| Heterozygous MAP3K20 variants cause ectodermal dysplasia, craniosynostosis, sensorineural hearing loss, and limb anomalies. | Heterozygous MAP3K20 variants cause ectodermal dysplasia, craniosynostosis, sensorineural hearing loss, and limb anomalies.
Brooks D, Burke E, Lee S, Eble TN, O'Leary M, Osei-Owusu I, Rehm HL, Dhar SU, Emrick L, Bick D, Nehrebecky M, Macnamara E, Casas-Alba D, Armstrong J, Prat C, Martínez-Monseny AF, Palau F, Liu P, Adams D, Undiagnosed Diseases Network, Lalani S, Rosenfeld JA, Burrage LC., | 05/3/2024 |
| Myofibrillar myopathy hallmarks associated with ZAK deficiency. | Myofibrillar myopathy hallmarks associated with ZAK deficiency.
Stonadge A, Genzor AV, Russell A, Hamed MF, Romero N, Evans G, Pownall ME, Bekker-Jensen S, Blanco G., Free PMC Article | 08/30/2023 |
| ZAKalpha-driven ribotoxic stress response activates the human NLRP1 inflammasome. | ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.
Robinson KS, Toh GA, Rozario P, Chua R, Bauernfried S, Sun Z, Firdaus MJ, Bayat S, Nadkarni R, Poh ZS, Tham KC, Harapas CR, Lim CK, Chu W, Tay CWS, Tan KY, Zhao T, Bonnard C, Sobota R, Connolly JE, Common J, Masters SL, Chen KW, Ho L, Wu B, Hornung V, Zhong FL., Free PMC Article | 08/6/2022 |
| ZAK Gene Expression in Patients with Helicobacter pylori Infection. | ZAK Gene Expression in Patients with Helicobacter pylori Infection.
Khani D, Hedayati MA, Nasseri S, Sheikhesmaeili F, Ghadiany R. | 06/18/2022 |
| Targeted inhibition of ZAK ameliorates renal interstitial fibrosis. | Targeted inhibition of ZAK ameliorates renal interstitial fibrosis.
Shu S, Liu H, Yang J, Tang H, Li H, Liu Z, Zhou M, Zhu F, Hu Z, Ding K, Lu X, Nie J. | 06/18/2022 |
| Selective Activation of ZAK beta Expression by 3-Hydroxy-2-Phenylchromone Inhibits Human Osteosarcoma Cells and Triggers Apoptosis via JNK Activation. | Selective Activation of ZAK β Expression by 3-Hydroxy-2-Phenylchromone Inhibits Human Osteosarcoma Cells and Triggers Apoptosis via JNK Activation.
Fu CY, Lay IS, Shibu MA, Tseng YS, Kuo WW, Yang JJ, Wang TF, Bharath BM, Yeh YL, Huang CY., Free PMC Article | 02/20/2021 |
| MicroRNA-335 inhibits the growth, chemo-sensitivity, and metastasis of human breast cancer cells by targeting MAP3K2. | MicroRNA-335 inhibits the growth, chemo-sensitivity, and metastasis of human breast cancer cells by targeting MAP3K2.
Wang Y, Wen F. | 01/23/2021 |
| miR-302a inhibits human HepG2 and SMMC-7721 cells proliferation and promotes apoptosis by targeting MAP3K2 and PBX3. | miR-302a inhibits human HepG2 and SMMC-7721 cells proliferation and promotes apoptosis by targeting MAP3K2 and PBX3.
Wang M, Lv G, Jiang C, Xie S, Wang G., Free PMC Article | 10/3/2020 |
| promoting epithelial mesenchymal transition is the primary role for ZAK in cancer progression. | Mixed lineage kinase ZAK promotes epithelial-mesenchymal transition in cancer progression.
Li L, Su N, Zhou T, Zheng D, Wang Z, Chen H, Yuan S, Li W., Free PMC Article | 08/3/2019 |
| MLK7AS1 has potential as a biomarker and may promote proliferation in CRC partially through downregulating p21 expression. | Long non‑coding RNA MLK7‑AS1 promotes proliferation in human colorectal cancer via downregulation of p21 expression.
Zhang R, Li J, Yan X, Jin K, Li W, Liu X, Zhao J, Shang W, Zhao X. | 06/1/2019 |
| The ZAK rs3769201 and rs722864 may be functional susceptibility loci for lung cancer risk. | Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer.
Feng Y, Wang Y, Liu H, Liu Z, Mills C, Owzar K, Xie J, Han Y, Qian DC, Hung Rj RJ, Brhane Y, McLaughlin J, Brennan P, Bickeböller H, Rosenberger A, Houlston RS, Caporaso N, Landi MT, Brüske I, Risch A, Ye Y, Wu X, Christiani DC, Amos CI, Wei Q., Free PMC Article | 11/24/2018 |
| The expression of ZAKbeta is dependent on ZAKalpha expression, and ZAKbeta further enhances ZAKalpha expression and results in synergistic enhancement of apoptosis in osteosarcoma cells. | Overexpression of ZAKβ in human osteosarcoma cells enhances ZAKα expression, resulting in a synergistic apoptotic effect.
Fu CY, Tseng YS, Chen MC, Hsu HH, Yang JJ, Tu CC, Lin YM, Viswanadha VP, Ding K, Kuo WW, Huang CY. | 07/14/2018 |
| Gene set enrichment analysis disclosed a significant correlation between ZAK+ colorectal premalignant lesions and gene sets belonging to the MAPK/ERK and motility-related signaling pathways of the reactome database, strongly suggesting that ZAK induces such pro-tumoral reaction cascades in human cancers. | The MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer.
Rey C, Faustin B, Mahouche I, Ruggieri R, Brulard C, Ichas F, Soubeyran I, Lartigue L, De Giorgi F. | 09/23/2017 |
| Recessive mutations in the kinase ZAK - novel cause of congenital myopathy. | Recessive mutations in the kinase ZAK cause a congenital myopathy with fibre type disproportion.
Vasli N, Harris E, Karamchandani J, Bareke E, Majewski J, Romero NB, Stojkovic T, Barresi R, Tasfaout H, Charlton R, Malfatti E, Bohm J, Marini-Bettolo C, Choquet K, Dicaire MJ, Shao YH, Topf A, O'Ferrall E, Eymard B, Straub V, Blanco G, Lochmüller H, Brais B, Laporte J, Tétreault M., Free PMC Article | 06/10/2017 |
| ZAK is a key player in mammalian limb patterning in humans and mice. | Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice.
Spielmann M, Kakar N, Tayebi N, Leettola C, Nürnberg G, Sowada N, Lupiáñez DG, Harabula I, Flöttmann R, Horn D, Chan WL, Wittler L, Yilmaz R, Altmüller J, Thiele H, van Bokhoven H, Schwartz CE, Nürnberg P, Bowie JU, Ahmad J, Kubisch C, Mundlos S, Borck G., Free PMC Article | 10/22/2016 |
| ZAK kinase isoform TV1 is preferentially upregulated in gastric tumours and cell lines relative to normal samples. This pattern is also observed in colorectal, bladder and breast cancers. | Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Liu J, McCleland M, Stawiski EW, Gnad F, Mayba O, Haverty PM, Durinck S, Chen YJ, Klijn C, Jhunjhunwala S, Lawrence M, Liu H, Wan Y, Chopra V, Yaylaoglu MB, Yuan W, Ha C, Gilbert HN, Reeder J, Pau G, Stinson J, Stern HM, Manning G, Wu TD, Neve RM, de Sauvage FJ, Modrusan Z, Seshagiri S, Firestein R, Zhang Z., Free PMC Article | 08/8/2015 |
| The long non-coding RNA URHC promotes cell proliferation and inhibits apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK pathway. | Long non-coding RNA URHC regulates cell proliferation and apoptosis via ZAK through the ERK/MAPK signaling pathway in hepatocellular carcinoma.
Xu WH, Zhang JB, Dang Z, Li X, Zhou T, Liu J, Wang DS, Song WJ, Dou KF., Free PMC Article | 04/4/2015 |
| we report that sorafenib suppresses UV-induced apoptosis specifically by inhibiting c-jun-NH(2)-kinase (JNK) activation through the off-target inhibition of leucine zipper and sterile alpha motif-containing kinase (ZAK) | Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK.
Vin H, Ching G, Ojeda SS, Adelmann CH, Chitsazzadeh V, Dwyer DW, Ma H, Ehrenreiter K, Baccarini M, Ruggieri R, Curry JL, Ciurea AM, Duvic M, Busaidy NL, Tannir NM, Tsai KY., Free PMC Article | 10/4/2014 |
| MRK is a novel RhoC effector that controls LPA-stimulated cell invasion at least in part by regulating myosin dynamics, ERK and p38 | The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion.
Korkina O, Dong Z, Marullo A, Warshaw G, Symons M, Ruggieri R., Free PMC Article | 04/27/2013 |
| The genes identified KTN1, ROCK1, and ZAK may be responsible for loss of cellular homeostasis in giant cells tumors of bone | Differentially expressed genes in giant cell tumor of bone.
Babeto E, Conceição AL, Valsechi MC, Peitl Junior P, de Campos Zuccari DA, de Lima LG, Bonilha JL, de Freitas Calmon M, Cordeiro JA, Rahal P. | 05/21/2011 |
| decrease of lung cancer cell proliferation by ZAK may involve the ERK and JNK pathways via an AP-1 transcription factor. | ZAK inhibits human lung cancer cell growth via ERK and JNK activation in an AP-1-dependent manner.
Yang JJ, Lee YJ, Hung HH, Tseng WP, Tu CC, Lee H, Wu WJ., Free PMC Article | 09/20/2010 |
| In this study, by applying a novel method, we have identified the phosphorylation sites in human MSK1 mitogen- and stress-activated protein kinase 1, and show that MRK-beta could also activate MSK1 through direct interaction. | Mapping of phosphorylation sites in human MSK1 activated by a novel interaction with MRK-beta.
Wang W, Han G, Ye M, Shi H, Zou H, Huo K. | 08/2/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| data demonstrate that a ZAK isoform(s) is the MAP3Kinase that transduces the ribotoxic stress response | ZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expression.
Jandhyala DM, Ahluwalia A, Obrig T, Thorpe CM. | 01/21/2010 |
| ZAK induces characteristic hypertrophic growth features, including increased cell size, elevated atrial natriuretic factor expression, and increased actin fiber organization | ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells.
Huang CY, Chueh PJ, Tseng CT, Liu KY, Tsai HY, Kuo WW, Chou MY, Yang JJ. | 01/21/2010 |