| The findings suggest that SPIN90, as an adaptor protein, simultaneously binds inactive Rab5 and Gapex5, thereby altering their spatial proximity and facilitating Rab5 activation. | SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis.
Kim H, Oh H, Oh YS, Bae J, Hong NH, Park SJ, Ahn S, Lee M, Rhee S, Lee SH, Jun Y, Kim SH, Huh YH, Song WK., Free PMC Article | 06/27/2020 |
| Structure of the nucleation-promoting factor SPIN90 bound to the actin filament nucleator Arp2/3 complex. | Structure of the nucleation-promoting factor SPIN90 bound to the actin filament nucleator Arp2/3 complex.
Luan Q, Liu SL, Helgeson LA, Nolen BJ., Free PMC Article | 10/5/2019 |
| Low SPIN90 expression is associated with Breast Cancer. | SPIN90 Depletion and Microtubule Acetylation Mediate Stromal Fibroblast Activation in Breast Cancer Progression.
You E, Huh YH, Kwon A, Kim SH, Chae IH, Lee OJ, Ryu JH, Park MH, Kim GE, Lee JS, Lee KH, Lee YS, Kim JW, Rhee S, Song WK. | 11/4/2017 |
| findings suggest that SPIN90 contributes to the formation and movement of endosomal vesicles, and modulates the stability of EGFR protein, which affects cell cycle progression | SPIN90 knockdown attenuates the formation and movement of endosomal vesicles in the early stages of epidermal growth factor receptor endocytosis.
Oh H, Kim H, Chung KH, Hong NH, Shin B, Park WJ, Jun Y, Rhee S, Song WK., Free PMC Article | 09/20/2014 |
| SPIN90 dephosphorylation is a prerequisite step for releasing cofilin so that cofilin can adequately sever actin filaments into monomeric form. | SPIN90 dephosphorylation is required for cofilin-mediated actin depolymerization in NMDA-stimulated hippocampal neurons.
Cho IH, Lee MJ, Kim DH, Kim B, Bae J, Choi KY, Kim SM, Huh YH, Lee KH, Kim CH, Song WK., Free PMC Article | 12/21/2013 |
| Findings show that SPIN90 modulates synaptic activity in neurons as a result of its phosphorylation. | SPIN90 phosphorylation modulates spine structure and synaptic function.
Cho IH, Kim DH, Lee MJ, Bae J, Lee KH, Song WK., Free PMC Article | 08/3/2013 |
| Dia2 and DIP co-tether to nascent blebs and this linkage is required for bleb formation. | Dia-interacting protein (DIP) imposes migratory plasticity in mDia2-dependent tumor cells in three-dimensional matrices.
Wyse MM, Lei J, Nestor-Kalinoski AL, Eisenmann KM., Free PMC Article | 02/16/2013 |
| SPIN90 and IRSp53 positively cooperated to mediate Rac activation, and co-expression of SPIN90 and IRSp53 in COS-7 cells led to the complex formation of SPIN90-IRSp53 in the leading edge of cells | SPIN90-IRSp53 complex participates in Rac-induced membrane ruffling.
Teodorof C, Bae JI, Kim SM, Oh HJ, Kang YS, Choi J, Chun JS, Song WK. | 01/21/2010 |
| DIP binds to and inhibits actin assembly by the FH2 domain of the formin mDia2 | Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex.
Eisenmann KM, Harris ES, Kitchen SM, Holman HA, Higgs HN, Alberts AS, Eisenmann KM, Harris ES, Kitchen SM, Holman HA, Higgs HN, Alberts AS. | 05/22/2009 |
| The interplay between palladin, SPIN90 and Src and characterized the role of palladin and SPIN90 in platelet derived growth factor and Src-induced cytoskeletal remodeling, was analyzed. | Palladin interacts with SH3 domains of SPIN90 and Src and is required for Src-induced cytoskeletal remodeling.
Rönty M, Taivainen A, Heiska L, Otey C, Ehler E, Song WK, Carpen O., Free PMC Article | 01/21/2010 |
| the interaction of the betaPIX.WASP.SPIN90 complex with Nck is crucial for stable cell adhesion and can be dynamically modulated by SPIN90 phosphorylation that is dependent on cell adhesion and ERK activation | Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion.
Lim CS, Kim SH, Jung JG, Kim JK, Song WK. | 01/21/2010 |
| SPIN90 participates in reorganization of the actin cytoskeleton and in actin-based cell motility | Interaction of SPIN90 with the Arp2/3 complex mediates lamellipodia and actin comet tail formation.
Kim DJ, Kim SH, Lim CS, Choi KY, Park CS, Sung BH, Yeo MG, Chang S, Kim JK, Song WK. | 01/21/2010 |
| These observations point to a pivotal role for DIP in the control of nonbranched and branched actin-filament assembly that is mediated by Diaphanous-related formins and activators of Arp2/3, respectively. | Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex.
Eisenmann KM, Harris ES, Kitchen SM, Holman HA, Higgs HN, Alberts AS, Eisenmann KM, Harris ES, Kitchen SM, Holman HA, Higgs HN, Alberts AS. | 01/21/2010 |