| The mechanism of mitochondrial metabolic gene PMAIP1 involved in Alzheimer's disease process based on bioinformatics analysis and experimental validation. | The mechanism of mitochondrial metabolic gene PMAIP1 involved in Alzheimer's disease process based on bioinformatics analysis and experimental validation.
Ling Y, Hu L, Chen J, Zhao M, Dai X., Free PMC Article | 05/23/2024 |
| Noxa inhibits oncogenesis through ZNF519 in gastric cancer and is suppressed by hsa-miR-200b-3p. | Noxa inhibits oncogenesis through ZNF519 in gastric cancer and is suppressed by hsa-miR-200b-3p.
Shi J, Ding F, Dai D, Song X, Wu X, Yan D, Han X, Tao G, Dai W., Free PMC Article | 03/21/2024 |
| NOXA expression is downregulated in human breast cancer undergoing incomplete pathological response and senescence after neoadjuvant chemotherapy. | NOXA expression is downregulated in human breast cancer undergoing incomplete pathological response and senescence after neoadjuvant chemotherapy.
Al Shboul S, El-Sadoni M, Alhesa A, Abu Shahin N, Abuquteish D, Abu Al Karsaneh O, Alsharaiah E, Ismail MA, Tyutyunyk-Massey L, Alotaibi MR, Neely V, Harada H, Saleh T., Free PMC Article | 12/20/2023 |
| The BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents. | The BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents.
Karbon G, Haschka MD, Hackl H, Soratroi C, Rocamora-Reverte L, Parson W, Fiegl H, Villunger A., Free PMC Article | 04/16/2022 |
| BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer. | BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer.
Shahbandi A, Rao SG, Anderson AY, Frey WD, Olayiwola JO, Ungerleider NA, Jackson JG., Free PMC Article | 11/22/2021 |
| Noxa upregulation and 5-gene apoptotic biomarker panel in colorectal cancer. | Noxa upregulation and 5-gene apoptotic biomarker panel in colorectal cancer.
Kosmidou V, Vlassi M, Anagiotos K, Raftopoulou S, Kalogerakou E, Skarmalioraki S, Aggeli C, Choreftaki T, Zografos G, Pintzas A. | 10/23/2021 |
| Cullin-5 neddylation-mediated NOXA degradation is enhanced by PRDX1 oligomers in colorectal cancer. | Cullin-5 neddylation-mediated NOXA degradation is enhanced by PRDX1 oligomers in colorectal cancer.
Xu S, Ma Y, Tong Q, Yang J, Liu J, Wang Y, Li G, Zeng J, Fang S, Li F, Xie X, Zhang J., Free PMC Article | 09/18/2021 |
| TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia. | TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia.
Ochiiwa H, Ailiken G, Yokoyama M, Yamagata K, Nagano H, Yoshimura C, Muraoka H, Ishida K, Haruma T, Nakayama A, Hashimoto N, Murata K, Nishimura M, Kawashima Y, Ohara O, Ohkubo S, Tanaka T., Free PMC Article | 07/31/2021 |
| NOXA upregulation by the prohibitin-binding compound fluorizoline is transcriptionally regulated by integrated stress response-induced ATF3 and ATF4. | NOXA upregulation by the prohibitin-binding compound fluorizoline is transcriptionally regulated by integrated stress response-induced ATF3 and ATF4.
Núñez-Vázquez S, Sánchez-Vera I, Saura-Esteller J, Cosialls AM, Noisier AFM, Albericio F, Lavilla R, Pons G, Iglesias-Serret D, Gil J. | 07/31/2021 |
| Structural modification of NADPH oxidase activator (Noxa 1) by oxidative stress: An experimental and computational study. | Structural modification of NADPH oxidase activator (Noxa 1) by oxidative stress: An experimental and computational study.
Attri P, Park JH, De Backer J, Kim M, Yun JH, Heo Y, Dewilde S, Shiratani M, Choi EH, Lee W, Bogaerts A. | 04/3/2021 |
| MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation. | MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation.
Arai S, Varkaris A, Nouri M, Chen S, Xie L, Balk SP., Free PMC Article | 03/27/2021 |
| Variants in XPC, Noxa and TLR4 genes are not associated with bleomycin-induced lung injury in Hodgkin lymphoma patients. | Variants in XPC, Noxa and TLR4 genes are not associated with bleomycin-induced lung injury in Hodgkin lymphoma patients.
Thakkar DN, Prapath I, Adithan S, Ramasamy K, Selvarajan S, Dubashi B. | 03/27/2021 |
| Chemical hypoxia induces apoptosis of human pluripotent stem cells by a NOXA-mediated HIF-1alpha and HIF-2alpha independent mechanism. | Chemical hypoxia induces apoptosis of human pluripotent stem cells by a NOXA-mediated HIF-1α and HIF-2α independent mechanism.
Isaja L, Mucci S, Vera J, Rodríguez-Varela MS, Marazita M, Morris-Hanon O, Videla-Richardson GA, Sevlever GE, Scassa ME, Romorini L., Free PMC Article | 03/20/2021 |
| The subsequent downstream effects were NOXA increase. | AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia.
Medeiros HCD, Colturato-Kido C, Ferraz LS, Costa CA, Moraes VWR, Paredes-Gamero EJ, Tersariol ILS, Rodrigues T. | 02/22/2020 |
| CBD induced apoptosis in a Noxa-and-ROS-dependent manner. | Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells.
Jeong S, Yun HK, Jeong YA, Jo MJ, Kang SH, Kim JL, Kim DY, Park SH, Kim BR, Na YJ, Lee SI, Kim HD, Kim DH, Oh SC, Lee DH. | 12/14/2019 |
| Our data showed that Bmi1 is highly expressed in human non-small cell lung cancer (NSCLC) tissues and cell lines. Knockdown of Bmi1 significantly suppressed NSCLC cell proliferation and colony formation. Deguelin treatment attenuated the binding activity of Bmi1 to the Noxa promoter, thus resulting in Noxa transcription and apoptosis activation | Repression of Noxa by Bmi1 contributes to deguelin-induced apoptosis in non-small cell lung cancer cells.
Li W, Yu X, Xia Z, Yu X, Xie L, Ma X, Zhou H, Liu L, Wang J, Yang Y, Liu H., Free PMC Article | 11/2/2019 |
| BIM and NOXA contribute to TAF6delta-dependent cell death. | BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis.
Delannoy A, Wilhelm E, Eilebrecht S, Alvarado-Cuevas EM, Benecke AG, Bell B., Free PMC Article | 06/22/2019 |
| HHT and bortezomib cooperate to kill DLBCL and MCL cells through a process involving MCL-1 down-regulation, NOXA up-regulation. | Homoharringtonine interacts synergistically with bortezomib in NHL cells through MCL-1 and NOXA-dependent mechanisms.
Nguyen T, Parker R, Zhang Y, Hawkins E, Kmieciak M, Craun W, Grant S., Free PMC Article | 03/2/2019 |
| Pharmacologic induction of NOXA, using the histone deacetylase inhibitor panobinostat, decreased MCL1 protein abundance and increased lymphoma cell vulnerability to BCL2 inhibitors in vitro and in vivo. | NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death.
Liu Y, Mondello P, Erazo T, Tannan NB, Asgari Z, de Stanchina E, Nanjangud G, Seshan VE, Wang S, Wendel HG, Younes A., Free PMC Article | 01/26/2019 |
| Data report that NOXA is a physiological substrate of autophagy. Mechanistic studies revealed that NOXA is hijacked by p62 for degradation during the autophagic process, and the three lysine residues at the C-terminus of NOXA are required for its autophagic degradation. Furthermore, autophagy can block apoptosis by eliminating NOXA in both p53-dependent and p53-independent manners. | Autophagy regulates apoptosis by targeting NOXA for degradation.
Wang J, Cui D, Gu S, Chen X, Bi Y, Xiong X, Zhao Y. | 12/22/2018 |
| Fluorizoline increased the protein levels of the pro-apoptotic B-cell lymphoma 2 family member NOXA in chronic lymphocytic leukemia cells. Furthermore, fluorizoline synergized with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax to induce apoptosis. | The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax.
Cosialls AM, Pomares H, Iglesias-Serret D, Saura-Esteller J, Núñez-Vázquez S, González-Gironès DM, de la Banda E, Preciado S, Albericio F, Lavilla R, Pons G, González-Barca EM, Gil J., Free PMC Article | 05/12/2018 |
| By ubiquitylating and degrading NOXA through activating CRL5, UBE2F selectively promotes lung cancer cell survival and could, therefore, serve as a novel cancer target | Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage.
Zhou W, Xu J, Li H, Xu M, Chen ZJ, Wei W, Pan Z, Sun Y., Free PMC Article | 02/17/2018 |
| Data show that Noxa-mediated MCL-1 phosphorylation and degradation is regulated by CDK2. | DNA damaging agent-induced apoptosis is regulated by MCL-1 phosphorylation and degradation mediated by the Noxa/MCL-1/CDK2 complex.
Nakajima W, Sharma K, Lee JY, Maxim NT, Hicks MA, Vu TT, Luu A, Yeudall WA, Tanaka N, Harada H., Free PMC Article | 12/30/2017 |
| the c-FLIP and NOXA/Mcl-1 axis participated in the synergistic effect of pemetrexed plus cisplatin in human choroidal melanoma cells | c-FLIP and the NOXA/Mcl-1 axis participate in the synergistic effect of pemetrexed plus cisplatin in human choroidal melanoma cells.
Zhao X, Kong F, Wang L, Zhang H., Free PMC Article | 10/28/2017 |
| Noxa is involved in X-ray-induced lung injury. | Pro-apoptotic Noxa is involved in ablative focal irradiation-induced lung injury.
Kim JY, An YM, Choi WH, Kim JM, Cho S, Yoo BR, Kang JW, Lee YS, Lee YJ, Cho J., Free PMC Article | 08/12/2017 |