| PLCbeta2 Promotes VEGF-Induced Vascular Permeability. | PLCβ2 Promotes VEGF-Induced Vascular Permeability.
Phoenix KN, Yue Z, Yue L, Cronin CG, Liang BT, Hoeppner LH, Claffey KP., Free PMC Article | 10/8/2022 |
| Knockdown of PLCB2 expression reduces melanoma cell viability and promotes melanoma cell apoptosis by altering Ras/Raf/MAPK signals. | Knockdown of PLCB2 expression reduces melanoma cell viability and promotes melanoma cell apoptosis by altering Ras/Raf/MAPK signals.
Zhang H, Xie T, Shui Y, Qi Y. | 10/31/2020 |
| High PLCB2 expression is associated with breast cancer. | Ectopic expression of PLC-β2 in non-invasive breast tumor cells plays a protective role against malignant progression and is correlated with the deregulation of miR-146a.
Bertagnolo V, Grassilli S, Volinia S, Al-Qassab Y, Brugnoli F, Vezzali F, Lambertini E, Palomba M, Piubello Q, Orvieto E, Natali C, Piva R, Croce CM, Capitani S., Free PMC Article | 07/6/2019 |
| this work adds substantial information about the role of PLC-beta2 in invasive breast tumors, demonstrating that its up-regulation in cells with a basal-B triple-negative phenotype is sufficient to down-modulate the expression of surface antigens crucial for malignancy and to reduce the number of cells with a stem-like phenotype. | Up-modulation of PLC-β2 reduces the number and malignancy of triple-negative breast tumor cells with a CD133(+)/EpCAM(+) phenotype: a promising target for preventing progression of TNBC.
Brugnoli F, Grassilli S, Lanuti P, Marchisio M, Al-Qassab Y, Vezzali F, Capitani S, Bertagnolo V., Free PMC Article | 05/5/2018 |
| Hypoxia modulates the expression of PLC-beta-2 in breast tumor cells in a phenotype-related manner, since a decrease of the protein was observed in the BT-474 and MCF7 cell lines while an increase was revealed in MDA-MB-231 cells as a consequence of low oxygen availability. | PLC-β2 is modulated by low oxygen availability in breast tumor cells and plays a phenotype dependent role in their hypoxia-related malignant potential.
Brugnoli F, Grassilli S, Al-Qassab Y, Capitani S, Bertagnolo V. | 09/9/2017 |
| Gnb isoforms control a signaling pathway comprising Rac1, Plcbeta2, and Plcbeta3 leading to LFA-1 activation and neutrophil arrest in vivo | Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo.
Block H, Stadtmann A, Riad D, Rossaint J, Sohlbach C, Germena G, Wu D, Simon SI, Ley K, Zarbock A., Free PMC Article | 06/11/2016 |
| Neuropeptide Y decreased PLCB2 expression in HUVECs. | Neuropeptide Y reduces the expression of PLCB2, PLCD1 and selected PLC genes in cultured human endothelial cells.
Lo Vasco VR, Leopizzi M, Puggioni C, Della Rocca C, Businaro R. | 10/31/2015 |
| high expression of CD133 in triple-negative breast cancer (TNBC)-derived cells correlates with high invasive potential; aggressive properties of CD133high cells are mitigated by PLC-beta2 which down-modulates expression of CD133 and may play a role in preventing metastatic progression of CD133 positive TNBC | In triple negative breast tumor cells, PLC-β2 promotes the conversion of CD133high to CD133low phenotype and reduces the CD133-related invasiveness.
Brugnoli F, Grassilli S, Piazzi M, Palomba M, Nika E, Bavelloni A, Capitani S, Bertagnolo V., Free PMC Article | 07/19/2014 |
| WDR26 functions as a scaffolding protein to promote PLCbeta2 membrane translocation and interaction with Gbetagamma, thereby enhancing PLCbeta2 activation in leukocytes. | WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes.
Sun Z, Smrcka AV, Chen S., Free PMC Article | 08/31/2013 |
| In this study, we show that staphylococcal enterotoxin B activates a Galphaq and PLCbeta2-dependent pathway in human T cells | Superantigen-induced steroid resistance depends on activation of phospholipase Cβ2.
Verhaar AP, Wildenberg ME, Duijvestein M, Vos AC, Peppelenbosch MP, Löwenberg M, Hommes DW, van den Brink GR. | 08/31/2013 |
| PLCbeta2 is enriched in the cytosol. | PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq.
Adjobo-Hermans MJ, Crosby KC, Putyrski M, Bhageloe A, van Weeren L, Schultz C, Goedhart J, Gadella TW Jr. | 05/4/2013 |
| gamma-synuclein has a role in promoting a more robust G protein Galphaq activation of PLCbeta2 | γ-Synuclein interacts with phospholipase Cβ2 to modulate G protein activation.
Golebiewska U, Guo Y, Khalikaprasad N, Zurawsky C, Yerramilli VS, Scarlata S., Free PMC Article | 02/16/2013 |
| GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. | GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
Suire S, Lécureuil C, Anderson KE, Damoulakis G, Niewczas I, Davidson K, Guillou H, Pan D, Jonathan Clark, Phillip T Hawkins, Stephens L., Free PMC Article | 09/29/2012 |
| WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Galphaq and phospholipase C beta 2 in a signalling complex | WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Gαq and phospholipase Cβ in a signalling complex.
Cartier A, Parent A, Labrecque P, Laroche G, Parent JL. | 01/14/2012 |
| Rac1 activates phospholipase Cdelta1 through phospholipase Cbeta2 | The small G protein Rac1 activates phospholipase Cdelta1 through phospholipase Cbeta2.
Guo Y, Golebiewska U, D'Amico S, Scarlata S., Free PMC Article | 09/27/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesVariation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LAC, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S. | 06/30/2010 |
| Data show that activation of PLCbeta(2) by alpha(q) and beta1gamma2 differ from activation by Rac2 and from each other. | Differential regulation of phospholipase C-beta2 activity and membrane interaction by Galphaq, Gbeta1gamma2, and Rac2.
Gutman O, Walliser C, Piechulek T, Gierschik P, Henis YI., Free PMC Article | 04/12/2010 |
| receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner | Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner.
Idkowiak-Baldys J, Baldys A, Raymond JR, Hannun YA., Free PMC Article | 01/21/2010 |
| associated with Libman-Sacks endocarditis, cardiac manifestation of SLE | Revisiting Libman-Sacks endocarditis: a historical review and update.
Lee JL, Naguwa SM, Cheema GS, Gershwin ME. | 01/21/2010 |
| all IGF2 actions were exerted predominantly through IGF2R-linked G(i) protein signaling and required intracellular Ca(2+) mobilization induced by the beta2 isoform of phospholipase C in endothelial progenitor cell homing | Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCbeta2 axis.
Maeng YS, Choi HJ, Kwon JY, Park YW, Choi KS, Min JK, Kim YH, Suh PG, Kang KS, Won MH, Kim YM, Kwon YG. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesAn approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K. Association between common variation in genes encoding sweet taste signaling components and human sucrose perception.
Fushan AA, Simons CT, Slack JP, Drayna D. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability.
Morris DW, Ivanov D, Robinson L, Williams N, Stevenson J, Owen MJ, Williams J, O'Donovan MC. | 03/13/2008 |
| May constitute a molecular marker of breast tumor cells able to monitor the progression to invasive cancers and a target for novel therapeutic breast cancer strategies. | Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells.
Bertagnolo V, Benedusi M, Brugnoli F, Lanuti P, Marchisio M, Querzoli P, Capitani S. | 01/21/2010 |
| Both PLC-beta2 isoforms are expressed at the protein level in platelets. In transfected CV-1 cells, PLC-beta2a is more enriched in the nuclei than PLC-beta2b. The two variants may have different effects in cell proliferation and differentiation. | Alternative splice variants of phospholipase C-beta2 are expressed in platelets: effect on Galphaq-dependent activation and localization.
Sun L, Mao G, Kunapuli SP, Dhanasekaran DN, Rao AK. | 01/21/2010 |
| PLCB2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors. | PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors.
Brugnoli F, Bavelloni A, Benedusi M, Capitani S, Bertagnolo V. | 01/21/2010 |
| up-regulated during granulocytic differenetiation of normal and leukemic hematopoietic progenitors | Selective up-regulation of phospholipase C-beta2 during granulocytic differentiation of normal and leukemic hematopoietic progenitors.
Bertagnolo V, Marchisio M, Pierpaoli S, Colamussi ML, Brugnoli F, Visani G, Zauli G, Capitani S. | 01/21/2010 |