| One recurrent heterozygous mutation of the PLCD1 gene in a Chinese family with hereditary leukonychia: A case report and genotype-phenotype correlation analysis. | One recurrent heterozygous mutation of the PLCD1 gene in a Chinese family with hereditary leukonychia: A case report and genotype-phenotype correlation analysis.
Zhang F, Chen Y, Song D, Wang S. | 03/22/2024 |
| MicroRNA-191 regulates oral squamous cell carcinoma cells growth by targeting PLCD1 via the Wnt/beta-catenin signaling pathway. | MicroRNA-191 regulates oral squamous cell carcinoma cells growth by targeting PLCD1 via the Wnt/β-catenin signaling pathway.
Wang Z, Guan W, Ma Y, Zhou X, Song G, Wei J, Wang C., Free PMC Article | 07/24/2023 |
| lncRNA MIR503HG Targets miR-191-5p/PLCD1 Axis and Negatively Modulates Apoptosis, Extracellular Matrix Disruption, and Inflammation in Abdominal Aortic Aneurysm. | lncRNA MIR503HG Targets miR-191-5p/PLCD1 Axis and Negatively Modulates Apoptosis, Extracellular Matrix Disruption, and Inflammation in Abdominal Aortic Aneurysm.
Tian Y, Li X, Bai C, Yang Z, Zhang L, Luo J, Zhang W., Free PMC Article | 06/12/2023 |
| Identification of a Novel PLCD1 Variant in a Danish Family with Hereditary Leukonychia. | Identification of a Novel PLCD1 Variant in a Danish Family with Hereditary Leukonychia.
Lieberoth S, Kumar S, Brusgaard K, Ousager LB, Betz RC, Bygum A. | 03/30/2023 |
| Phospholipase C delta 1 inhibits WNT/beta-catenin and EGFR-FAK-ERK signaling and is disrupted by promoter CpG methylation in renal cell carcinoma. | Phospholipase C delta 1 inhibits WNT/β-catenin and EGFR-FAK-ERK signaling and is disrupted by promoter CpG methylation in renal cell carcinoma.
Xie J, Zhou J, Xia J, Zeng Y, Huang G, Zeng W, Fan T, Li L, Zeng X, Tao Q., Free PMC Article | 03/6/2023 |
| The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1. | The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1.
Sanchez-Solana B, Wang D, Qian X, Velayoudame P, Simanshu DK, Acharya JK, Lowy DR., Free PMC Article | 02/26/2022 |
| Germline Mutation of PLCD1 Contributes to Human Multiple Pilomatricomas through Protein Kinase D/Extracellular Signal-Regulated Kinase1/2 Cascade and TRPV6. | Germline Mutation of PLCD1 Contributes to Human Multiple Pilomatricomas through Protein Kinase D/Extracellular Signal-Regulated Kinase1/2 Cascade and TRPV6.
Liu K, Luo J, Ma T, Fang M, Xu Z, Wang L, Zhang XY, Wen J, Liu C, Cao Y, Li X, Zhang L, Guo A, Wang N, Yi P, Liu JY. | 12/25/2021 |
| Identification of two novel mutations in the PLCD1 gene in Chinese patients with hereditary leukonychia. | Identification of two novel mutations in the PLCD1 gene in Chinese patients with hereditary leukonychia.
Shen S, Shao M, Keyal U, Wang X, Li M, Zhang G., Free PMC Article | 05/15/2021 |
| PLCD1 Suppressed Cellular Proliferation, Invasion, and Migration via Inhibition of Wnt/beta-Catenin Signaling Pathway in Esophageal Squamous Cell Carcinoma. | PLCD1 Suppressed Cellular Proliferation, Invasion, and Migration via Inhibition of Wnt/β-Catenin Signaling Pathway in Esophageal Squamous Cell Carcinoma.
He X, Meng F, Yu ZJ, Zhu XJ, Qin LY, Wu XR, Liu ZL, Li Y, Zheng YF. | 05/1/2021 |
| Phospholipase C controls chloride-dependent short-circuit current in human bronchial epithelial cells. | Phospholipase C controls chloride-dependent short-circuit current in human bronchial epithelial cells.
Grebert C, Becq F, Vandebrouck C. | 03/28/2021 |
| Hereditary Trichilemmal Cysts are Caused by Two Hits to the Same Copy of the Phospholipase C Delta 1 Gene (PLCD1). | Hereditary Trichilemmal Cysts are Caused by Two Hits to the Same Copy of the Phospholipase C Delta 1 Gene (PLCD1).
Kolodney MS, Coman GC, Smolkin MB, Hagen R, Katzman JA, Katzman SN, Holliday AC, Kolodney JA., Free PMC Article | 12/5/2020 |
| tumor-specific methylation of PLCD1 could be used as a novel biomarker for early detection and prognostic prediction in colorectal cancer. | The phosphoinositide hydrolase phospholipase C delta1 inhibits epithelial-mesenchymal transition and is silenced in colorectal cancer.
Xiang Q, He X, Mu J, Mu H, Zhou D, Tang J, Xiao Q, Jiang Y, Ren G, Xiang T, Peng W. | 05/23/2020 |
| Epidermal loss of phospholipase C delta 1 attenuates croton oil - induced irritant contact dermatitis. | Epidermal loss of phospholipase Cδ1 attenuates irritant contact dermatitis.
Shiratori K, Kanemaru K, Ogura T, Nakajima A, Sugizaki Y, Fukuyama T, Iwakura Y, Nakamura Y, Fukami K. | 12/28/2019 |
| For the first time, a hereditary leukonychia case with PLCD1 mutation has been described in Chinese Han pedigree. This finding suggests the PLCD1 mutation maybe involved in hereditary leukonychia. | Identification of a novel PLCD1 mutation in Chinese Han pedigree with hereditary leukonychia and koilonychia.
Xue K, Zheng Y, Shen C, Cui Y. | 12/14/2019 |
| A loss of epidermal PLCdelta1 impairs epidermal barrier function through dysregulation of Ca2+ and p38 mitogen-activated protein kinase (MAPK) signaling. This study also reveals a possible link among PLCdelta1 downregulation, p38 MAPK hyperactivation, and barrier defects in psoriasis-like skin inflammation. | Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity.
Kanemaru K, Nakamura Y, Totoki K, Fukuyama T, Shoji M, Kaneko H, Shiratori K, Yoneda A, Inoue T, Iwakura Y, Kabashima K, Fukami K., Free PMC Article | 03/31/2018 |
| PLCD1 acts as a tumour suppressor, by KIF3A-mediated suppression of ERK1/2/beta-catenin/MMP7 signalling, at least in part, in breast cancer. | Phospholipase Cδ1 suppresses cell migration and invasion of breast cancer cells by modulating KIF3A-mediated ERK1/2/β- catenin/MMP7 signalling.
Shao Q, Luo X, Yang D, Wang C, Cheng Q, Xiang T, Ren G., Free PMC Article | 03/10/2018 |
| Nine of the 32 (28.1%) iCCA patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 mutations, two each (6.3%) of CACNA2D3 and RASSF1 mutations, and one each (3.1%) of ATG7 and PLCD1 mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations. | Mutations of candidate tumor suppressor genes at chromosome 3p in intrahepatic cholangiocarcinoma.
You HL, Huang WT, Liu TT, Weng SW, Eng HL. | 12/9/2017 |
| The PLCdelta1 negatively regulates autophagy, and PLCdelta1 suppression contributes to the tolerance of CRC cells harboring KRAS mutations to nutrient deprivation and anti-cancer drug treatment. | Phospholipase C δ1 negatively regulates autophagy in colorectal cancer cells.
Shimozawa M, Anzai S, Satow R, Fukami K. | 10/7/2017 |
| Phospholipase C delta 1 is both a KLF15-regulated gene and a novel repressor of airway smooth muscle hypertrophy. | Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy.
Sasse SK, Kadiyala V, Danhorn T, Panettieri RA Jr, Phang TL, Gerber AN., Free PMC Article | 08/19/2017 |
| High PLC delta expression is associated with breast cancer. | Expression of phospholipase C isozymes in human breast cancer and their clinical significance.
Cai S, Sun PH, Resaul J, Shi L, Jiang A, Satherley LK, Davies EL, Ruge F, Douglas-Jones A, Jiang WG, Ye L. | 07/15/2017 |
| slow phase of Gi/o-mediated TRPC4 activation was diminished by inhibiting RhoA or enhancing PLCdelta function | Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels.
Thakur DP, Tian JB, Jeon J, Xiong J, Huang Y, Flockerzi V, Zhu MX., Free PMC Article | 06/28/2016 |
| Both unsaturated and saturated dioleoyl-phosphatidylinositol-(4,5)-bisphosphate successfully recruited PHPLCdelta1 to cell membranes. | Phosphatidylinositol-(4,5)-Bisphosphate Acyl Chains Differentiate Membrane Binding of HIV-1 Gag from That of the Phospholipase Cδ1 Pleckstrin Homology Domain.
Olety B, Veatch SL, Ono A., Free PMC Article | 12/12/2015 |
| Neuropeptide Y decreased PLCD1 expression in HUVECs. | Neuropeptide Y reduces the expression of PLCB2, PLCD1 and selected PLC genes in cultured human endothelial cells.
Lo Vasco VR, Leopizzi M, Puggioni C, Della Rocca C, Businaro R. | 10/31/2015 |
| PLC-delta1 and TRPV6 are critical actor of Ca(2+) homeostasis in CF human bronchial epithelial cells. | The low PLC-δ1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity.
Vachel L, Norez C, Jayle C, Becq F, Vandebrouck C. | 09/12/2015 |
| Ectopic expression of PLCD1 inhibits breast tumor cell proliferation in vivo by inducing apoptosis and suppressed tumor cell migration by regulating cytoskeletal reorganization. | Methylation of PLCD1 and adenovirus-mediated PLCD1 overexpression elicits a gene therapy effect on human breast cancer.
Mu H, Wang N, Zhao L, Li S, Li Q, Chen L, Luo X, Qiu Z, Li L, Ren G, Xu Y, Zhou X, Xiang T. | 05/16/2015 |