| FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression. | FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression.
Wang J, Wang C, Hu A, Yu K, Kuang Y, Gajendran B, Zacksenhaus E, Sample KM, Xiao X, Liu W, Ben-David Y., Free PMC Article | 03/28/2024 |
| Replication of association at the LPP and UBASH3A loci in a UK autoimmune Addison's disease cohort. | Replication of association at the LPP and UBASH3A loci in a UK autoimmune Addison's disease cohort.
Howarth S, Sneddon G, Allinson KR, Razvi S, Mitchell AL, Pearce SHS. | 01/28/2023 |
| CRKL, AIFM3, AIF, BCL2, and UBASH3A during Human Kidney Development. | CRKL, AIFM3, AIF, BCL2, and UBASH3A during Human Kidney Development.
Lozic M, Minarik L, Racetin A, Filipovic N, Saraga Babic M, Vukojevic K., Free PMC Article | 10/16/2021 |
| Upon TCR engagement, UBASH3A enhances the downmodulation of cell-surface TCR-CD3. | UBASH3A Regulates the Synthesis and Dynamics of TCR-CD3 Complexes.
Ge Y, Paisie TK, Chen S, Concannon P., Free PMC Article | 05/30/2020 |
| observations suggested that the dysregulation of UBASH3A might be associated with the pathogenesis of rheumatoid arthritis (RA), and UBASH3A gene polymorphisms (rs1893592 and rs3788013) might contribute to RA susceptibility in Chinese Han population. | UBASH3A gene polymorphisms and expression profile in rheumatoid arthritis.
Yang XK, Liu J, Chen SY, Li M, Zhang MM, Leng RX, Pan HF, Shen Y, Liu WX, Xu SQ, Ye DQ, Shuai ZW. | 04/4/2020 |
| this reduction in UBASH3A, as a consequence of the minor allele at rs1893592, resulted in increased secretion of IL-2, a key cytokine that is required for T-cell activation and function but is deficient in some type 1 diabetes (T1D). Our study provides new mechanistic insights into how rs1893592 affects T1D and autoimmunity and how interactions between multiple T1D-associated, noncoding variants influence the disease risk | Molecular-genetic characterization of common, noncoding UBASH3A variants associated with type 1 diabetes.
Ge Y, Concannon P., Free PMC Article | 02/23/2019 |
| UBASH3A gene SNP is associated with susceptibility to atopic dermatitis in Chinese Han population. | Association of UBASH3A gene polymorphism and atopic dermatitis in the Chinese Han population.
Li Y, Cheng H, Xiao FL, Liang B, Zhou FS, Li P, Zheng XD, Sun LD, Yang S, Zhang XJ. | 02/10/2018 |
| UBASH3A attenuates the NF-kappaB signal transduction upon T-cell receptor (TCR) stimulation by specifically suppressing the activation of the IkappaB kinase complex. UBASH3A interacts with TAK1 and NEMO, suggesting that UBASH3A regulates the NF-kappaB signaling pathway by an ubiquitin-dependent mechanism. T1D risk alleles at rs11203203 and rs80054410 increase UBASH3A expression in CD4(+) T cells upon TCR stimulation. | UBASH3A Mediates Risk for Type 1 Diabetes Through Inhibition of T-Cell Receptor-Induced NF-κB Signaling.
Ge Y, Paisie TK, Newman JRB, McIntyre LM, Concannon P., Free PMC Article | 09/2/2017 |
| A negative correlation was found between UBASH3A mRNA expression and systemic lupus erythematosus. | Decreased UBASH3A mRNA Expression Levels in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus.
Liu J, Ni J, Li LJ, Leng RX, Pan HF, Ye DQ. | 06/28/2016 |
| Findings suggest that UBASH3A gene might contribute to systemic lupus erythematosus susceptibility and influence the clinical phenotype of the disease. | Association of UBASH3A gene polymorphisms and systemic lupus erythematosus in a Chinese population.
Liu J, Liu J, Ni J, Leng RX, Pan HF, Ye DQ. | 07/4/2015 |
| these results have suggested that the allele A of two SNPs may play no role in the pathogenesis of autoimmune thyroid disease or that its effect may be confounded by other various factors. | Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study.
Cai T, Wang X, Muhali FS, Song R, Shi X, Jiang W, Xiao L, Li D, Zhang J. | 05/23/2015 |
| Addition of PTPN22 and UBASH3A SNPs to HLA-DR,DQ genotyping can improve type 1 diabetes risk prediction. | Improving prediction of type 1 diabetes by testing non-HLA genetic variants in addition to HLA markers.
Steck AK, Dong F, Wong R, Fouts A, Liu E, Romanos J, Wijmenga C, Norris JM, Rewers MJ., Free PMC Article | 04/4/2015 |
| Results suggest that UBASH3a gene plays a role in the susceptibility to systemic lupus erythematosus and UBASH3a can be considered as a common genetic factor in autoimmune diseases. | Evidence of new risk genetic factor to systemic lupus erythematosus: the UBASH3A gene.
Diaz-Gallo LM, Sánchez E, Ortego-Centeno N, Sabio JM, García-Hernández FJ, de Ramón E, González-Gay MA, Torsten Witte, Anders HJ, González-Escribano MF, Martin J., Free PMC Article | 09/28/2013 |
| ubiquitin associated and SH3 domain containing A appears to be an independent predictor of islet autoimmunity and type 1 diabetes in children, including those free of family history of T1D but carrying the HLA-DR3/4,DQB1*0302 genotype | rs11203203 is associated with type 1 diabetes risk in population pre-screened for high-risk HLA-DR,DQ genotypes.
Johnson K, Wong R, Barriga KJ, Klingensmith G, Ziegler AG, Rewers MJ, Steck AK., Free PMC Article | 05/4/2013 |
| The UBASH3A promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells. | Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.
Warnatz HJ, Querfurth R, Guerasimova A, Cheng X, Haas SA, Hufton AL, Manke T, Vanhecke D, Nietfeld W, Vingron M, Janitz M, Lehrach H, Yaspo ML., Free PMC Article | 09/14/2011 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.
Grant SF, Qu HQ, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Taback SP, Frackelton EC, Eckert AW, Annaiah K, Lawson ML, Otieno FG, Santa E, Shaner JL, Smith RM, Skraban R, Imielinski M, Chiavacci RM, Grundmeier RW, Stanley CA, Kirsch SE, Waggott D, Paterson AD, Monos DS, DCCT/EDIC Research Group, Polychronakos C, Hakonarson H., Free PMC Article | 12/2/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesInvestigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.
Hinks A, Martin P, Flynn E, Eyre S, Packham J, Barton A, Childhood Arthritis Prospective Study (CAPS), UKRAG Consortium, BSPAR study group, Worthington J, Thomson W. Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
Jin Y, Birlea SA, Fain PR, Gowan K, Riccardi SL, Holland PJ, Mailloux CM, Sufit AJ, Hutton SM, Amadi-Myers A, Bennett DC, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taïeb A, Jouary T, Ezzedine K, van Geel N, Lambert J, Overbeck A, Spritz RA. Shared and distinct genetic variants in type 1 diabetes and celiac disease.
Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA. | 01/11/2009 |
| TULA proteins TULA and TULA-2 regulate activity of the protein tyrosine kinase Syk | TULA proteins regulate activity of the protein tyrosine kinase Syk.
Agrawal R, Carpino N, Tsygankov A. | 01/21/2010 |
| Binds to ABCE-1 and inhibits HIV-1 life cycle, most likely by disrupting essential ubiquitylation-dependent events. | TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion.
Smirnova EV, Collingwood TS, Bisbal C, Tsygankova OM, Bogush M, Meinkoth JL, Henderson EE, Annan RS, Tsygankov AY. | 01/21/2010 |
| TULA enhances the apoptotic effect of AIF by facilitating the interactions of AIF with its apoptotic co-factors | T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis.
Collingwood TS, Smirnova EV, Bogush M, Carpino N, Annan RS, Tsygankov AY. | 01/21/2010 |
| TULA inhibits both clathrin-dependent and clathrin-independent endocytic pathways by functionally sequestering dynamin via the SH3 domain of TULA binding proline-rich sequences in dynamin | The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis.
Bertelsen V, Breen K, Sandvig K, Stang E, Madshus IH. | 01/21/2010 |
| Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases | Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.
Kowanetz K, Crosetto N, Haglund K, Schmidt MHH, Heldin CH, Dikic I. | 01/21/2010 |