| Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency. | Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency.
Sweatt AJ, Miyagawa K, Rhodes CJ, Taylor S, Del Rosario PA, Hsi A, Haddad F, Spiekerkoetter E, Bental-Roof M, Bland RD, Swietlik EM, Gräf S, Wilkins MR, Morrell NW, Nicolls MR, Rabinovitch M, Zamanian RT., Free PMC Article | 01/15/2022 |
| Upregulation of elafin expression in the fallopian tube of ectopic tubal pregnancies compared to the normal tubes. | Upregulation of elafin expression in the fallopian tube of ectopic tubal pregnancies compared to the normal tubes.
Zakizadeh F, Mahmoudzadeh-Sagheb H, Asemi-Rad A, Ghasemi M, Moudi B, Sheibak N, Asadikalameh Z, Heidari Z. | 09/25/2021 |
| Recombinant Human Elafin Ameliorates Chronic Hyperoxia-Induced Lung Injury by Inhibiting Nuclear Factor-Kappa B Signaling in Neonatal Mice. | Recombinant Human Elafin Ameliorates Chronic Hyperoxia-Induced Lung Injury by Inhibiting Nuclear Factor-Kappa B Signaling in Neonatal Mice.
Li K, Zhang F, Wei L, Han Z, Liu X, Pan Y, Guo C, Han W. | 07/17/2021 |
| Elafin as a Predictive Biomarker of Acute Skin Graft-Versus-Host Disease After Haploidentical Stem Cell Transplantation Using Post-Transplant High-Dose Cyclophosphamide. | Elafin as a Predictive Biomarker of Acute Skin Graft-Versus-Host Disease After Haploidentical Stem Cell Transplantation Using Post-Transplant High-Dose Cyclophosphamide.
Solán L, Carbonell D, Muñiz P, Dorado N, Landete E, Chicano-Lavilla M, Anguita J, Gayoso J, Kwon M, Díez-Martín JL, Martínez-Laperche C, Buño I., Free PMC Article | 07/3/2021 |
| Evaluation of Elafin Immunohistochemical Expression as Marker of Cervical Cancer Severity. | Evaluation of Elafin Immunohistochemical Expression as Marker of Cervical Cancer Severity.
Longatto-Filho A, Fregnani JH, Mafra da Costa A, de Araujo-Souza PS, Scapulatempo-Neto C, Herbster S, Boccardo E, Termini L. | 04/3/2021 |
| Metabolic Syndrome, Clusterin and Elafin in Patients with Psoriasis Vulgaris. | Metabolic Syndrome, Clusterin and Elafin in Patients with Psoriasis Vulgaris.
Holmannova D, Borsky P, Borska L, Andrys C, Hamakova K, Rehacek V, Svadlakova T, Malkova A, Beranek M, Palicka V, Krejsek J, Fiala Z., Free PMC Article | 02/20/2021 |
| High circulating elafin levels are associated with the presence of stricture in Crohn's disease (CD) patients. Serum elafin levels may help identify intestinal strictures in CD patients. | High circulating elafin levels are associated with Crohn's disease-associated intestinal strictures.
Wang J, Ortiz C, Fontenot L, Xie Y, Ho W, Mattai SA, Shih DQ, Koon HW., Free PMC Article | 07/18/2020 |
| A positive association between the psoriasis area and severity index score with three serum proteins (PI3, CCL22, IL-12B) has been found. | In-depth serum proteomics reveals biomarkers of psoriasis severity and response to traditional Chinese medicine.
Xu M, Deng J, Xu K, Zhu T, Han L, Yan Y, Yao D, Deng H, Wang D, Sun Y, Chang C, Zhang X, Dai J, Yue L, Zhang Q, Cai X, Zhu Y, Duan H, Liu Y, Li D, Zhu Y, Radstake TRDJ, Balak DMW, Xu D, Guo T, Lu C, Yu X., Free PMC Article | 06/27/2020 |
| Endothelial trappin-2 up-regulation partially due to Fli1 deficiency can be associated with the development of SSc vasculopathy. | A potential contribution of trappin-2 to the development of vasculopathy in systemic sclerosis.
Miyagawa T, Asano Y, Saigusa R, Hirabayashi M, Yamashita T, Taniguchi T, Takahashi T, Nakamura K, Miura S, Yoshizaki A, Miyagaki T, Sato S. | 08/10/2019 |
| Elafin decreased in active patients with inflammatory bowel disease and was negatively correlated with disease activity, suggesting that elafin may play a protective role | Expression and Clinical Significance of Elafin in Inflammatory Bowel Disease.
Zhang W, Teng G, Wu T, Tian Y, Wang H. | 07/21/2018 |
| Plasma Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome | Plasma Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome: A Multicenter Survival and Longitudinal Prospective Observation Study.
Wang T, Zhu Z, Liu Z, Yi L, Yang Z, Bian W, Chen W, Wang S, Li G, Li A, Martin GS, Zhu X. | 04/14/2018 |
| UV phototoxicity-induced pre-elafin inside keratinocytes prior to cornified envelope formation could be involved in UV-induced keratinocyte apoptosis via cystatin-A downregulation resulting in pro-caspase-3 activation. | Pre-elafin is Involved in Ultraviolet-induced Keratinocyte Apoptosis via Pro-caspase-3 Activation Associated with Cystatin-A Down-regulation.
Kim H, Noh M, Bae ON, Lee CH, Lee AY. | 03/10/2018 |
| Recombinant human elafin promotes alveologenesis in newborn mice exposed to chronic hyperoxia | Recombinant human elafin promotes alveologenesis in newborn mice exposed to chronic hyperoxia.
Han W, Li X, Zhang H, Yu B, Guo C, Deng C. | 12/2/2017 |
| significantly higher expression in preterm prelabor ruptured fetal membranes than in membranes from term birth | Anti-inflammatory Elafin in human fetal membranes.
Stalberg C, Noda N, Polettini J, Jacobsson B, Menon R. | 07/15/2017 |
| Our study revealed that high elafin levels identified in smoking- and asthma-related microarray data sets and an epidemiologic study significantly reduced the risk of asthma. | Protective effects of elafin against adult asthma.
Tsai YS, Tseng YT, Chen PS, Lin MC, Wu CC, Huang MS, Wang CC, Chen KS, Lin YC, Wang TN. | 12/17/2016 |
| The expression of elafin in fallopian tubes of ectopic pregnancies is reduced. | Expression of elafin in fallopian tubes of ectopic pregnancies is reduced.
Grudzinski M, Fuhrich DG, Savaris RF. | 02/13/2016 |
| The elevations in cervical elafin and SLPI expression in the women with preterm delivery might reflect the local response to the pathogen invasion into the cervix preceding preterm labor. | Cervical Expression of Elafin and SLPI in Pregnancy and Their Association With Preterm Labor.
Itaoka N, Nagamatsu T, Schust DJ, Ichikawa M, Sayama S, Iwasawa-Kawai Y, Kawana K, Yamashita T, Osuga Y, Fujii T. | 02/13/2016 |
| PI3 expression was downregulated in 24% of DCIS and 83% of invasive breast tumors. PI3 was also downregulated in 33% of ovarian cystadenomas, 43% of borderline ovarian tumors, and 86% of invasive ovarian carcinomas. | Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence.
Caruso JA, Karakas C, Zhang J, Yi M, Albarracin C, Sahin A, Bondy M, Liu J, Hunt KK, Keyomarsi K., Free PMC Article | 11/14/2015 |
| The imbalance between neutrophil elastase and its inhibitors, such as elafin, presents an important therapeutic target in breast cancer. | The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase.
Caruso JA, Akli S, Pageon L, Hunt KK, Keyomarsi K., Free PMC Article | 10/3/2015 |
| Higher urinary elafin levels are associated with an increased risk of micro- and macroalbuminuria, acute kidney injury and chronic kidney disease, and death after hematopoietic stem cell transplantation. | Urinary elafin and kidney injury in hematopoietic cell transplant recipients.
Hingorani S, Finn LS, Pao E, Lawler R, Schoch G, McDonald GB, Najafian B, Sandmaier B, Gooley T., Free PMC Article | 09/12/2015 |
| cutaneous elafin does not seem to discriminate acute graft-versus-host disease from drug hypersensitivity rash lesions, but there may be an association between cutaneous elafin expression and poor prognosis for patients with cutaneous GVHD | Epidermal elafin expression is an indicator of poor prognosis in cutaneous graft-versus-host disease.
Brüggen MC, Petzelbauer P, Greinix H, Contassot E, Jankovic D, French L, Socié G, Rabitsch W, Kuzmina Z, Kalhs P, Knobler R, Stingl G, Stary G. | 05/30/2015 |
| Data indicate that elafin overexpression is associated with poor overall survival. | Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors.
Labidi-Galy SI, Clauss A, Ng V, Duraisamy S, Elias KM, Piao HY, Bilal E, Davidowitz RA, Lu Y, Badalian-Very G, Györffy B, Kang UB, Ficarro S, Ganesan S, Mills GB, Marto JA, Drapkin R., Free PMC Article | 04/25/2015 |
| Low expression of elafin gene correlated with significantly reduced time to relapse, and when combined with high expression of elastase gene was associated with decreased survival in breast cancer patients | Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer.
Hunt KK, Wingate H, Yokota T, Liu Y, Mills GB, Zhang F, Fang B, Su CH, Zhang M, Yi M, Keyomarsi K., Free PMC Article | 03/21/2015 |
| Elafin has important roles in normal homoeostasis and at sites of inflammation. These roles include antiprotease and antimicrobial activity. | Human gammadelta T cells produce the protease inhibitor and antimicrobial peptide elafin.
Marischen L, Wesch D, Schröder JM, Wiedow O, Kabelitz D. | 11/6/2014 |
| Results confirm the association between SNP rs2664581 and enhanced risk of developing acute respiratory distress syndrome. | Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome.
Tejera P, O'Mahony DS, Owen CA, Wei Y, Wang Z, Gupta K, Su L, Villar J, Wurfel M, Christiani DC., Free PMC Article | 10/4/2014 |