| Unveiling the Binding between the Armadillo-Repeat Domain of Plakophilin 1 and the Intrinsically Disordered Transcriptional Repressor RYBP. | Unveiling the Binding between the Armadillo-Repeat Domain of Plakophilin 1 and the Intrinsically Disordered Transcriptional Repressor RYBP.
Araujo-Abad S, Rizzuti B, Vidal M, Abian O, Fárez-Vidal ME, Velazquez-Campoy A, de Juan Romero C, Neira JL., Free PMC Article | 09/10/2024 |
| The role of PKP1 in tumor progression in melanoma: Analysis of a cell adhesion-related model. | The role of PKP1 in tumor progression in melanoma: Analysis of a cell adhesion-related model.
Yue C, Lian W, Fan Z, Li H, Duan M, Qin L, Cao X, Peng J. | 01/11/2024 |
| Elucidation of the inhibitory potential of flavonoids against PKP1 protein in non-small cell lung cancer. | Elucidation of the inhibitory potential of flavonoids against PKP1 protein in non-small cell lung cancer.
Pandey P, Khan F, Chauhan P, Upadhyay TK, Bardakci F, Alam MJ, Almuzaini N, Abdalla RAH, Singh SK, Saeed M. | 05/3/2023 |
| Plakophilin 1 deficiency in prostatic tumours is correlated with immune cell recruitment and controls the up-regulation of cytokine expression post-transcriptionally. | Plakophilin 1 deficiency in prostatic tumours is correlated with immune cell recruitment and controls the up-regulation of cytokine expression post-transcriptionally.
Kim M, Reidenbach S, Schlechter T, Rothmann AC, Will R, Hofmann I. | 04/7/2023 |
| The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4. | The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4.
Neira JL, Rizzuti B, Araujo-Abad S, Abian O, Fárez-Vidal ME, Velazquez-Campoy A, de Juan Romero C. | 01/21/2023 |
| PKP1 and MYC create a feedforward loop linking transcription and translation in squamous cell lung cancer. | PKP1 and MYC create a feedforward loop linking transcription and translation in squamous cell lung cancer.
Boyero L, Martin-Padron J, Fárez-Vidal ME, Rodriguez MI, Andrades Á, Peinado P, Arenas AM, Ritoré-Salazar F, Alvarez-Perez JC, Cuadros M, Medina PP. | 05/7/2022 |
| The Prognostic Significance of Plakophilin-1 Expression in Esophageal Cancer. | The Prognostic Significance of Plakophilin-1 Expression in Esophageal Cancer.
Fujita J, Nakajima M, Muroi H, Kikuchi M, Ihara K, Yamaguchi T, Nakagawa M, Morita S, Nakamura T, Tsuchioka T, Kojima K. | 07/10/2021 |
| Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1. | Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1.
Santofimia-Castaño P, Rizzuti B, Pey AL, Fárez-Vidal ME, Iovanna JL, Neira JL. | 04/17/2021 |
| LncRNA APPAT regulated miR-328a/Pkp1 signal pathway to participate in breast cancer. | LncRNA APPAT regulated miR-328a/Pkp1 signal pathway to participate in breast cancer.
Wang WF, Zhao N, Li YQ, Luo MY, Xiao SQ, Yang W. | 04/3/2021 |
| In advanced primary lung tumor samples, higher expression of plakophilin 1 (PKP1) was significantly associated with favorable clinical outcome. | Plakophilin 1 is methylated and has a tumor suppressive activity in human lung cancer.
Haase D, Cui T, Yang L, Ma Y, Liu H, Theis B, Petersen I, Chen Y. | 02/29/2020 |
| 14-3-3gamma associated primarily with cytoplasmic PKP1 phosphorylated at S155 and destabilized intercellular cohesion of keratinocytes by reducing its incorporation into desmosomes. | 14-3-3 proteins regulate desmosomal adhesion via plakophilins.
Rietscher K, Keil R, Jordan A, Hatzfeld M. | 11/2/2019 |
| These results implicate the participation of PKP1 in early tooth morphogenesis as an effector of canonical Wnt signaling that controls ameloblast differentiation via regulation of the cell adhesion complex | Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast Differentiation.
Miyazaki K, Yoshizaki K, Arai C, Yamada A, Saito K, Ishikawa M, Xue H, Funada K, Haruyama N, Yamada Y, Fukumoto S, Takahashi I., Free PMC Article | 08/6/2016 |
| Collectively, altered expression of PKP1 and SPOCK1 appears to be a frequent and critical event in prostate cancer | Plakophilin 1-deficient cells upregulate SPOCK1: implications for prostate cancer progression.
Yang C, Fischer-Kešo R, Schlechter T, Ströbel P, Marx A, Hofmann I. | 04/23/2016 |
| cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein particles and act as posttranscriptional regulators of gene expression. | Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.
Fischer-Kešo R, Breuninger S, Hofmann S, Henn M, Röhrig T, Ströbel P, Stoecklin G, Hofmann I., Free PMC Article | 01/17/2015 |
| Plakophilin-1 has a role in protecting keratinocytes from pemphigus vulgaris IgG by forming calcium-independent desmosomes | Plakophilin-1 protects keratinocytes from pemphigus vulgaris IgG by forming calcium-independent desmosomes.
Tucker DK, Stahley SN, Kowalczyk AP., Free PMC Article | 05/31/2014 |
| Data indicate that upon activation of growth factor signaling, plakophilin 1 switches from a desmosome-associated growth-inhibiting to a cytoplasmic proliferation-promoting function. | Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation.
Wolf A, Rietscher K, Glaß M, Hüttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M. | 11/2/2013 |
| In breast cancer, compared with normal tissue, PKP1 and PKP2 expressions were indifferent (P > 0.05), but PKP3 expression was significantly increased | Expression of Plakophilins (PKP1, PKP2, and PKP3) in breast cancers.
Demirag GG, Sullu Y, Yucel I. | 06/15/2013 |
| PKP1 loss secondary to promoter methylation, as well as other mechanisms, may promote the progression of Barrett's esophagus to esophageal adenocarcinoma in a subset of patients via decreased desmosome assembly and increased cell motility | Aberrantly methylated PKP1 in the progression of Barrett's esophagus to esophageal adenocarcinoma.
Kaz AM, Luo Y, Dzieciatkowski S, Chak A, Willis JE, Upton MP, Leidner RS, Grady WM., Free PMC Article | 06/16/2012 |
| both loss of PKP1 and up-regulation of PKP3 expression are biologically important events in prostate cancer and are associated with a more aggressive phenotype | Desmosomal plakophilins in the prostate and prostatic adenocarcinomas: implications for diagnosis and tumor progression.
Breuninger S, Reidenbach S, Sauer CG, Ströbel P, Pfitzenmaier J, Trojan L, Hofmann I., Free PMC Article | 01/1/2011 |
| in addition to mediating desmosome assembly, the nuclear pool of Pkp can influence cell survival by interactions with DNA | Plakophilin-1 localizes to the nucleus and interacts with single-stranded DNA.
Sobolik-Delmaire T, Reddy R, Pashaj A, Roberts BJ, Wahl JK 3rd. | 11/27/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesMaternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| These findings identify PKP1 as a regulator of translation and proliferation via modulation of eIF4A1 activity. | Plakophilin 1 stimulates translation by promoting eIF4A1 activity.
Wolf A, Krause-Gruszczynska M, Birkenmeier O, Ostareck-Lederer A, Hüttelmaier S, Hatzfeld M., Free PMC Article | 03/29/2010 |
| the clinicopathologic features attest to the significant role of PKP1 in stabilization of desmosome structure and function, predominantly in the spinous layers of the epidermis | Ectodermal dysplasia-skin fragility syndrome.
McGrath JA, Mellerio JE. | 02/22/2010 |