| PITX2 functions as a transcription factor for GPX4 and protects pancreatic cancer cells from ferroptosis. | PITX2 functions as a transcription factor for GPX4 and protects pancreatic cancer cells from ferroptosis.
Wang Z, Wu D, Zhang Y, Chen W, Yang Y, Yang Y, Zu G, An Y, Yu X, Qin Y, Xu X, Chen X. | 06/13/2024 |
| Intergenic sequences harboring potential enhancer elements contribute to Axenfeld-Rieger syndrome by regulating PITX2. | Intergenic sequences harboring potential enhancer elements contribute to Axenfeld-Rieger syndrome by regulating PITX2.
Jiang Y, Peng Y, Tian Q, Cheng Z, Feng B, Hu J, Xia L, Guo H, Xia K, Zhou L, Hu Z., Free PMC Article | 05/10/2024 |
| Exploring the association between PITX2, third molars agenesis and sella turcica morphology : PITX2, third molars agenesis and sella turcica morphology. | Exploring the association between PITX2, third molars agenesis and sella turcica morphology : PITX2, third molars agenesis and sella turcica morphology.
Küchler EC, de Melo Teixeira do Brasil J, Madalena IR, Proff P, Baratto-Filho F, Alam MK, Schroder AGD, Lepri CP, Kirschneck C, de Menezes-Oliveira MAH., Free PMC Article | 03/4/2024 |
| Enamel defects of Axenfeld-Rieger syndrome and the role of PITX2 in its pathogenesis. | Enamel defects of Axenfeld-Rieger syndrome and the role of PITX2 in its pathogenesis.
Yang Y, Zhu J, Chiba Y, Fukumoto S, Qin M, Wang X. | 12/15/2023 |
| Pulmonary Vein Myocardial Sleeve Length and its Association With Sex and 4q25/PITX2 Genotype. | Pulmonary Vein Myocardial Sleeve Length and its Association With Sex and 4q25/PITX2 Genotype.
El-Harasis MA, Yoneda ZT, Davogustto GE, Crawford DM, Laws JL, Frye B, Herrmann T, Patel B, Touchton SA Jr, Roden DM, Richardson TD, Saavedra P, Shen ST, Estrada JC, Kanagasundram AN, Montgomery JA, Michaud GF, Crossley GH, Ellis CR, Shoemaker MB. | 07/31/2023 |
| PITX2 Knockout Induces Key Findings of Electrical Remodeling as Seen in Persistent Atrial Fibrillation. | PITX2 Knockout Induces Key Findings of Electrical Remodeling as Seen in Persistent Atrial Fibrillation.
Schulz C, Lemoine MD, Mearini G, Koivumäki J, Sani J, Schwedhelm E, Kirchhof P, Ghalawinji A, Stoll M, Hansen A, Eschenhagen T, Christ T. | 03/27/2023 |
| PITX2 induction leads to impaired cardiomyocyte function in arrhythmogenic cardiomyopathy. | PITX2 induction leads to impaired cardiomyocyte function in arrhythmogenic cardiomyopathy.
van Kampen SJ, Han SJ, van Ham WB, Kyriakopoulou E, Stouthart EW, Goversen B, Monshouwer-Kloots J, Perini I, de Ruiter H, van der Kraak P, Vink A, van Laake LW, Groeneweg JA, de Boer TP, Tsui H, Boogerd CJ, van Veen TAB, van Rooij E., Free PMC Article | 03/22/2023 |
| Association Between rs2200733 Polymorphism of PITX2 Gene and the Risk of Atrial Fibrillation. | Association Between rs2200733 Polymorphism of PITX2 Gene and the Risk of Atrial Fibrillation.
Shen Han Y, Ahmed AM, Chao Z, Jun W, Xiaochen Y., Free PMC Article | 03/6/2023 |
| Genotype-phenotype association of PITX2 and FOXC1 in Axenfeld-Rieger syndrome. | Genotype-phenotype association of PITX2 and FOXC1 in Axenfeld-Rieger syndrome.
Zhou L, Wang X, An J, Zhang Y, He M, Tang L. | 01/21/2023 |
| Comparison of Anterior Segment Abnormalities in Individuals With FOXC1 and PITX2 Variants. | Comparison of Anterior Segment Abnormalities in Individuals With FOXC1 and PITX2 Variants.
Prem Senthil M, Knight LSW, Taranath D, Mackey DA, Ruddle JB, Chiang MY, Siggs OM, Souzeau E, Craig JE., Free PMC Article | 07/23/2022 |
| Decoding the PITX2-controlled genetic network in atrial fibrillation. | Decoding the PITX2-controlled genetic network in atrial fibrillation.
Steimle JD, Grisanti Canozo FJ, Park M, Kadow ZA, Samee MAH, Martin JF., Free PMC Article | 06/18/2022 |
| Effect of PITX2 genetic variants on the susceptibility to stroke in the Chinese Han population. | Effect of PITX2 genetic variants on the susceptibility to stroke in the Chinese Han population.
Zhao W, Hu X, Hao J, Guo L, Zhang W, Liu J, Jin T, Gao D, Zhi J. | 05/14/2022 |
| Long noncoding RNA PCAT1 sponges miR1343p to regulate PITX2 expression in breast cancer. | Long non‑coding RNA PCAT1 sponges miR‑134‑3p to regulate PITX2 expression in breast cancer.
Tang W, Lu G, Ji Y, Xu Y. | 04/2/2022 |
| Genome-wide association study-based prediction of atrial fibrillation using artificial intelligence. | Genome-wide association study-based prediction of atrial fibrillation using artificial intelligence.
Kwon OS, Hong M, Kim TH, Hwang I, Shim J, Choi EK, Lim HE, Yu HT, Uhm JS, Joung B, Oh S, Lee MH, Kim YH, Pak HN., Free PMC Article | 03/12/2022 |
| Paired-like homeodomain transcription factor 2 affects endometrial cell function and embryo implantation through the Wnt/beta-catenin pathway. | Paired-like homeodomain transcription factor 2 affects endometrial cell function and embryo implantation through the Wnt/β-catenin pathway.
Zhang H, Qi J, Guo J, Wang Y, Guan Y, Fan J, Sui L, Xu Y, Kong L, Yan B, Kong Y. | 01/15/2022 |
| In Silico Assessment of Class I Antiarrhythmic Drug Effects on Pitx2-Induced Atrial Fibrillation: Insights from Populations of Electrophysiological Models of Human Atrial Cells and Tissues. | In Silico Assessment of Class I Antiarrhythmic Drug Effects on Pitx2-Induced Atrial Fibrillation: Insights from Populations of Electrophysiological Models of Human Atrial Cells and Tissues.
Bai J, Zhu Y, Lo A, Gao M, Lu Y, Zhao J, Zhang H., Free PMC Article | 09/11/2021 |
| Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models. | Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models.
Bai J, Lu Y, Zhu Y, Wang H, Yin D, Zhang H, Franco D, Zhao J., Free PMC Article | 08/7/2021 |
| Gene-specific facial dysmorphism in Axenfeld-Rieger syndrome caused by FOXC1 and PITX2 variants. | Gene-specific facial dysmorphism in Axenfeld-Rieger syndrome caused by FOXC1 and PITX2 variants.
Souzeau E, Siggs OM, Pasutto F, Knight LSW, Perez-Jurado LA, McGregor L, Le Blanc S, Barnett CP, Liebelt J, Craig JE., Free PMC Article | 07/10/2021 |
| Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma. | Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma.
Cai J, Drewry MD, Perkumas K, Dismuke WM, Hauser MA, Stamer WD, Liu Y., Free PMC Article | 07/3/2021 |
| A PITX2 splice-site mutation in a family with Axenfeld-Rieger syndrome leads to decreased expression of nuclear PITX2 protein. | A PITX2 splice-site mutation in a family with Axenfeld-Rieger syndrome leads to decreased expression of nuclear PITX2 protein.
Zhang F, Zhang L, He L, Cao M, Yang Y, Duan X, Shi J, Liu K., Free PMC Article | 07/3/2021 |
| Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation. | Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation.
Reyat JS, Chua W, Cardoso VR, Witten A, Kastner PM, Kabir SN, Sinner MF, Wesselink R, Holmes AP, Pavlovic D, Stoll M, Kääb S, Gkoutos GV, de Groot JR, Kirchhof P, Fabritz L., Free PMC Article | 06/12/2021 |
| Novel mutations in the PITX2 gene in Pakistani and Mexican families with Axenfeld-Rieger syndrome. | Novel mutations in the PITX2 gene in Pakistani and Mexican families with Axenfeld-Rieger syndrome.
Lo Faro V, Siddiqui SN, Khan MI, Villanueva-Mendoza C, Cortés-González V, Jansonius N, Bergen AAB, Micheal S., Free PMC Article | 05/1/2021 |
| The diagnosis and phacoemulsification in combination with intraocular lens implantation for an Axenfeld-Rieger syndrome patient with small cornea: a case report. | The diagnosis and phacoemulsification in combination with intraocular lens implantation for an Axenfeld-Rieger syndrome patient with small cornea: a case report.
Ma Y, Wu X, Ni S, Chen X, He S, Xu W., Free PMC Article | 03/6/2021 |
| In Silico Assessment of Genetic Variation in PITX2 Reveals the Molecular Mechanisms of Calcium-Mediated Cellular Triggered Activity in Atrial Fibrillation(.) | In Silico Assessment of Genetic Variation in PITX2 Reveals the Molecular Mechanisms of Calcium-Mediated Cellular Triggered Activity in Atrial Fibrillation().
Bai J, Zhu Y, Lo A, Lu Y, Zhao J. | 10/31/2020 |
| Findings suggest that downregulation of Pitx2c may regulate atrial fibrosis through modulating calcium homeostasis, which may contribute to its role in anti-atrial fibrosis, and Pitx2c downregulation may change the atrial electrophysiology and atrial fibrillation occurrence through modulating fibroblast activity. | Pitx2c inhibition increases atrial fibroblast activity: Implications in atrial arrhythmogenesis.
Kao YH, Chung CC, Cheng WL, Lkhagva B, Chen YJ. | 06/6/2020 |