| Inhibition of UFM1 expression suppresses cancer progression and is linked to the dismal prognosis and immune infiltration in oral squamous cell carcinoma. | Inhibition of UFM1 expression suppresses cancer progression and is linked to the dismal prognosis and immune infiltration in oral squamous cell carcinoma.
Ke D, Guo HH, Jiang N, Shi RS, Fan TY., Free PMC Article | 12/15/2023 |
| Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control. | Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control.
Ishimura R, Ito S, Mao G, Komatsu-Hirota S, Inada T, Noda NN, Komatsu M., Free PMC Article | 08/25/2023 |
| Modification of PLAC8 by UFM1 affects tumorous proliferation and immune response by impacting PD-L1 levels in triple-negative breast cancer. | Modification of PLAC8 by UFM1 affects tumorous proliferation and immune response by impacting PD-L1 levels in triple-negative breast cancer.
Mao M, Chen Y, Yang J, Cheng Y, Xu L, Ji F, Zhou J, Zhang X, Li Z, Chen C, Ju S, Zhang J, Wang L., Free PMC Article | 01/14/2023 |
| Emerging role of protein modification by UFM1 in cancer. | Emerging role of protein modification by UFM1 in cancer.
Chung CH, Yoo HM. | 11/19/2022 |
| Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation. | Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation.
Millrine D, Cummings T, Matthews SP, Peter JJ, Magnussen HM, Lange SM, Macartney T, Lamoliatte F, Knebel A, Kulathu Y., Free PMC Article | 08/13/2022 |
| Modification of ERalpha by UFM1 Increases Its Stability and Transactivity for Breast Cancer Development. | Modification of ERα by UFM1 Increases Its Stability and Transactivity for Breast Cancer Development.
Yoo HM, Park JH, Kim JY, Chung CH., Free PMC Article | 06/18/2022 |
| Structure and dynamics of UBA5-UFM1 complex formation showing new insights in the UBA5 activation mechanism. | Structure and dynamics of UBA5-UFM1 complex formation showing new insights in the UBA5 activation mechanism.
Fuchs S, Kikhney AG, Schubert R, Kaiser C, Liebau E, Svergun DI, Betzel C, Perbandt M. | 04/2/2022 |
| Structural basis for UFM1 transfer from UBA5 to UFC1. | Structural basis for UFM1 transfer from UBA5 to UFC1.
Kumar M, Padala P, Fahoum J, Hassouna F, Tsaban T, Zoltsman G, Banerjee S, Cohen-Kfir E, Dessau M, Rosenzweig R, Isupov MN, Schueler-Furman O, Wiener R., Free PMC Article | 10/23/2021 |
| Decrypting UFMylation: How Proteins Are Modified with UFM1. | Decrypting UFMylation: How Proteins Are Modified with UFM1.
Banerjee S, Kumar M, Wiener R., Free PMC Article | 09/11/2021 |
| A Concerted Action of UBA5 C-Terminal Unstructured Regions Is Important for Transfer of Activated UFM1 to UFC1. | A Concerted Action of UBA5 C-Terminal Unstructured Regions Is Important for Transfer of Activated UFM1 to UFC1.
Wesch N, Löhr F, Rogova N, Dötsch V, Rogov VV., Free PMC Article | 08/14/2021 |
| A homozygous UBA5 pathogenic variant causes a fatal congenital neuropathy. | A homozygous UBA5 pathogenic variant causes a fatal congenital neuropathy.
Cabrera-Serrano M, Coote DJ, Azmanov D, Goullee H, Andersen E, McLean C, Davis M, Ishimura R, Stark Z, Vallat JM, Komatsu M, Kornberg A, Ryan M, Laing NG, Ravenscroft G. | 07/10/2021 |
| The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I. | The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I.
Schuren ABC, Boer IGJ, Bouma EM, Van de Weijer ML, Costa AI, Hubel P, Pichlmair A, Lebbink RJ, Wiertz EJHJ., Free PMC Article | 04/13/2021 |
| Stimulates transfer of UFM1 from UBA5 to the E2, UFC1. | An N-Terminal Extension to UBA5 Adenylation Domain Boosts UFM1 Activation: Isoform-Specific Differences in Ubiquitin-like Protein Activation.
Soudah N, Padala P, Hassouna F, Kumar M, Mashahreh B, Lebedev AA, Isupov MN, Cohen-Kfir E, Wiener R. | 03/7/2020 |
| Low UFM1 expression is associated with gastric cancer invasiveness. | UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expres7sion of PDK1 through PI3K/AKT signaling.
Lin JX, Xie XS, Weng XF, Qiu SL, Yoon C, Lian NZ, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Yang YH, Huang CM, Zheng CH, Li P., Free PMC Article | 02/22/2020 |
| MRE11-mediated UFMylation promotes ATM activation. | MRE11 UFMylation promotes ATM activation.
Wang Z, Gong Y, Peng B, Shi R, Fan D, Zhao H, Zhu M, Zhang H, Lou Z, Zhou J, Zhu WG, Cong YS, Xu X., Free PMC Article | 11/30/2019 |
| UFM1 conjugation plays an essential role in DNA damage response. (Review) | Essential Role of Ubiquitin-Fold Modifier 1 Conjugation in DNA Damage Response.
Fang Z, Pan Z. | 10/19/2019 |
| that the Ufm1 system is essential for cardiac homeostasis through regulation of endoplasmic reticulum function and that upregulation of myocardial Ufl1 could be protective against heart failure | Ufm1-Specific Ligase Ufl1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against Heart Failure.
Li J, Yue G, Ma W, Zhang A, Zou J, Cai Y, Tang X, Wang J, Liu J, Li H, Su H., Free PMC Article | 08/17/2019 |
| results make a connection between the binding of UFM1 to UBA5 and the latter's affinity to ATP, so we propose a novel mechanism for the regulation of ATP's binding to E1. | Trans-binding of UFM1 to UBA5 stimulates UBA5 homodimerization and ATP binding.
Mashahreh B, Hassouna F, Soudah N, Cohen-Kfir E, Strulovich R, Haitin Y, Wiener R. | 01/5/2019 |
| UFM1 His 70 resembles UBA5 His336 and enters a negatively charged pocked on the other UFM1 molecule. | Novel insights into the interaction of UBA5 with UFM1 via a UFM1-interacting sequence.
Padala P, Oweis W, Mashahreh B, Soudah N, Cohen-Kfir E, Todd EA, Berndsen CE, Wiener R., Free PMC Article | 09/8/2018 |
| Ufmylation may participate in regulation of the vascular smooth muscle cells phenotypic switch and endothelial cell injury, which may help in the understanding of vascular remodeling. | Ufmylation Is Activated in Vascular Remodeling and Lipopolysaccharide-Induced Endothelial Cell Injury.
Su M, Yue Z, Wang H, Jia M, Bai C, Qiu W, Chen J. | 05/26/2018 |
| These findings explicitly elucidate the role of UBA5 dimerization in UFM1 activation. | Trans-Binding Mechanism of Ubiquitin-like Protein Activation Revealed by a UBA5-UFM1 Complex.
Oweis W, Padala P, Hassouna F, Cohen-Kfir E, Gibbs DR, Todd EA, Berndsen CE, Wiener R. | 02/10/2018 |
| This study, focused on identifying the mutated gene in patients with hypomyelination with atrophy of the basal ganglia and cerebellum without TUBB4A mutations, revealed a homozygous 3-bp deletion in the UFM1 promoter area, which perfectly segregates with the disease. | UFM1 founder mutation in the Roma population causes recessive variant of H-ABC.
Hamilton EMC, Bertini E, Kalaydjieva L, Morar B, Dojčáková D, Liu J, Vanderver A, Curiel J, Persoon CM, Diodato D, Pinelli L, van der Meij NL, Plecko B, Blaser S, Wolf NI, Waisfisz Q, Abbink TEM, van der Knaap MS, Recessive H-ABC Research Group., Free PMC Article | 11/4/2017 |
| Meta analysis identified a new gene, UFM1, that is associated with low von Willebrand factor levels. | Genome-wide association studies identify genetic loci for low von Willebrand factor levels.
van Loon J, Dehghan A, Weihong T, Trompet S, McArdle WL, Asselbergs FW, Chen MH, Lopez LM, Huffman JE, Leebeek FW, Basu S, Stott DJ, Rumley A, Gansevoort RT, Davies G, Wilson JJ, Witteman JC, Cao X, de Craen AJ, Bakker SJ, Psaty BM, Starr JM, Hofman A, Wouter Jukema J, Deary IJ, Hayward C, van der Harst P, Lowe GD, Folsom AR, Strachan DP, Smith N, de Maat MP, O'Donnell C., Free PMC Article | 07/29/2017 |
| in the absence of UFSP2, a deconjugating enzyme for UFM1, ectopic expression of both UFL1 and UFBP1, which serve as the E3-ligase complex for the UFM1-system, dramatically increases UFM1-conjugate formation at the endoplasmic reticulum. | A novel approach to assess the ubiquitin-fold modifier 1-system in cells.
Ishimura R, Obata M, Kageyama S, Daniel J, Tanaka K, Komatsu M. | 05/27/2017 |
| Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy | Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy.
Colin E, Daniel J, Ziegler A, Wakim J, Scrivo A, Haack TB, Khiati S, Denommé AS, Amati-Bonneau P, Charif M, Procaccio V, Reynier P, Aleck KA, Botto LD, Herper CL, Kaiser CS, Nabbout R, N'Guyen S, Mora-Lorca JA, Assmann B, Christ S, Meitinger T, Strom TM, Prokisch H, FREX Consortium, Miranda-Vizuete A, Hoffmann GF, Lenaers G, Bomont P, Liebau E, Bonneau D., Free PMC Article | 05/6/2017 |