferation of myeloid-derived suppressor cells.
Tang L, Peng L, Liu H, Xiao T, Gu W, Yang H, Wang H, Chen P. | 10/8/2022 |
| SPLUNC1 is a negative regulator of the Orai1 Ca(2+) channel. | SPLUNC1 is a negative regulator of the Orai1 Ca(2+) channel.
Wu T, Goriounova AS, Worthington EN, Wrennall JA, Ghosh A, Ahmad S, Flori Sassano M, Tarran R., Free PMC Article | 05/28/2022 |
| Relationship between circulating lung-specific X protein messenger ribonucleic acid expression and micrometastasis and prognosis in patients with early-stage nonsmall cell lung cancer. | Relationship between circulating lung-specific X protein messenger ribonucleic acid expression and micrometastasis and prognosis in patients with early-stage nonsmall cell lung cancer.
Cui Y, Wang W, Yao S, Qiu Z, Cong L. | 10/9/2021 |
| The SPLUNC1-betaENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia. | The SPLUNC1-βENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia.
Ahmad S, Kim CSK, Tarran R., Free PMC Article | 06/12/2021 |
| Degradation of bacterial permeability family member A1 (BPIFA1) by house dust mite (HDM) cysteine protease Der p 1 abrogates immune modulator function. | Degradation of bacterial permeability family member A1 (BPIFA1) by house dust mite (HDM) cysteine protease Der p 1 abrogates immune modulator function.
Zhang R, Trower J, Wu T., Free PMC Article | 04/17/2021 |
| A Rare Mutation in SPLUNC1 Affects Bacterial Adherence and Invasion in Meningococcal Disease. | A Rare Mutation in SPLUNC1 Affects Bacterial Adherence and Invasion in Meningococcal Disease.
Mashbat B, Bellos E, Hodeib S, Bidmos F, Thwaites RS, Lu Y, Wright VJ, Herberg JA, Klobassa DS, Zenz W, Hansel TT, Nadel S, Langford PR, Schlapbach LJ, Li MS, Redinbo MR, Di YP, Levin M, Sancho-Shimizu V., Free PMC Article | 03/27/2021 |
| Nasal epithelial cells from patients with mild to severe asthma with the BPIFA1 rs750064 CC genotype had significantly less BPIFA1 mRNA expression than the CT and TT genotypes. Data suggest that less BPIFA1 in asthma patients with the CC allele may predispose them to greater eosinophilic inflammation, which could be attenuated by rhBPIFA1 protein therapy. | The effect of BPIFA1/SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelium.
Schaefer N, Li X, Seibold MA, Jarjour NN, Denlinger LC, Castro M, Coverstone AM, Teague WG, Boomer J, Bleecker ER, Meyers DA, Moore WC, Hawkins GA, Fahy J, Phillips BR, Mauger DT, Dakhama A, Gellatly S, Pavelka N, Berman R, Di YP, Wenzel SE, Chu HW., Free PMC Article | 06/20/2020 |
| G allele of rs1078761 is associated with reduced lung function of cystic fibrosis patients. | Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1.
Saferali A, Tang AC, Strug LJ, Quon BS, Zlosnik J, Sandford AJ, Turvey SE., Free PMC Article | 04/11/2020 |
| Our results conclude that SPLUNC1 and MLL3 expression control the resistance mechanism of cancer stem cells in initial NPC, but their downregulation in aggressive stages contributes to developing resistance in nasopharyngeal cancer stem cells | SPLUNC1 and MLL3 regulate cancer stem cells in nasopharyngeal carcinoma.
Bian S, Wang Z, Chen Y, Li R. | 03/7/2020 |
| High LUNX expression is associated with Non-Small-Cell Lung Carcinoma. | Three Markers in Cancerous and Healthy Cells of Patients with Non-Small-Cell Lung Carcinoma (NSCLC).
Jamaati H, Khosravi A, Abedini A, Kiani A, Tabarsi P, Dargahi H, Bahrami N, Kazempour Dizaji M, Sadegh Beigee F, Pourabdollah M, Gheysouri A, Ahmadian N, Abniki M, Mohamadnia A, Velayati A., Free PMC Article | 01/25/2020 |
| The study found reduced endogenous SPLUNC1 in cystic fibrosis (CF) secretions, and rapid degradation of recombinant SPLUNC1 (rSPLUNC1) by CF secretions. Normal sputum, containing SPLUNC1 and SPLUNC1-derived peptides, inhibited epithelial Na(+) channel in both normal and CF human bronchial epithelial cells. | SPLUNC1 degradation by the cystic fibrosis mucosal environment drives airway surface liquid dehydration.
Webster MJ, Reidel B, Tan CD, Ghosh A, Alexis NE, Donaldson SH, Kesimer M, Ribeiro CMP, Tarran R., Free PMC Article | 08/24/2019 |
| data indicate that SPLUNC1 is an allosteric regulator of ENaC that dissociates alphabetagamma-ENaC to generate a new SPLUNC1-beta-ENaC complex. | SPLUNC1 is an allosteric modulator of the epithelial sodium channel.
Kim CS, Ahmad S, Wu T, Walton WG, Redinbo MR, Tarran R., Free PMC Article | 01/12/2019 |
| Study proposes that BPIFA1 (SPLUNC1) is the epithelium-derived smooth muscle relaxing factor and it functions by internalizing Orai1. BPIFA1 deficiency in asthmatic airways promotes Orai1 hyperactivity, increased airway smooth muscle contraction and airway hyperresponsiveness. | Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor.
Wu T, Huang J, Moore PJ, Little MS, Walton WG, Fellner RC, Alexis NE, Peter Di Y, Redinbo MR, Tilley SL, Tarran R., Free PMC Article | 11/10/2018 |
| BPIFA1 and BPIFB1 expressions are correlated with goblet cell metaplasia and inversely correlated with lung function parameters of airway obstruction (FEV1 and FEV1/FVC) in COPD patients. | Association of innate defense proteins BPIFA1 and BPIFB1 with disease severity in COPD.
De Smet EG, Seys LJ, Verhamme FM, Vanaudenaerde BM, Brusselle GG, Bingle CD, Bracke KR., Free PMC Article | 09/22/2018 |
| SPLUNC1 has antimicrobial and antibiofilm activities against the Burkholderia cepacia complex. | Short Palate, Lung, and Nasal Epithelial Clone 1 Has Antimicrobial and Antibiofilm Activities against the Burkholderia cepacia Complex.
Ahmad S, Tyrrell J, Walton WG, Tripathy A, Redinbo MR, Tarran R., Free PMC Article | 08/19/2017 |
| Data show that the palate, lung, and nasal epithelium clone (PLUNC) protein level was highly expressed in nontumor nasopharyngeal epithelium than that in nasopharyngeal carcinoma (NPC) tissues. | New insights on the palate, lung, and nasal epithelium clone (PLUNC) proteins: Based on molecular and functional analysis of its homolog of YH1/SPLUNC1.
Liu H, Zhang X, Wu J, French SW, He Z. | 06/24/2017 |
| These studies identify the role of SPLUNC1 in sinonasal innate immunity and the pathogenesis of CRS. Defective expression of SPLUNC1 in CRSwNP patients may lead to insufficient maintenance of the epithelial barrier function | Differential short palate, lung, and nasal epithelial clone 1 suppression in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps: implications for pathogenesis and treatment.
Wei Y, Han M, Wen W, Li H. | 09/24/2016 |
| High serum SPLUNC1 levels are associated with Pleural Effusion from Lung Cancer Compared to Tuberculosis. | SPLUNC1 Is a Significant Marker in Pleural Effusion from Lung Cancer Compared to Tuberculosis.
Xue JL, Yi L, Yan ZH, Li X, Wang XJ, Wei PJ, Zeng JE, Zhao YL, Zhang HT., Free PMC Article | 06/11/2016 |
| PLUNC is a protein of the tear film and suggest that it plays a role in fluid balance and surface tension regulation at the ocular surface. | Palate Lung Nasal Clone (PLUNC), a Novel Protein of the Tear Film: Three-Dimensional Structure, Immune Activation, and Involvement in Dry Eye Disease (DED).
Schicht M, Rausch F, Beron M, Jacobi C, Garreis F, Hartjen N, Beileke S, Kruse F, Bräuer L, Paulsen F. | 02/20/2016 |
| SPLUNC1 can weaken the inflammatory response induced by EBV infection in NPC cells through the regulation of the TLR9/NF-kappaB signaling pathway and control of the tumor inflammatory microenvironment | SPLUNC1 reduces the inflammatory response of nasopharyngeal carcinoma cells infected with the EB virus by inhibiting the TLR9/NF-κB pathway.
Ou C, Sun Z, Zhang H, Xiong W, Ma J, Zhou M, Lu J, Zeng Z, Bo X, Chen P, Li G, Li X, Li X. | 02/20/2016 |
| The G allele of rs1078761 may be detrimental to lung function in cystic fibrosis owing to decreased levels of BPIFA1 and BPIFB1. | Polymorphisms associated with expression of BPIFA1/BPIFB1 and lung disease severity in cystic fibrosis.
Saferali A, Obeidat M, Bérubé JC, Lamontagne M, Bossé Y, Laviolette M, Hao K, Nickle DC, Timens W, Sin DD, Postma DS, Strug LJ, Gallins PJ, Paré PD, Bingle CD, Sandford AJ. | 02/6/2016 |