| Plasma proenkephalin A and incident chronic kidney disease and albuminuria in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort. | Plasma proenkephalin A and incident chronic kidney disease and albuminuria in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort.
Bullen AL, Katz R, Poursadrolah S, Short SAP, Long DL, Cheung KL, Sharma S, Al-Rousan T, Fregoso A, Schulte J, Gutierrez OM, Shlipak MG, Cushman M, Ix JH, Rifkin DE., Free PMC Article | 01/16/2024 |
| Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis. | Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis.
Lin LC, Chuan MH, Liu JH, Liao HW, Ng LL, Magnusson M, Jujic A, Pan HC, Wu VC, Forni LG., Free PMC Article | 12/18/2023 |
| PENK inhibits osteosarcoma cell migration by activating the PI3K/Akt signaling pathway. | PENK inhibits osteosarcoma cell migration by activating the PI3K/Akt signaling pathway.
Zhang HP, Yu ZL, Wu BB, Sun FR., Free PMC Article | 03/13/2021 |
| PENK-A was neither independently associated with functional outcome (OR: 1.29, 95% CI: 0.16-10.35) nor mortality | Proenkephalin A Adds No Incremental Prognostic Value After Acute Ischemic Stroke.
Gruber P, Fluri F, Schweizer J, Luft A, Müller B, Christ-Crain M, Katan M., Free PMC Article | 07/25/2020 |
| The opioid system, reflected by PENK (proenkephalin), is not only independently associated with glomerular dysfunction, but also with tubular damage in heart failure. | Proenkephalin, an Opioid System Surrogate, as a Novel Comprehensive Renal Marker in Heart Failure.
Emmens JE, Ter Maaten JM, Damman K, van Veldhuisen DJ, de Boer RA, Struck J, Bergmann A, Sama IE, Streng KW, Anker SD, Dickstein K, Lang CC, Metra M, Samani NJ, Ng LL, Voors AA. | 03/14/2020 |
| High PENK is associated with increased risk of CKD defined by eGFR in men, but not in women. No association of PENK with CKD defined by urinary albumin excretion UAE was observed. | Proenkephalin and risk of developing chronic kidney disease: the Prevention of Renal and Vascular End-stage Disease study.
Kieneker LM, Hartmann O, Bergmann A, de Boer RA, Gansevoort RT, Joosten MM, Struck J, Bakker SJL. | 09/29/2018 |
| These results demonstrate that proinflammatory molecules and endogenous enkephalin have opposite gene regulation during Dry eye disease. | Proinflammatory Markers, Chemokines, and Enkephalin in Patients Suffering from Dry Eye Disease.
Nicolle P, Liang H, Reboussin E, Rabut G, Warcoin E, Brignole-Baudouin F, Melik-Parsadaniantz S, Baudouin C, Labbe A, Reaux-Le Goazigo A., Free PMC Article | 09/22/2018 |
| These data indicate that in untrained women exercise training will not change resting of plasma Peptide F concentrations unless both forms of exercise are performed but will result in significant increases in the immediate post-exercise responses. | The effects of different exercise training modalities on plasma proenkephalin Peptide F in women.
DuPont WH, Kraemer WJ, Nindl BC, Lee EC, Fragala MS, Hatfield DL, Caldwell LK, Post EM, Beeler MK, Volek JS, Maresh CM. | 02/24/2018 |
| The concentration of PENK 143-183 was significantly greater in patients with Moyamoya disease (MMD) than control patients and decreased in an age-dependent manner in MMD. | Elevation of Proenkephalin 143-183 in Cerebrospinal Fluid in Moyamoya Disease.
Yokoyama K, Maruwaka M, Yoshikawa K, Araki Y, Okamoto S, Sumitomo M, Kawamura A, Sakamoto Y, Shimizu K, Izumi T, Wakabayashi T. | 12/30/2017 |
| Peptide F is bound to white blood cells in the blood. Exercise alters Peptide F in the plasma and white blood cell blood fractions. | Responses of proenkephalin Peptide F to aerobic exercise stress in the plasma and white blood cell biocompartments.
Kraemer WJ, Fragala MS, van Henegouwen WR, Gordon SE, Bush JA, Volek JS, Triplett NT, Dunn-Lewis C, Comstock BA, Szivak TK, Flanagan SD, Hooper DR, Luk HY, Mastro AM. | 08/4/2016 |
| Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk mRNA and met-enkephalin protein in sensory neurons. | Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7.
Minett MS, Pereira V, Sikandar S, Matsuyama A, Lolignier S, Kanellopoulos AH, Mancini F, Iannetti GD, Bogdanov YD, Santana-Varela S, Millet Q, Baskozos G, MacAllister R, Cox JJ, Zhao J, Wood JN., Free PMC Article | 07/2/2016 |
| The PENK polymorphism-and potentially opioid neurotransmission more generally-modulates functioning and structural integrity of brain regions. | Effects of an opioid (proenkephalin) polymorphism on neural response to errors in health and cocaine use disorder.
Moeller SJ, Beebe-Wang N, Schneider KE, Konova AB, Parvaz MA, Alia-Klein N, Hurd YL, Goldstein RZ., Free PMC Article | 06/4/2016 |
| Serum PENK-A levels were not associated with all-cause mortality in patients with type 2 diabetes mellitus, and its association with cardiovascular mortality was strongly attenuated after accounting for all traditional risk factors. | Serum Proenkephalin A Levels and Mortality After Long-Term Follow-Up in Patients with Type 2 Diabetes Mellitus (ZODIAC-32).
van Hateren KJ, Landman GW, Arnold JF, Joosten H, Groenier KH, Navis GJ, Sparwasser A, Bakker SJ, Bilo HJ, Kleefstra N., Free PMC Article | 05/7/2016 |
| BSP demonstrated that emodin, to a certain degree, affected the demethylation of tumor-suppressor genes P16, RASSF1A, and ppENK in the pancreatic cancer cell line PANC-1. | Effects of emodin on the demethylation of tumor-suppressor genes in pancreatic cancer PANC-1 cells.
Zhang H, Chen L, Bu HQ, Yu QJ, Jiang DD, Pan FP, Wang Y, Liu DL, Lin SZ. | 02/6/2016 |
| enhanced plasma proenkephalin A could be a useful, complementary tool to predict short- or long-term clinical outcome after severe traumatic brain injury. | Prognostic value of neuropeptide proenkephalin A in patients with severe traumatic brain injury.
Gao JB, Tang WD, Wang X, Shen J. | 04/4/2015 |
| increased plasma PENK-A levels are associated with disease severity and in-hospital mortality after acute intracerebral hemorrhage. | Neuropeptide proenkephalin A is associated with in-hospital mortality in patients with acute intracerebral hemorrhage.
Yang XG, An HL, Zhang JM. | 04/4/2015 |
| EPS led to the discovery of two novel immunomodulatory proteins, MFAP5 and PENK that when administered to mice subjected to endotoxemic shock, reversed the cytokine storm and provided a significant survival benefit | Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators.
Milwid JM, Elman JS, Li M, Shen K, Manrai A, Gabow A, Yarmush J, Jiao Y, Fletcher A, Lee J, Cima MJ, Yarmush ML, Parekkadan B., Free PMC Article | 02/28/2015 |
| Data from women undergoing hysterectomy for uterine fibroids suggest that uterine isthmian-cervical region exhibits nerve fibers expressing enkephalin (ENK); uterine fundus/corpus myoma pseudocapsules do not exhibit nerve fibers expressing ENK. | The opioid neuropeptides in uterine fibroid pseudocapsules: a putative association with cervical integrity in human reproduction.
Malvasi A, Cavallotti C, Nicolardi G, Pellegrino M, Vergara D, Greco M, Kosmas I, Mynbaev OA, Kumakiri J, Tinelli A. | 05/10/2014 |
| Promoter methylation of WIF1, PENK and NPY is associated with colorectal adenocarcinoma (CRC) diagnosis and can be used to CRC from other cancers. | Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer.
Roperch JP, Incitti R, Forbin S, Bard F, Mansour H, Mesli F, Baumgaertner I, Brunetti F, Sobhani I., Free PMC Article | 03/22/2014 |
| Expression of preproenkephalin is significantly decreased in brain from HIV-1 infected patients compared to HIV-1 negative subjects. | Prefrontal dopaminergic and enkephalinergic synaptic accommodation in HIV-associated neurocognitive disorders and encephalitis.
Gelman BB, Lisinicchia JG, Chen T, Johnson KM, Jennings K, Freeman DH Jr, Soukup VM., Free PMC Article | 04/13/2013 |
| The findings suggest an important role for Neuroticism as an endophenotype linking PENK polymorphisms to cannabis-dependence vulnerability synergistically amplifying the apparent genetic risk. | Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study.
Jutras-Aswad D, Jacobs MM, Yiannoulos G, Roussos P, Bitsios P, Nomura Y, Liu X, Hurd YL., Free PMC Article | 12/8/2012 |
| found higher levels for MOR mRNA (+27%) in schizophrenia but no differences in DOR or proenkephalin mRNAs | Cortical opioid markers in schizophrenia and across postnatal development.
Volk DW, Radchenkova PV, Walker EM, Sengupta EJ, Lewis DA., Free PMC Article | 08/11/2012 |
| Findings indicate the unique function of cathepsin V for producing enkephalin and neuropeptide Y (NPY) neuropeptides required for neurotransmission in health and neurological diseases. | Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters.
Funkelstein L, Lu WD, Koch B, Mosier C, Toneff T, Taupenot L, O'Connor DT, Reinheckel T, Peters C, Hook V., Free PMC Article | 08/4/2012 |
| Differential tertiary conformations of PE subdomains undergo ordered proteolytic processing to generate active enkephalin peptides for cell-cell communication in the nervous and endocrine systems. | The prohormone proenkephalin possesses differential conformational features of subdomains revealed by rapid H-D exchange mass spectrometry.
Lu WD, Liu T, Li S, Woods VL Jr, Hook V., Free PMC Article | 06/2/2012 |
| we demonstrated reduced ppE expression in patients with elevated psychological distress. | Preproenkephalin expression in peripheral blood mononuclear cells of acutely underweight and recovered patients with anorexia nervosa.
Weiss D, Infante-Duarte C, Salbach-Andrae H, Burghardt R, Hamann I, Pfeiffer E, Lehmkuhl U, Ehrlich S. | 11/27/2010 |