| HSD17B7 gene in self-renewal and oncogenicity of keratinocytes from Black versus White populations. | HSD17B7 gene in self-renewal and oncogenicity of keratinocytes from Black versus White populations.
Xu X, Tassone B, Ostano P, Katarkar A, Proust T, Joseph JM, Riganti C, Chiorino G, Kutalik Z, Lefort K, Dotto GP., Free PMC Article | 10/30/2021 |
| Inhibition of 17beta-HSD7can provide a new basis for the design of combined endocrine therapy for breast cancer by controlling E2 and DHT, while up-regulating AR expression and stably controlling expression of ERalpha. | Mutual regulations and breast cancer cell control by steroidogenic enzymes: Dual sex-hormone receptor modulation upon 17β-HSD7 inhibition.
Sang X, Han H, Li T, Lin SX. | 01/18/2020 |
| Substrate affinity of 17beta-hydroxysteroid dehydrogenase type 7 toward estrone and 5alpha-dihydrotestosterone are similar. | The dual sex hormone specificity for human reductive 17β-hydroxysteroid dehydrogenase type 7: Synergistic function in estrogen and androgen control.
Thériault JF, Lin SX. | 05/25/2019 |
| Inhibition of 17beta-HSD 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78. | Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.
Wang XQ, Aka JA, Li T, Xu D, Doillon CJ, Lin SX. | 08/26/2017 |
| Substrate inhibition of 17beta-HSD1 in tumor epithelial cells and regulation of 17beta-HSD7 by 17beta-HSD1 knockdown has been demonstrated. | Substrate inhibition of 17β-HSD1 in living cells and regulation of 17β-HSD7 by 17β-HSD1 knockdown.
Han H, Thériault JF, Chen G, Lin SX. | 08/26/2017 |
| the dual functional 17beta-HSD7 is proposed as a novel target for estrogen-dependent breast cancer by regulating the balance of estradiol and dihydrotestosterone. | Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer.
Wang X, Gérard C, Thériault JF, Poirier D, Doillon CJ, Lin SX., Free PMC Article | 08/13/2016 |
| 17beta-HSD1 and 17beta-HSD7 are principal reductive 17beta-hydroxysteroid dehydrogenases and major players in the viability of estrogen-dependent breast cancer cells. | Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells.
Zhang CY, Wang WQ, Chen J, Lin SX. | 07/25/2015 |
| The transcriptional activity of the HSD17B7 gene containing the G allele is higher than that of the C allele. This difference in HSD17B7 expression may regulate the risk of peripheral edema as an adverse reaction induced by estramustine phosphate sodium | Single nucleotide polymorphisms of 17beta-hydroxysteroid dehydrogenase type 7 gene: mechanism of estramustine-related adverse reactions?
Ozeki T, Takeuchi M, Suzuki M, Kitamura T, Takayanagi R, Yokoyama H, Yamada Y. | 08/13/2014 |
| 17betaHSD7 is not the key enzyme responsible for androstenone and testosterone metabolism in porcine liver cells | Investigation of testosterone, androstenone, and estradiol metabolism in HepG2 cells and primary culture pig hepatocytes and their effects on 17βHSD7 gene expression.
Chen G, Li S, Dong X, Bai Y, Chen A, Yang S, Fang M, Zamaratskaia G, Doran O., Free PMC Article | 07/6/2013 |
| Data show that apicidin significantly lowers HSD17B1 transcript and protein levels in endometrial adenocarcinoma cells, with no significant effect on HSD17B1 transcript stability. | Apicidin suppresses transcription of 17β-hydroxysteroid dehydrogenase type 1 in endometrial adenocarcinoma cells.
Keleş E, Lianeri M, Jagodziński PP. | 10/22/2011 |
| estradiol stimulates HSD17B7 transcriptional activity in breast cancer cells through a novel mechanism requiring NF1 and strongly suggest a positive feedback mechanism, increasing estradiol synthesis causing growth of estrogen-dependent breast cancers | The stimulation of HSD17B7 expression by estradiol provides a powerful feed-forward mechanism for estradiol biosynthesis in breast cancer cells.
Shehu A, Albarracin C, Devi YS, Luther K, Halperin J, Le J, Mao J, Duan RW, Frasor J, Gibori G., Free PMC Article | 10/1/2011 |
| increased expression of HSD17B7 is associated with breast cancer. | Intratumoral estrogen disposition in breast cancer.
Haynes BP, Straume AH, Geisler J, A'Hern R, Helle H, Smith IE, Lønning PE, Dowsett M. | 06/28/2010 |
| There is no difference in catalytic properties between variants of 17beta-HSD types 7 and 12 and wild-type enzymes, while variants p.Glu77Gly and p.Lys183Arg in 17beta-HSD type 5 showed a slightly decreased activity. | Analysis of 17beta-hydroxysteroid dehydrogenase types 5, 7, and 12 genetic sequence variants in breast cancer cases from French Canadian Families with high risk of breast and ovarian cancer.
Plourde M, Ferland A, Soucy P, Hamdi Y, Tranchant M, Durocher F, Sinilnikova O, Luu The V, INHERIT BRCAs, Simard J. | 01/21/2010 |
| determined the activity and expression levels of known estrogenic 17beta-HSDs, namely types 1, 7 and 12 17beta-HSD in preadipocytes before and after differentiation into mature adipocytes | Differential estrogenic 17beta-hydroxysteroid dehydrogenase activity and type 12 17beta-hydroxysteroid dehydrogenase expression levels in preadipocytes and differentiated adipocytes.
Bellemare V, Laberge P, Noël S, Tchernof A, Luu-The V. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesGenetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer.
Li J, Eriksson L, Humphreys K, Czene K, Liu J, Tamimi RM, Lindström S, Hunter DJ, Vachon CM, Couch FJ, Scott CG, Lagiou P, Hall P. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
Ryckman KK, Morken NH, White MJ, Velez DR, Menon R, Fortunato SJ, Magnus P, Williams SM, Jacobsson B. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
Ehret GB, O'Connor AA, Weder A, Cooper RS, Chakravarti A. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.
Velez DR, Fortunato S, Thorsen P, Lombardi SJ, Williams SM, Menon R. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM. | 09/24/2008 |
| HSD17B7 is a novel candidate for inborn errors of cholesterol metabolism | Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R. | 01/21/2010 |
| 17-beta hydroxysteroid dehydrogenase type 7 (HSD17B7) -shRNA sequences were designed and tested for their effectiveness. | Functional analysis of cholesterol biosynthesis by RNA interference.
Guggenberger C, Ilgen D, Adamski J. | 01/21/2010 |
| The identified proximal promoter regions of both human and murine HSD17B7 genes contain multiple transcription factor binding sites and show strong similarity to cholesterogenic genes. | Analysis of the 5' flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region.
Ohnesorg T, Adamski J. | 01/21/2010 |
| Results provide unequivocal evidence for a role of 17beta-hydroxysteroid dehydrogenase type-7 in cholesterol biosynthesis. | Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis.
Ohnesorg T, Keller B, Hrabé de Angelis M, Adamski J. | 01/21/2010 |
| 17beta-hydroxysteroid dehydrogenase type 7(17beta-HSD type 7)was significantly upregulated in ovarian tissue of patients with ovarian endometriosis. | Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis.
Smuc T, Pucelj MR, Sinkovec J, Husen B, Thole H, Lanisnik Rizner T. | 01/21/2010 |
| Comparison of the promoter region of the human and murine gene. | Promoter analyses of human and mouse 17beta-hydroxysteroid dehydrogenase type 7.
Ohnesorg T, Adamski J. | 01/21/2010 |