| Nemo-like kinase blocks myeloid differentiation by targeting tumor suppressor C/EBPalpha in AML. | Nemo-like kinase blocks myeloid differentiation by targeting tumor suppressor C/EBPα in AML.
Singh AK, Thacker G, Upadhyay V, Mishra M, Sharma A, Sethi A, Chowdhury S, Siddiqui S, Verma SP, Pandey A, Bhatt MLB, Trivedi AK. | 10/25/2024 |
| Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration. | Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration.
Tejwani L, Jung Y, Kokubu H, Sowmithra S, Ni L, Lee C, Sanders B, Lee PJ, Xiang Y, Luttik K, Soriano A, Yoon J, Park J, Ro HH, Ju H, Liao C, Tieze SM, Rigo F, Jafar-Nejad P, Lim J., Free PMC Article | 08/19/2023 |
| Somatic Mutations and Intratumoral Heterogeneity of Cancer-Related Genes NLK, YY1 and PA2G4 in Gastric and Colorectal Cancers. | Somatic Mutations and Intratumoral Heterogeneity of Cancer-Related Genes NLK, YY1 and PA2G4 in Gastric and Colorectal Cancers.
Son HJ, Choi EJ, Yoo NJ, Lee SH. | 07/17/2021 |
| NLK interacts with 1433zeta to restore the expression of Ecadherin. | NLK interacts with 14‑3‑3ζ to restore the expression of E‑cadherin.
Chen J, Lin Q, Ni T, Zhao J, Lin F, Lu X, Lv Y, Ren S, Liu Z, Zhang T, He S, Shen D, Mao W., Free PMC Article | 10/24/2020 |
| Effect of NLK on the proliferation and invasion of laryngeal carcinoma cells by regulating CDCP1. | Effect of NLK on the proliferation and invasion of laryngeal carcinoma cells by regulating CDCP1.
Shen N, Duan XH, Wang XL, Yang QY, Feng Y, Zhang JX. | 10/3/2020 |
| Overexpression of Nemo-like Kinase Promotes the Proliferation and Invasion of Lung Cancer Cells and Indicates Poor Prognosis. | Overexpression of Nemo-like Kinase Promotes the Proliferation and Invasion of Lung Cancer Cells and Indicates Poor Prognosis.
Lei L, Wang Y, Zheng YW, Fei LR, Shen HY, Li ZH, Huang WJ, Yu JH, Xu HT. | 09/26/2020 |
| Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase. | Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.
Wilkes MC, Siva K, Chen J, Varetti G, Youn MY, Chae H, Ek F, Olsson R, Lundbäck T, Dever DP, Nishimura T, Narla A, Glader B, Nakauchi H, Porteus MH, Repellin CE, Gazda HT, Lin S, Serrano M, Flygare J, Sakamoto KM., Free PMC Article | 08/29/2020 |
| Low NLK expression is associated with metastasis in nonsmallcell lung cancer. | Knockdown of Nemo‑like kinase promotes metastasis in non‑small‑cell lung cancer.
Shi C, Xu L, Tang Z, Zhang W, Wei Y, Ni J, Zhang S, Feng J., Free PMC Article | 01/25/2020 |
| Nemo like kinase (NLK) interacts with and phosphorylates mitochondrial antiviral signaling protein (MAVS), and a peptide derived from MAVS promotes viral-induced interferon beta (IFN-beta) production and antagonizes viral replication. | Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response.
Li SZ, Shu QP, Song Y, Zhang HH, Liu Y, Jin BX, Liuyu TZ, Li C, Huang XC, Du RL, Song W, Zhong B, Zhang XD., Free PMC Article | 01/4/2020 |
| NLK boosts cell proliferation and E2F1 activity and controls the cell cycle switch by releasing HDAC1 from the E2F1 complex, us priming colorectal cancer progression | Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1.
Li SZ, Zeng F, Li J, Shu QP, Zhang HH, Xu J, Ren JW, Zhang XD, Song XM, Du RL. | 09/14/2019 |
| the promoters of WIF1, NLK, and APC are highly methylated in the nasopharyngeal cancers (NPC) and gastric carcinoma (GC) cell lines, and the 3 genes are also regulated by miR-BART19-3p expressed by Epstein-Barr virus (EBV); expression of the WIF1, APC, and NLK genes is strongly affected by hypermethylation, and in EBV-associated tumors, the 3 genes are also affected by miR-BART19-3p | The effect of EBV on WIF1, NLK, and APC gene methylation and expression in gastric carcinoma and nasopharyngeal cancer.
Zhao Z, Liu W, Liu J, Wang J, Luo B. | 04/7/2018 |
| overexpression of miR-221 decreased LEF1 phosphorylation but increased the expression of MYCN via targeting of NLK and further regulated cell cycle, particularly in S-phase. This study provides a novel insight for miR-221 in the control of neuroblastoma cell proliferation and tumorigenesis, suggesting potentials of miR-221 as a prognosis marker and therapeutic target for patients with MYCN overexpressing neuroblastoma. | microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma.
He XY, Tan ZL, Mou Q, Liu FJ, Liu S, Yu CW, Zhu J, Lv LY, Zhang J, Wang S, Bao LM, Peng B, Zhao H, Zou L. | 03/17/2018 |
| our data suggest that NLK/Nemo acts as an endogenous regulator of Hippo signaling by controlling nuclear localization and activity of YAP/Yorkie. | Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization.
Moon S, Kim W, Kim S, Kim Y, Song Y, Bilousov O, Kim J, Lee T, Cha B, Kim M, Kim H, Katanaev VL, Jho EH., Free PMC Article | 08/19/2017 |
| NLK is a novel signaling molecule for proper lung development through the interconnection between epithelial and endothelial cells during lung morphogenesis | Nemo-like kinase regulates the expression of vascular endothelial growth factor (VEGF) in alveolar epithelial cells.
Ke H, Masoumi KC, Ahlqvist K, Seckl MJ, Rydell-Törmänen K, Massoumi R., Free PMC Article | 04/8/2017 |
| Our results suggest that NLK inhibits transcriptional activation of Nurr1 gene by impeding CBP's role as a co-activator of NF-kappaB and CREB in prostate cancer. | Nemo-like kinase as a negative regulator of nuclear receptor Nurr1 gene transcription in prostate cancer.
Wang J, Yang ZH, Chen H, Li HH, Chen LY, Zhu Z, Zou Y, Ding CC, Yang J, He ZW., Free PMC Article | 12/17/2016 |
| The expression of NLK was negatively correlated with TCF4 expression in lung cancers | Expression of Nemo-like kinase was increased and negatively correlated with the expression of TCF4 in lung cancers.
Zhang XW, Chen SY, Xue DW, Xu HH, Yang LH, Xu HT, Wang EH., Free PMC Article | 11/5/2016 |
| NLK overexpression is an independent prognostic factor in colorectal cancer and knockdown of NLK expression inhibits colorectal cancer progression and metastasis. | Upregulation of nemo-like kinase is an independent prognostic factor in colorectal cancer.
Zhang W, He J, Du Y, Gao XH, Liu Y, Liu QZ, Chang WJ, Cao GW, Fu CG., Free PMC Article | 10/8/2016 |
| Further experiments demonstrated that the overexpression of miR3623p resulted in decrease expression levels of nemo-like kinase | miR-362-3p targets nemo-like kinase and functions as a tumor suppressor in renal cancer cells.
Zou X, Zhong J, Li J, Su Z, Chen Y, Deng W, Li Y, Lu S, Lin Y, Luo L, Li Z, Cai Z, Tang A. | 10/8/2016 |
| NLK was involved in miR-92b-induced cell proliferation, and its protein level was obviously downregulated in the miR-92b-overexpressing xenograft tumors. | MicroRNA-92b promotes tumor growth and activation of NF-κB signaling via regulation of NLK in oral squamous cell carcinoma.
Liu Z, Diep C, Mao T, Huang L, Merrill R, Zhang Z, Peng Y. | 08/13/2016 |
| Data show that metformin inhibits nemo like kinase (NLK) expression and might be a potential treatment strategy for non-small cell lung cancer (NSCLC). | NLK functions to maintain proliferation and stemness of NSCLC and is a target of metformin.
Suwei D, Liang Z, Zhimin L, Ruilei L, Yingying Z, Zhen L, Chunlei G, Zhangchao L, Yuanbo X, Jinyan Y, Gaofeng L, Xin S., Free PMC Article | 07/16/2016 |
| Down-regulation of NLK inhibited tumorigenesis and up-regulated the expression of cell cycle proteins in laryngeal cancer cells. | Lentivirus‑delivered nemo‑like kinase small interfering RNA inhibits laryngeal cancer cell proliferation in vitro.
Tai J, Rao Y, Fang J, Huang Z, Yu Z, Chen X, Zhou W, Xiao X, Long T, Han Y, Liu Q, Li A, Ni X., Free PMC Article | 06/28/2016 |
| In this review, we will make a summary on the comprehensive roles of NLK in the regulation of various cancers | The emerging role of Nemo-like kinase (NLK) in the regulation of cancers.
Huang Y, Yang Y, He Y, Li J. | 04/23/2016 |
| NLK was an identified miR-199a-3p target gene and functioned as a tumor suppressor gene in colorectal cancer. | NLK, a novel target of miR-199a-3p, functions as a tumor suppressor in colorectal cancer.
Han Y, Kuang Y, Xue X, Guo X, Li P, Wang X, Guo X, Yuan B, Zhi Q, Zhao H. | 04/23/2016 |
| NLK overexpression is associated with poor overall survival in patients with hepatocellular carcinoma(HCC), it might be an independent poor prognostic marker for HCC. | Prognostic significance of Nemo-like kinase expression in patients with hepatocellular carcinoma.
Chen HW, Qiao HY, Li HC, Li ZF, Zhang HJ, Pei L, Liu HW, Jin L, Wang D, Li JL. | 04/9/2016 |
| NLK phosphorylates Raptor on S863 to disrupt its interaction with the Rag GTPase, which is important for mTORC1 lysosomal recruitment. | NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.
Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, Guan KL., Free PMC Article | 03/5/2016 |