| AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction. | AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.
Qasim H, Rajaei M, Xu Y, Reyes-Alcaraz A, Abdelnasser HY, Stewart MD, Lahiri SK, Wehrens XHT, McConnell BK., Free PMC Article | 05/1/2024 |
| 14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway. | 14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway.
Mukherjee S, Roy S, Mukherjee S, Harikishore A, Bhunia A, Mandal AK., Free PMC Article | 04/11/2024 |
| cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor. | cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.
Campolo F, Capponi C, Tarsitano MG, Tenuta M, Pozza C, Gianfrilli D, Magliocca F, Venneri MA, Vicini E, Lenzi A, Isidori AM, Barbagallo F., Free PMC Article | 10/29/2022 |
| Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells. | Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells.
Turner MJ, Sato Y, Thomas DY, Abbott-Banner K, Hanrahan JW. | 02/12/2022 |
| Phosphodiesterase 8A to discriminate in blood samples depressed patients and suicide attempters from healthy controls based on A-to-I RNA editing modifications. | Phosphodiesterase 8A to discriminate in blood samples depressed patients and suicide attempters from healthy controls based on A-to-I RNA editing modifications.
Salvetat N, Chimienti F, Cayzac C, Dubuc B, Checa-Robles F, Dupre P, Mereuze S, Patel V, Genty C, Lang JP, Pujol JF, Courtet P, Weissmann D., Free PMC Article | 08/21/2021 |
| Editing of PDE8A mRNA displayed clear regional difference when comparing dorsolateral prefrontal cortex (BA9) and anterior cingulate cortex (BA24). There were significant intra-regional differences between non-psychiatric control individuals and depressed suicide decedents. | Brain region-specific alterations of RNA editing in PDE8A mRNA in suicide decedents.
Chimienti F, Cavarec L, Vincent L, Salvetat N, Arango V, Underwood MD, Mann JJ, Pujol JF, Weissmann D., Free PMC Article | 01/18/2020 |
| PDE8 is expressed in lipid rafts of human airway smooth muscle cells(HASM), where it specifically regulates beta2-adrenergic receptor/ AC6 signaling to modulate HASM responsiveness and airway remodeling in asthma. | PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β(2)-Adrenergic Receptors and Adenylyl Cyclase 6.
Johnstone TB, Smith KH, Koziol-White CJ, Li F, Kazarian AG, Corpuz ML, Shumyatcher M, Ehlert FJ, Himes BE, Panettieri RA Jr, Ostrom RS., Free PMC Article | 07/13/2019 |
| SNPs within genes SCHIP1 and PDE8A were associated with measures of facial size in both the GWAS and replication cohorts and passed a stringent genomewide significance threshold adjusted for multiple testing of 34 correlated traits. For both SCHIP1 and PDE8A, we demonstrated clear expression in the developing mouse face by both whole-mount in situ hybridization and RNA-seq | Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape.
Cole JB, Manyama M, Kimwaga E, Mathayo J, Larson JR, Liberton DK, Lukowiak K, Ferrara TM, Riccardi SL, Li M, Mio W, Prochazkova M, Williams T, Li H, Jones KL, Klein OD, Santorico SA, Hallgrimsson B, Spritz RA., Free PMC Article | 05/27/2017 |
| PDE8A supports HIV-1 replication in macrophages | Phosphodiesterase 8a supports HIV-1 replication in macrophages at the level of reverse transcription.
Booiman T, Cobos Jiménez V, van Dort KA, van 't Wout AB, Kootstra NA., Free PMC Article | 10/10/2015 |
| a novel and critical role for phosphodiesterases in moderating local concentrations of cAMP in microdomains and signal resetting | Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.
Krishnamurthy S, Moorthy BS, Xin Xiang L, Xin Shan L, Bharatham K, Tulsian NK, Mihalek I, Anand GS., Free PMC Article | 02/21/2015 |
| PDE8A can bind tightly to Raf-1, regulate Raf-1 phosphorylation on S259, and, in so doing, regulate the cross-talk node whereby cAMP exerts an inhibitory effect on Raf-1 signaling, retarding subsequent ERK phosphorylation and activation. | Phosphodiesterase-8A binds to and regulates Raf-1 kinase.
Brown KM, Day JP, Huston E, Zimmermann B, Hampel K, Christian F, Romano D, Terhzaz S, Lee LC, Willis MJ, Morton DB, Beavo JA, Shimizu-Albergine M, Davies SA, Kolch W, Houslay MD, Baillie GS., Free PMC Article | 06/22/2013 |
| PDE8 activity can be modulated by a kinase | Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation.
Brown KM, Lee LC, Findlay JE, Day JP, Baillie GS. | 08/11/2012 |
| Polymorphism in PDE8A affects HIV-1 replication in primary macrophages. | Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages.
Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, Strauss JF 3rd, Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB. | 11/19/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| The findings exclude a significant role for PDE8A as a PCOS candidate gene, and as a Las major determinant of androgen levels in women. | PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women.
Chen C, Wickenheisser J, Ewens KG, Ankener W, Legro RS, Dunaif A, McAllister JM, Spielman RS, Strauss JF 3rd, Chen C, Wickenheisser J, Ewens KG, Ankener W, Legro RS, Dunaif A, McAllister JM, Spielman RS, Strauss JF 3rd., Free PMC Articles: PMC2709315, PMC2709315 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women.
Chen C, Wickenheisser J, Ewens KG, Ankener W, Legro RS, Dunaif A, McAllister JM, Spielman RS, Strauss JF 3rd, Chen C, Wickenheisser J, Ewens KG, Ankener W, Legro RS, Dunaif A, McAllister JM, Spielman RS, Strauss JF 3rd. | 06/24/2009 |
| kinetic properties of the highly active PDE8A1 catalytic domain prepared from refolding and its crystal structures in the unliganded and 3-isobutyl-1-methylxanthine (IBMX) bound forms at 1.9 and 2.1 A resolutions | Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity.
Wang H, Yan Z, Yang S, Cai J, Robinson H, Ke H., Free PMC Article | 01/21/2010 |
| Comparison of enzymatic characterization and gene organization of PDE8B and PDE8A. | Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans.
Gamanuma M, Yuasa K, Sasaki T, Sakurai N, Kotera J, Omori K. | 01/21/2010 |
| in vitro and in vivo experiments demonstrated that the association with IkappaB greatly enhanced the enzyme activity of PDE8A1 | Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IkappaB proteins.
Wu P, Wang P., Free PMC Article | 01/21/2010 |