| The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction. | The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction.
Ando S, Tanaka K, Matsumoto M, Oyama Y, Tomabechi Y, Yamagata A, Shirouzu M, Nakagawa R, Okimoto N, Taiji M, Sato K, Ohama T., Free PMC Article | 06/6/2024 |
| PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers. | PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers.
Aakula A, Isomursu A, Rupp C, Erickson A, Gupta N, Kauko O, Shah P, Padzik A, Pokharel YR, Kaur A, Li SP, Trotman L, Taimen P, Rannikko A, Lammerding J, Paatero I, Mirtti T, Ivaska J, Westermarck J., Free PMC Article | 06/14/2023 |
| DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p. | DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p.
Xu T, Lei T, Li SQ, Mai EH, Ding FH, Niu B., Free PMC Article | 02/13/2021 |
| Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1. | Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1.
Kauko O, Imanishi SY, Kulesskiy E, Yetukuri L, Laajala TD, Sharma M, Pavic K, Aakula A, Rupp C, Jumppanen M, Haapaniemi P, Ruan L, Yadav B, Suni V, Varila T, Corthals GL, Reimand J, Wennerberg K, Aittokallio T, Westermarck J., Free PMC Article | 12/12/2020 |
| Glycogen synthase kinase-3beta suppresses the expression of protein phosphatase methylesterase-1 through beta-catenin. | Glycogen synthase kinase-3β suppresses the expression of protein phosphatase methylesterase-1 through β-catenin.
Jin N, Shi R, Jiang Y, Chu D, Gong CX, Iqbal K, Liu F., Free PMC Article | 10/3/2020 |
| USP36 regulates PME-1 as a DUB and participates in the ERK and Akt signaling pathways | PME-1 is regulated by USP36 in ERK and Akt signaling pathways.
Kim SY, Choi J, Lee DH, Park JH, Hwang YJ, Baek KH. | 03/2/2019 |
| Authors found that PME-1 is exported from the nucleus to the cytoplasm upon H2O2 treatment and redistributes dem-p-PP2Ac in subcellular compartments. These findings offer new insight into the regulation of PME-1 localization and PP2A demethylation under oxidative stress. | Hydrogen peroxide redistributes the localization of protein phosphatase methylesterase 1.
Tang S, Lu C, Mo L, Wang X, Liang Z, Qin F, Liu Y, Liu Y, Huang H, Huang Y, Cai H, Xiao D, Guo S, Ouyang Y, Sun B, Li X. | 12/22/2018 |
| We demonstrate that NNMT outcompetes leucine carboxyl methyl transferase 1 (LCMT1) for methyl transfer from principal methyl donor SAM in biological systems. Inhibiting NNMT increased the availability of methyl groups for LCMT1 to methylate PP2A, resulting in the inhibition of oncogenic serine/threonine kinases (STK). | NNMT Silencing Activates Tumor Suppressor PP2A, Inactivates Oncogenic STKs, and Inhibits Tumor Forming Ability.
Palanichamy K, Kanji S, Gordon N, Thirumoorthy K, Jacob JR, Litzenberg KT, Patel D, Chakravarti A., Free PMC Article | 02/24/2018 |
| Studies indicate that protein phosphatase methylesterase-1 (PME-1) negatively regulates protein phosphatase 2A (PP2A) activity by highly complex mechanisms. | Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1.
Kaur A, Westermarck J. | 07/22/2017 |
| Data suggest that discovery of more potent protein phosphatase methylesterase-1 (PME-1) inhibitors may be beneficial for the treatment of endometrial cancer. | Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models.
Pusey M, Bail S, Xu Y, Buiakova O, Nestor M, Yang JJ, Rice LM. | 02/18/2017 |
| LCMT1-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division | A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size.
Xia X, Gholkar A, Senese S, Torres JZ., Free PMC Article | 04/23/2016 |
| this study suggests that the tightly linked regulatory loop comprised of the SIK2-PP2A and CaMKI and PME-1 networks may function in fine-tuning cell proliferation and stress response. | Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.
Lee CW, Yang FC, Chang HY, Chou H, Tan BC, Lee SC., Free PMC Article | 02/14/2015 |
| PPME1 could be an attractive therapeutic target for a subset of gastric cancer and lung cancer. | Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target.
Li J, Han S, Qian Z, Su X, Fan S, Fu J, Liu Y, Yin X, Gao Z, Zhang J, Yu DH, Ji Q., Free PMC Article | 09/6/2014 |
| Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled. | The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity.
Sents W, Ivanova E, Lambrecht C, Haesen D, Janssens V. | 04/13/2013 |
| GSK-3beta can inhibit PP2A by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 | Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.
Yao XQ, Li XC, Zhang XX, Yin YY, Liu B, Luo DJ, Wang Q, Wang JZ, Liu GP. | 10/13/2012 |
| Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. | Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF., Free PMC Article | 06/25/2011 |
| Observations identify PME-1 expression as one mechanism by which ERK pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas. | PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.
Puustinen P, Junttila MR, Vanhatupa S, Sablina AA, Hector ME, Teittinen K, Raheem O, Ketola K, Lin S, Kast J, Haapasalo H, Hahn WC, Westermarck J., Free PMC Article | 01/21/2010 |
| We propose that stabilization of this inactive, nuclear PP2A pool is a major in vivo function of PME-1. | Spatial control of protein phosphatase 2A (de)methylation.
Longin S, Zwaenepoel K, Martens E, Louis JV, Rondelez E, Goris J, Janssens V. | 01/21/2010 |