| Pancreatic lipase and its related proteins: where are we now? | Pancreatic lipase and its related proteins: where are we now?
Yadav N, Paul AT. | 01/26/2024 |
| We analyzed mRNA expression in human pancreatic cDNA samples and found the variant allele markedly reduced. We conclude that the p.W358X truncation variant of PNLIPRP2 is expressed poorly and has no significant effect on the risk of chronic pancreatitis | The common truncation variant in pancreatic lipase related protein 2 (PNLIPRP2) is expressed poorly and does not alter risk for chronic pancreatitis.
Németh BC, Pesei ZG, Hegyi E, Szücs Á, Szentesi A, Hegyi P, Lowe ME, Sahin-Tóth M., Free PMC Article | 04/13/2019 |
| findings show that endosomal lipases participate in lipid antigen presentation by processing lipid antigens and have a role in T cell immunity against mycobacteria | Lysosomal Lipases PLRP2 and LPLA2 Process Mycobacterial Multi-acylated Lipids and Generate T Cell Stimulatory Antigens.
Gilleron M, Lepore M, Layre E, Cala-De Paepe D, Mebarek N, Shayman JA, Canaan S, Mori L, Carrière F, Puzo G, De Libero G. | 11/18/2017 |
| The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 | The β5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2).
Xiao X, Lowe ME., Free PMC Article | 03/19/2016 |
| Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase. | Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase.
Johnson K, Ross L, Miller R, Xiao X, Lowe ME., Free PMC Article | 03/1/2014 |
| BSSL and PLRP2 hydrolyzed triglycerides (TG) to free FA and glycerol. | BSSL and PLRP2: key enzymes for lipid digestion in the newborn examined using the Caco-2 cell line.
Andersson EL, Hernell O, Bläckberg L, Fält H, Lindquist S., Free PMC Article | 02/4/2012 |
| Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns | Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns.
Xiao X, Mukherjee A, Ross LE, Lowe ME., Free PMC Article | 10/1/2011 |
| localization of PLRP2 in endosomes of monocytes | Bis (monoacylglycero) phosphate interfacial properties and lipolysis by pancreatic lipase-related protein 2, an enzyme present in THP-1 human monocytes.
Record M, Amara S, Subra C, Jiang G, Prestwich GD, Ferrato F, Carrière F. | 09/3/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A., Free PMC Article | 12/2/2009 |
| The pancreatic lipase related protein 2 is required for lipid-dependent cytotoxicity mediated by cytotoxic T lymphocytes. | Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs).
Alves BN, Marshall K, Tamang DL, Leong J, Redelman D, Elliott V, Lowe ME, Hudig D., Free PMC Article | 01/21/2010 |
| Most of the structural and kinetic properties of HPLRP2 were found to be different from those of rat PLRP2 | Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation.
Eydoux C, Spinelli S, Davis TL, Walker JR, Seitova A, Dhe-Paganon S, De Caro A, Cambillau C, Carrière F. | 01/21/2010 |
| finding that the inhibition of nonproteolyzed rHPLRP2 by tetrahydrolipstatin and diethyl-p-nitrophenyl phosphate does not involve any bile salt requirements suggests that the rHPLRP2 lid adopts an open conformation in aqueous media. | Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells.
Eydoux C, De Caro J, Ferrato F, Boullanger P, Lafont D, Laugier R, Carrière F, De Caro A. | 01/21/2010 |
| Investigation of the substrate specificity of purified recombinant pancreatic lipase-related protein 2 reveals that its physiological role is digestion of galactolipids, the main plant lipids present in the vegetables which are a part of the human diet. | Human pancreatic lipase-related protein 2 is a galactolipase.
Sias B, Ferrato F, Grandval P, Lafont D, Boullanger P, De Caro A, Leboeuf B, Verger R, Carrière F. | 01/21/2010 |
| Patients with chronic calcifying pancreatitis (CCP) had significantly lower levels of both pancreatic lipase and PLRP2 than the controls subjects. | Human pancreatic lipase-related protein 2: tissular localization along the digestive tract and quantification in pancreatic juice using a specific ELISA.
Eydoux C, Aloulou A, De Caro J, Grandval P, Laugier R, Carrière F, De Caro A. | 01/21/2010 |