| Shc3 facilitates breast cancer drug resistance by interacting with ErbB2 to initiate ErbB2/COX2/MDR1 axis. | Shc3 facilitates breast cancer drug resistance by interacting with ErbB2 to initiate ErbB2/COX2/MDR1 axis.
Liu Y, Cao F, Xia F, Li J, Dong X, Guo Y, Zhang J, Zhao Q, Liu Y., Free PMC Article | 06/2/2023 |
| The Shc protein Rai enhances T-cell survival under hypoxia. | The Shc protein Rai enhances T-cell survival under hypoxia.
Criscuoli M, Ulivieri C, Filippi I, Monaci S, Guerrini G, Crifò B, De Tommaso D, Pelicci G, Baldari CT, Taylor CT, Carraro F, Naldini A. | 03/13/2021 |
| our results indicate the importance of Shc3 in HCC progression and identify Shc3 as a novel biomarker and potential therapeutic target in HCC.Significance: Ectopic expression of Shc3 forms a complex with MVP/MEK/ERK to potentiate ERK activation and plays an important role in sorafinib resistance in HCC. | Demethylation-Induced Overexpression of Shc3 Drives c-Raf-Independent Activation of MEK/ERK in HCC.
Liu Y, Zhang X, Yang B, Zhuang H, Guo H, Wei W, Li Y, Chen R, Li Y, Zhang N. | 05/25/2019 |
| We may conclude that RAI plays an important role in hypoxic signaling in Neuroblastoma (NB)cells and the interplay between RAI and HIF-1alpha may be relevant in the protection of NB cells against hypoxia. Our results may contribute to a further understanding the physiology of NB cells and the molecular mechanisms involved in their survival, with important implications in NB progression | The Shc protein RAI promotes an adaptive cell survival program in hypoxic neuroblastoma cells.
Criscuoli M, Filippi I, Osti D, Aldinucci C, Guerrini G, Pelicci G, Carraro F, Naldini A. | 02/23/2019 |
| High SHC3 expression is associated with glioblastoma. | Cell density modulates SHC3 expression and survival of human glioblastoma cells through Fak activation.
Azzalin A, Moretti E, Arbustini E, Magrassi L. | 10/17/2015 |
| Rai (ShcC/N-Shc), a member of the family of Shc-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells. | Rai is a new regulator of neural progenitor migration and glioblastoma invasion.
Ortensi B, Osti D, Pellegatta S, Pisati F, Brescia P, Fornasari L, Levi D, Gaetani P, Colombo P, Ferri A, Nicolis S, Finocchiaro G, Pelicci G. | 08/4/2012 |
| Polymorphism in RAI and CD3EAP are associated with outcome of myeloma patients treated with high dose treatment. | The importance of a sub-region on chromosome 19q13.3 for prognosis of multiple myeloma patients after high-dose treatment and stem cell support: a linkage disequilibrium mapping in RAI and CD3EAP.
Vangsted AJ, Klausen TW, Gimsing P, Abildgaard N, Andersen NF, Gregersen H, Nexø BA, Vogel UB. | 07/2/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| amplification of SHC3 and EDG3 genes suggests that the two proteins co-operate and are important for ependymomas in vivo. | EDG3 and SHC3 on chromosome 9q22 are co-amplified in human ependymomas.
Magrassi L, Marziliano N, Inzani F, Cassini P, Chiaranda I, Skrap M, Pizzolito S, Arienta C, Arbustini E. | 04/12/2010 |
| ShcC is a therapeutic target that might induce differentiation in the aggressive type of neuroblastomas. | Distinct role of ShcC docking protein in the differentiation of neuroblastoma.
Miyake I, Ohira M, Nakagawara A, Sakai R. | 01/21/2010 |
| shcc is expressed in the human gut, especially in the enteric glial cells | Expression of the Rai (Shc C) adaptor protein in the human enteric nervous system.
Villanacci V, Bassotti G, Ortensi B, Fisogni S, Cathomas G, Maurer CA, Galletti A, Salerni B, Pelicci G. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence.
Li MD, Sun D, Lou XY, Beuten J, Payne TJ, Ma JZ, Li MD, Sun D, Lou XY, Beuten J, Payne TJ, Ma JZ. | 03/13/2008 |
| ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma cells | Domain-specific function of ShcC docking protein in neuroblastoma cells.
Miyake I, Hakomori Y, Misu Y, Nakadate H, Matsuura N, Sakamoto M, Sakai R. | 01/21/2010 |
| data suggest that RAI (ShcC/H-Shc)is a critical substrate for RET oncoproteins in thyroid carcinomas | RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors.
De Falco V, Guarino V, Malorni L, Cirafici AM, Troglio F, Erreni M, Pelicci G, Santoro M, Melillo RM. | 01/21/2010 |
| The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells. | Shc3 affects human high-grade astrocytomas survival.
Magrassi L, Conti L, Lanterna A, Zuccato C, Marchionni M, Cassini P, Arienta C, Cattaneo E. | 01/21/2010 |
| Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. | Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.
Tarr PE, Roncarati R, Pelicci G, Pelicci PG, D'Adamio L. | 01/21/2010 |
| The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway. | The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.
Pelicci G, Troglio F, Bodini A, Melillo RM, Pettirossi V, Coda L, De Giuseppe A, Santoro M, Pelicci PG., Free PMC Article | 01/21/2010 |
| 11 SNPs within SHC3 were examined to determine the association with nicotine dependence (ND) in either African-Americans (AA) or European-Americans (EA); three SNPs for AAs and one for EAs were significantly associated with at least one ND. | Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence.
Li MD, Sun D, Lou XY, Beuten J, Payne TJ, Ma JZ, Li MD, Sun D, Lou XY, Beuten J, Payne TJ, Ma JZ. | 01/21/2010 |
| ALK-ShcC signal activation, possibly caused by co-amplification with the N-myc gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK kinase. | Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines.
Miyake I, Hakomori Y, Shinohara A, Gamou T, Saito M, Iwamatsu A, Sakai R. | 01/21/2010 |