| Ring finger protein 138 inhibits transcription factor C/EBPalpha protein turnover leading to differentiation arrest in acute myeloid leukemia. | Ring finger protein 138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in acute myeloid leukemia.
Singh AK, Upadhyay V, Sethi A, Chowdhury S, Mishra S, Verma SP, Bhatt MLB, Trivedi AK. | 06/27/2024 |
| The role of RNF138 in DNA end resection is regulated by ubiquitylation and CDK phosphorylation. | The role of RNF138 in DNA end resection is regulated by ubiquitylation and CDK phosphorylation.
Locke AJ, Abou Farraj R, Tran C, Zeinali E, Mashayekhi F, Ali JYH, Glover JNM, Ismail IH., Free PMC Article | 04/15/2024 |
| RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex. | RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.
Liu W, Wang Z, Liu S, Zhang X, Cao X, Jiang M. | 10/5/2023 |
| The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells. | The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells.
Averbeck NB, Barent C, Jakob B, Syzonenko T, Durante M, Taucher-Scholz G., Free PMC Article | 09/3/2022 |
| RING finger 138 deregulation distorts NF-small ka, CyrillicB signaling and facilities colitis switch to aggressive malignancy. | RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy.
Lu Y, Huang R, Ying J, Li X, Jiao T, Guo L, Zhou H, Wang H, Tuersuntuoheti A, Liu J, Chen Q, Wang Y, Su L, Guo C, Xu F, Wang Z, Lu Y, Li K, Liang J, Huang Z, Chen X, Yao J, Hu H, Cheng X, Wan Y, Chen X, Zhang N, Miao S, Cai J, Wang L, Liu C, Song W, Zhao H., Free PMC Article | 06/18/2022 |
| African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1. | African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1.
Huang L, Xu W, Liu H, Xue M, Liu X, Zhang K, Hu L, Li J, Liu X, Xiang Z, Zheng J, Li C, Chen W, Bu Z, Xiong T, Weng C. | 12/4/2021 |
| Silencing microRNA29b3p expression protects human trabecular meshwork cells against oxidative injury via upregulation of RNF138 to activate the ERK pathway. | Silencing microRNA‑29b‑3p expression protects human trabecular meshwork cells against oxidative injury via upregulation of RNF138 to activate the ERK pathway.
Liu H, Xiu Y, Zhang Q, Xu Y, Wan Q, Tao L., Free PMC Article | 11/13/2021 |
| data suggest that RNF138 modulates the cisplatin resistance in the GC cells, thus serving as a potential drug target to challenge chemotherapy failure. In addition, RNF138 can also be used as a marker to monitor the development of cisplatin resistance in GC treatment. | RNF138 confers cisplatin resistance in gastric cancer cells via activating Chk1 signaling pathway.
Lu Y, Han D, Liu W, Huang R, Ou J, Chen X, Zhang X, Wang X, Li S, Wang L, Liu C, Miao S, Wang L, Ma C, Song W., Free PMC Article | 09/21/2019 |
| The role of RNF138 in glioblastoma and identify rpS3 as a crucial substrate of ubiquitination by RNF138, which underlies the radioresistance of glioblastoma. | RNF138-mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation-induced apoptosis.
Kim W, Youn H, Lee S, Kim E, Kim D, Sub Lee J, Lee JM, Youn B., Free PMC Article | 01/26/2019 |
| Study suggested that RNF138 was important for the proliferation, migration and invasion of glioma cells. Its downregulation inhibited the process of EMT by suppressing Erk signaling pathway in glioma. | Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway.
Wu H, Li X, Feng M, Yao L, Deng Z, Zao G, Zhou Y, Chen S, Du Z., Free PMC Article | 12/22/2018 |
| This study identify RNF138 as the E3 ubiquitin ligase promoting EA2-associated aberrant degradation of human CaV2.1 protein. | Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated Aberrant Degradation of Human Ca(v)2.1 (P/Q-Type) Calcium Channels.
Fu SJ, Jeng CJ, Ma CH, Peng YJ, Lee CM, Fang YC, Lee YC, Tang SC, Hu MC, Tang CY., Free PMC Article | 08/19/2017 |
| Rad51d mediated by E3 Ligase Rnf138 has a role in the homologous recombination repair pathway | Ubiquitylation of Rad51d Mediated by E3 Ligase Rnf138 Promotes the Homologous Recombination Repair Pathway.
Han D, Liang J, Lu Y, Xu L, Miao S, Lu LY, Song W, Wang L., Free PMC Article | 07/15/2017 |
| RNF138 is a newly identified regulatory component of the HR mediated DNA repair pathway that has implications toward understanding how ubiquitination modifies the functions of the RAD51 paralog protein complex | RNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity.
Yard BD, Reilly NM, Bedenbaugh MK, Pittman DL., Free PMC Article | 05/6/2017 |
| Data show that ubiquitin E2 enzymes UBE2D1/2/3 and E3 ligase RNF138 accumulate at DNA-damage sites and act at early resection stages by promoting CtIP protein ubiquitylation and accrual. | Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.
Schmidt CK, Galanty Y, Sczaniecka-Clift M, Coates J, Jhujh S, Demir M, Cornwell M, Beli P, Jackson SP., Free PMC Article | 03/19/2016 |
| Data show that ubiquitin E3 ligase RNF138 regulates Ku80 antigen ubiquitylation in response to DNA damage. | The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice.
Ismail IH, Gagné JP, Genois MM, Strickfaden H, McDonald D, Xu Z, Poirier GG, Masson JY, Hendzel MJ. | 03/19/2016 |
| The RNF138 gene is highly expressed in glioma tissue and glioma cell lines and plays an important role in glioma cell proliferation, apoptosis, and cell cycle. | A novel gene RNF138 expressed in human gliomas and its function in the glioma cell line U251.
Zhou YX, Chen SS, Wu TF, Ding DD, Chen XH, Chen JM, Su ZP, Li B, Chen GL, Xie XS, Dai YF, Wei YX, Du ZW., Free PMC Article | 01/26/2013 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| NARF functions as a novel ubiquitin-ligase to regulate ubiquitylation and degradation of T cell factor/lymphoid enhancer factor | NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).
Yamada M, Ohnishi J, Ohkawara B, Iemura S, Satoh K, Hyodo-Miura J, Kawachi K, Natsume T, Shibuya H. | 01/21/2010 |