| The habenular volume and PDE7A allelic polymorphism in major depressive disorder: preliminary findings. | The habenular volume and PDE7A allelic polymorphism in major depressive disorder: preliminary findings.
Aftanas LI, Filimonova EA, Anisimenko MS, Berdyugina DA, Rezakova MV, Simutkin GG, Bokhan NA, Ivanova SA, Danilenko KV, Lipina TV. | 03/13/2023 |
| Circ_0091702 relieves lipopolysaccharide (LPS)-induced cell injury by regulating the miR-182/PDE7A axis in sepsis. | Circ_0091702 relieves lipopolysaccharide (LPS)-induced cell injury by regulating the miR-182/PDE7A axis in sepsis.
Zhang X, Dong S. | 01/15/2022 |
| Long non-coding RNA TUSC7 suppressed colorectal cancer progression via regulation of miR-23b/PDE7A Axis. | Long non-coding RNA TUSC7 suppressed colorectal cancer progression via regulation of miR-23b/PDE7A Axis.
Hao L, Yun Y, Liang R, Yuan G. | 10/30/2021 |
| Phosphodiesterase 7 Regulation in Cellular and Rodent Models of Parkinson's Disease. | Phosphodiesterase 7 Regulation in Cellular and Rodent Models of Parkinson's Disease.
Morales-Garcia JA, Alonso-Gil S, Santos Á, Perez-Castillo A. | 11/21/2020 |
| Here we describe a compound, BC54, that is a selective inhibitor of enzymes from the cAMP-specific PDE4 and PDE7 families. Consistent with the biological effect of other PDE4 and PDE7 inhibitors, BC54 displays potent anti-inflammatory properties and is superior to a combination of rolipram (a PDE4 inhibitor) and BRL50481 (a PDE7A inhibitor) for inducing apoptosis in chronic lymphocytic leukemia (CLL) cells | Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays.
de Medeiros AS, Wyman AR, Alaamery MA, Allain C, Ivey FD, Wang L, Le H, Morken JP, Habara A, Le C, Cui S, Lerner A, Hoffman CS., Free PMC Article | 06/16/2018 |
| Low PDE7A expression is associated with sepsis. | Leukocyte phosphodiesterase expression after lipopolysaccharide and during sepsis and its relationship with HLA-DR expression.
Lelubre C, Medfai H, Akl I, Leentjens J, Kox M, Pickkers P, Rousseau A, Biston P, Piagnerelli M, Vanhaeverbeek M, Uzureau P, Vincent JL, Vanhamme L, Boudjeltia KZ. | 09/16/2017 |
| PDE7A is a high-speed and low-affinity phosphodiesterase for cCMP. | PDE7A1 hydrolyzes cCMP.
Monzel M, Kuhn M, Bähre H, Seifert R, Schneider EH. | 11/22/2014 |
| PDE7 has roles in regulating oligodendrocyte precursor survival and differentiation during brain development and in adulthood | Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival.
Medina-Rodríguez EM, Arenzana FJ, Pastor J, Redondo M, Palomo V, García de Sola R, Gil C, Martínez A, Bribián A, de Castro F., Free PMC Article | 11/16/2013 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| results show that specific gene silencing with the RNAi method is a useful tool for inhibiting the gene expression of specific PDEs and that PDE7 silencing upregulates several osteogenic genes and increases mineralization | Effects of phosphodiesterase 7 inhibition by RNA interference on the gene expression and differentiation of human mesenchymal stem cell-derived osteoblasts.
Pekkinen M, Ahlström MEB, Riehle U, Huttunen MM, Lamberg-Allardt CJE. | 01/21/2010 |
| crystal structure of PDE7A1 catalytic domain complexed with the inhibitor 3-isobutyl-1-methylxanthine & kinetic analysis on mutant PDE7A1 and PDE4D2; results show several residues must work together to switch inhibitor selectivity between PDE4 & PDE7 | Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.
Wang H, Liu Y, Chen Y, Robinson H, Ke H. | 01/21/2010 |
| PDE7 has the potential to regulate human T cell function including cytokine production, proliferation and expression of activation markers. | Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors.
Nakata A, Ogawa K, Sasaki T, Koyama N, Wada K, Kotera J, Kikkawa H, Omori K, Kaminuma O., Free PMC Article | 01/21/2010 |
| Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells; PDE7A was expressed in neutrophils and alveolar macrophages | Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells.
Smith SJ, Brookes-Fazakerley S, Donnelly LE, Barnes PJ, Barnette MS, Giembycz MA. | 01/21/2010 |