| Essential role of PLD2 in hypoxia-induced stemness and therapy resistance in ovarian tumors. | Essential role of PLD2 in hypoxia-induced stemness and therapy resistance in ovarian tumors.
Muñoz-Galván S, Verdugo-Sivianes EM, Santos-Pereira JM, Estevez-García P, Carnero A., Free PMC Article | 04/17/2024 |
| Phospholipase D and cancer metastasis: A focus on exosomes. | Phospholipase D and cancer metastasis: A focus on exosomes.
Wolf A, Tanguy E, Wang Q, Gasman S, Vitale N. | 03/14/2023 |
| PLD2 deletion alleviates disruption of tight junctions in sepsis-induced ALI by regulating PA/STAT3 phosphorylation pathway. | PLD2 deletion alleviates disruption of tight junctions in sepsis-induced ALI by regulating PA/STAT3 phosphorylation pathway.
Qian T, Qi B, Fei Y, Li J, Luo L, Lv B, Song Y, Sheng S, Xiao W, Huang X, Wang X. | 02/4/2023 |
| Exosome Secretion and Epithelial-Mesenchymal Transition in Ovarian Cancer Are Regulated by Phospholipase D. | Exosome Secretion and Epithelial-Mesenchymal Transition in Ovarian Cancer Are Regulated by Phospholipase D.
Onallah H, Mannully ST, Davidson B, Reich R., Free PMC Article | 11/26/2022 |
| Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1. | Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1.
Lee H, Jung TY, Lim SH, Choi EJ, Lee J, Min DS., Free PMC Article | 04/2/2022 |
| Structure and regulation of human phospholipase D. | Structure and regulation of human phospholipase D.
Bowling FZ, Frohman MA, Airola MV., Free PMC Article | 10/30/2021 |
| Identification and functional analysis of a novel phospholipase D2 gene mutation associated with familial systemic lupus erythematosus.", trans "PLD2. | Identification and functional analysis of a novel phospholipase D2 gene mutation associated with familial systemic lupus erythematosus.
Peng L, Yuan X, Chen L, Chen S, Chen K., Free PMC Article | 05/8/2021 |
| Increased phospholipase D activity contributes to tumorigenesis in prostate cancer cell models. | Increased phospholipase D activity contributes to tumorigenesis in prostate cancer cell models.
Borel M, Cuvillier O, Magne D, Mebarek S, Brizuela L. | 05/1/2021 |
| Prostate cancer-derived exosomes promote osteoblast differentiation and activity through phospholipase D2. | Prostate cancer-derived exosomes promote osteoblast differentiation and activity through phospholipase D2.
Borel M, Lollo G, Magne D, Buchet R, Brizuela L, Mebarek S. | 01/23/2021 |
| High Expression of PhospholipaseD2 Induced by Hypoxia Promotes Proliferation of Colon Cancer Cells through Activating NF- kappa Bp65 Signaling Pathway. | High Expression of PhospholipaseD2 Induced by Hypoxia Promotes Proliferation of Colon Cancer Cells through Activating NF- κ Bp65 Signaling Pathway.
Liu M, Du K, Jiang B, Wu X. | 01/16/2021 |
| Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation. | Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation.
Fu P, Ramchandran R, Shaaya M, Huang L, Ebenezer DL, Jiang Y, Komarova Y, Vogel SM, Malik AB, Minshall RD, Du G, Tonks NK, Natarajan V., Free PMC Article | 12/26/2020 |
| PLD2-PI(4,5)P2 interactions in fluid phase membranes: Structural modeling and molecular dynamics simulations. | PLD2-PI(4,5)P2 interactions in fluid phase membranes: Structural modeling and molecular dynamics simulations.
Han K, Pastor RW, Fenollar-Ferrer C., Free PMC Article | 10/3/2020 |
| PLD2 expression correlates with increasing Gleason score to GS8. PLD2 inhibition has the potential to reduce prostate cancer (PCa) progression. | Phospholipase D2 in prostate cancer: protein expression changes with Gleason score.
Noble AR, Hogg K, Suman R, Berney DM, Bourgoin S, Maitland NJ, Rumsby MG., Free PMC Article | 06/20/2020 |
| Here, expressed were human PLD1 and human PLD2 in Drosophila and the study found that while reconstitution of human PLD1 is able to completely rescue retinal degeneration in a loss of function dPLD mutant, human PLD2 was less effective in its ability to mediate a rescue. | Functional analysis of mammalian phospholipase D enzymes.
Panda A, Thakur R, Krishnan H, Naik A, Shinde D, Raghu P., Free PMC Article | 08/3/2019 |
| High PLD2 expression is associated with atherosclerotic plaques. | Oxidized LDL phagocytosis during foam cell formation in atherosclerotic plaques relies on a PLD2-CD36 functional interdependence.
Ganesan R, Henkels KM, Wrenshall LE, Kanaho Y, Di Paolo G, Frohman MA, Gomez-Cambronero J., Free PMC Article | 04/20/2019 |
| these findings identify a novel pathway through which the lipid signaling enzyme PLD2 regulates blood pressure, creating implications for on-going therapeutic development of PLD small molecule inhibitors. Finally, we show that the human PLD2 polymorphism does not trigger eNOS loss, but rather creates another effect, suggesting altered functioning for the allele. | Phospholipase D2 loss results in increased blood pressure via inhibition of the endothelial nitric oxide synthase pathway.
Nelson RK, Ya-Ping J, Gadbery J, Abedeen D, Sampson N, Lin RZ, Frohman MA., Free PMC Article | 04/6/2019 |
| we demonstrate that tumor cell-secreted PLD2 contributes to tumor development by modifying the microenvironment, making it a possible therapeutic target for cancer treatment. This mechanism may also explain the high levels of Wnt pathway activation in colon cancer. | Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment.
Muñoz-Galván S, Lucena-Cacace A, Perez M, Otero-Albiol D, Gomez-Cambronero J, Carnero A. | 03/9/2019 |
| Data show that phospholipase D2 (PLD2)-produced phosphatidic acid (PA) promoted cell invasion through the the expression of angiogenin (ANG) in clear cell renal cell carcinoma (ccRCC) cells. | Phospholipase D2 promotes disease progression of renal cell carcinoma through the induction of angiogenin.
Kandori S, Kojima T, Matsuoka T, Yoshino T, Sugiyama A, Nakamura E, Shimazui T, Funakoshi Y, Kanaho Y, Nishiyama H., Free PMC Article | 06/23/2018 |
| AQP3 siRNA and PLD2 siRNA significantly downregulated the mRNA and protein levels of AQP3 and PLD2 in the A431 cells; inhibiting proliferation and promoting apoptosis in vitro. | AQP3 small interfering RNA and PLD2 small interfering RNA inhibit the proliferation and promote the apoptosis of squamous cell carcinoma.
Wang X, Tao C, Yuan C, Ren J, Yang M, Ying H., Free PMC Article | 04/14/2018 |
| PLD2 is involved into pathogenesis of a vast array of human diseases, and as such it can be targeted for therapy. (Review) | Accumulating insights into the role of phospholipase D2 in human diseases.
Ghim J, Chelakkot C, Bae YS, Suh PG, Ryu SH. | 11/18/2017 |
| Slug is a positive regulator, and Snail a negative regulator, of PLD2 expression. | The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion.
Ganesan R, Mallets E, Gomez-Cambronero J., Free PMC Article | 10/14/2017 |
| Data suggest that elevated membrane tension acts through phospholipase D2 (PLD2) and the mammalian target of rapamycin complex 2 (mTORC2) to limit actin nucleation. | Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration.
Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD., Free PMC Article | 06/24/2017 |
| results suggest that the small GTPase RalA plays an important role in promoting invagination and trafficking of caveolae, not by potentiating the association between Cav-1 and FilA but by stimulating PLD2-mediated generation of phosphatidic acid. | Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells.
Jiang Y, Sverdlov MS, Toth PT, Huang LS, Du G, Liu Y, Natarajan V, Minshall RD., Free PMC Article | 05/20/2017 |
| Suggest PLD expression in high grade serous ovarian carcinoma may have a role in mediating progression to effusions and chemoresistance. | Phospholipase D messenger RNA expression and clinical role in high-grade serous carcinoma.
Harel-Dassa K, Yedgar S, Tropé CG, Davidson B, Reich R. | 04/29/2017 |
| PLD2 functions as a key mediator in the VEGF-mediated angiogenic functions of endothelial cells. | Loss of phospholipase D2 impairs VEGF-induced angiogenesis.
Lee CS, Ghim J, Song P, Suh PG, Ryu SH., Free PMC Article | 01/28/2017 |