| TPC1 is involved in the norepinephrine (NE)-stimulated [Ca(2+)]i rise in Smooth muscle cells. Inhibition of TPC1 activity by NED 19 could be the reason for partial inhibition of aortic rings contraction in response to NE. | The Role of Two-Pore Channels in Norepinephrine-Induced [Ca(2+)](i) Rise in Rat Aortic Smooth Muscle Cells and Aorta Contraction.
Trufanov SK, Rybakova EY, Avdonin PP, Tsitrina AA, Zharkikh IL, Goncharov NV, Jenkins RO, Avdonin PV., Free PMC Article | 06/20/2020 |
| cryo-EM structure of human TPC2 provides insights into the mechanism of PI(3,5)P2-regulated gating of TPC2, which is distinct from that of TPC1 | Structural mechanisms of phospholipid activation of the human TPC2 channel.
She J, Zeng W, Guo J, Chen Q, Bai XC, Jiang Y., Free PMC Article | 04/25/2020 |
| These data point to a process in which Ca(2+) permeation in human TPC1 has a positive feedback on channel activity while Na(+) acts as a negative regulator. | The human two-pore channel 1 is modulated by cytosolic and luminal calcium.
Lagostena L, Festa M, Pusch M, Carpaneto A., Free PMC Article | 11/10/2018 |
| a cluster of arginine residues in the first domain required for selective voltage-gating of TPC1 map not to the voltage-sensing fourth transmembrane region (S4) but to a cytosolic downstream region (S4-S5 linker). | NAADP-evoked Ca(2+) signals through two-pore channel-1 require arginine residues in the first S4-S5 linker.
Patel S, Churamani D, Brailoiu E., Free PMC Article | 06/23/2018 |
| These findings indicate potential differential regulation of signaling processes by TPC1 and TPC2 in breast cancer cells. | Differential effects of two-pore channel protein 1 and 2 silencing in MDA-MB-468 breast cancer cells.
Jahidin AH, Stewart TA, Thompson EW, Roberts-Thomson SJ, Monteith GR. | 05/20/2017 |
| Studies suggest that both two-pore channels TPC1 and TPC2 as nicotinic acid adenine dinucleotide phosphate (NAADP) targets. | Function and dysfunction of two-pore channels.
Patel S. | 04/23/2016 |
| The TPC1 was shown to interact with citron kinase, with TPC1 overexpression affecting RhoA activity and myosin light chain phosphorylation levels in cytokinesis. | Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis.
Horton JS, Wakano CT, Speck M, Stokes AJ., Free PMC Article | 12/12/2015 |
| NAADP induced marked Ca(2+) transients in HEK293 cells that stably coexpressed hTPC2 with hTPC1 or cTPC3, but failed to evoke any such response in cells that coexpressed interacting hTPC2 and rTPC3 subunits | Organelle-specific subunit interactions of the vertebrate two-pore channel family.
Ogunbayo OA, Zhu Y, Shen B, Agbani E, Li J, Ma J, Zhu MX, Evans AM., Free PMC Article | 04/25/2015 |
| TPC2, but not TPC1, caused a proliferation of endolysosomal structures, dysregulating intracellular trafficking, and cellular pigmentation. | The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation.
Lin-Moshier Y, Keebler MV, Hooper R, Boulware MJ, Liu X, Churamani D, Abood ME, Walseth TF, Brailoiu E, Patel S, Marchant JS., Free PMC Article | 04/25/2015 |
| TPC1 and TPC2 proteins play a key role in Ebola virus infection and may be effective targets for antiviral therapy. | Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.
Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA., Free PMC Article | 04/4/2015 |
| NAADP triggers H+ release from lysosomes and endolysomes through activation of TPC1, but that the Ca2+ -releasing ability of TPC1 will depend on the ionic composition of the acidic stores | Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+.
Pitt SJ, Lam AK, Rietdorf K, Galione A, Sitsapesan R., Free PMC Article | 02/14/2015 |
| TPC1 is a member of a new family of voltage-gated Na(+) channels that senses pH changes and confers electrical excitability to organelles. | The voltage-gated sodium channel TPC1 confers endolysosomal excitability.
Cang C, Bekele B, Ren D. | 07/19/2014 |
| The concerted regulation of TPC1 activity by luminal Ca(2+) and by membrane potential thus provides a potential mechanism to explain NAADP-induced Ca(2+) oscillations. | Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1.
Rybalchenko V, Ahuja M, Coblentz J, Churamani D, Patel S, Kiselyov K, Muallem S., Free PMC Article | 09/22/2012 |
| OsTPC1 plays a crucial role in TvX-induced Ca(2+) influx as a plasma membrane Ca(2+)-permeable channel consequently required for the regulation of phytoalexin biosynthesis | Regulation of a proteinaceous elicitor-induced Ca2+ influx and production of phytoalexins by a putative voltage-gated cation channel, OsTPC1, in cultured rice cells.
Hamada H, Kurusu T, Okuma E, Nokajima H, Kiyoduka M, Koyano T, Sugiyama Y, Okada K, Koga J, Saji H, Miyao A, Hirochika H, Yamane H, Murata Y, Kuchitsu K., Free PMC Article | 05/19/2012 |
| Data show that human two-pore channel TPC1 is critical for nicotinic acid adenine dinucleotide phosphate action and is likely the long sought after target channel for NAADP. | Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling.
Brailoiu E, Churamani D, Cai X, Schrlau MG, Brailoiu GC, Gao X, Hooper R, Boulware MJ, Dun NJ, Marchant JS, Patel S., Free PMC Article | 01/21/2010 |