| DNA polymerase epsilon and delta variants drive mutagenesis in polypurine tracts in human tumors. | DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors.
Ostroverkhova D, Tyryshkin K, Beach AK, Moore EA, Masoudi-Sobhanzadeh Y, Barbari SR, Rogozin IB, Shaitan KV, Panchenko AR, Shcherbakova PV., Free PMC Article | 06/21/2024 |
| Rare germline variants in POLE and POLD1 encoding the catalytic subunits of DNA polymerases epsilon and delta in glioma families. | Rare germline variants in POLE and POLD1 encoding the catalytic subunits of DNA polymerases ε and δ in glioma families.
Weber CAM, Krönke N, Volk V, Auber B, Förster A, Trost D, Geffers R, Esmaeilzadeh M, Lalk M, Nabavi A, Samii A, Krauss JK, Feuerhake F, Hartmann C, Wiese B, Brand F, Weber RG., Free PMC Article | 03/13/2024 |
| POLD1 Is Required for Cell Cycle Progression by Overcoming DNA Damage in Malignant Pleural Mesothelioma. | POLD1 Is Required for Cell Cycle Progression by Overcoming DNA Damage in Malignant Pleural Mesothelioma.
Shimizu D, Ishibashi M, Yamada T, Toda Y, Hosogi S, Ashihara E., Free PMC Article | 03/5/2024 |
| Race, Prevalence of POLE and POLD1 Alterations, and Survival Among Patients With Endometrial Cancer. | Race, Prevalence of POLE and POLD1 Alterations, and Survival Among Patients With Endometrial Cancer.
Zheng S, Donnelly ED, Strauss JB., Free PMC Article | 01/29/2024 |
| DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC. | DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC.
Wang Y, Ju L, Wang G, Qian K, Jin W, Li M, Yu J, Shi Y, Wang Y, Zhang Y, Xiao Y, Wang X., Free PMC Article | 05/8/2023 |
| DNA Polymerase Delta Exhibits Altered Catalytic Properties on Lysine Acetylation. | DNA Polymerase Delta Exhibits Altered Catalytic Properties on Lysine Acetylation.
Njeri C, Pepenella S, Battapadi T, Bambara RA, Balakrishnan L., Free PMC Article | 05/5/2023 |
| Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity. | Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity.
Ma X, Riaz N, Samstein RM, Lee M, Makarov V, Valero C, Chowell D, Kuo F, Hoen D, Fitzgerald CWR, Jiang H, Alektiar J, Alban TJ, Juric I, Parthasarathy PB, Zhao Y, Sabio EY, Verma R, Srivastava RM, Vuong L, Yang W, Zhang X, Wang J, Chu LK, Wang SL, Kelly DW, Pei X, Chen J, Yaeger R, Zamarin D, Zehir A, Gönen M, Morris LGT, Chan TA., Free PMC Article | 07/23/2022 |
| POLE/POLD1 mutation and tumor immunotherapy. | POLE/POLD1 mutation and tumor immunotherapy.
Ma X, Dong L, Liu X, Ou K, Yang L., Free PMC Article | 07/23/2022 |
| Scrutinizing Deleterious Nonsynonymous SNPs and Their Effect on Human POLD1 Gene. | Scrutinizing Deleterious Nonsynonymous SNPs and Their Effect on Human POLD1 Gene.
Bappy MNI, Roy A, Rabbi MGR, Jahan N, Chowdhury FA, Hoque SF, Sajib EH, Khan P, Hossain FMA, Zinnah KMA., Free PMC Article | 06/11/2022 |
| DNA Polymerase Delta 1 Catalytic Subunit (POLD1) as a Prognostic Factor in Clear Cell Renal Cell Carcinoma Patients. | DNA Polymerase Delta 1 Catalytic Subunit (POLD1) as a Prognostic Factor in Clear Cell Renal Cell Carcinoma Patients.
Godlewski J, Stefaniak P, Kiezun J, Krazinski BE., Free PMC Article | 05/14/2022 |
| Solving the enigma of POLD1 p.V295M as a potential cause of increased cancer risk. | Solving the enigma of POLD1 p.V295M as a potential cause of increased cancer risk.
Mur P, Magraner-Pardo L, García-Mulero S, Díez-Villanueva A, Del Valle J, Ezquerro E, Lázaro C, Capellá G, Moreno V, Sanz-Pamplona R, Pons T, Valle L., Free PMC Article | 04/23/2022 |
| DNA polymerase delta Exo domain stabilizes mononucleotide microsatellites in human cells. | DNA polymerase delta Exo domain stabilizes mononucleotide microsatellites in human cells.
Shioi S, Shimamoto A, Song Y, Hidaka K, Nakamura M, Take A, Hayashi N, Takiguchi S, Fujikane R, Hidaka M, Oda S, Nakatsu Y. | 04/2/2022 |
| Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer. | Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer.
Keshinro A, Vanderbilt C, Kim JK, Firat C, Chen CT, Yaeger R, Ganesh K, Segal NH, Gonen M, Shia J, Stadler Z, Weiser MR., Free PMC Article | 03/26/2022 |
| A novel POLD1 pathogenic variant identified in two families with a cancer spectrum mimicking Lynch syndrome. | A novel POLD1 pathogenic variant identified in two families with a cancer spectrum mimicking Lynch syndrome.
Legrand C, Lebrun M, Naïbo P, Peysselon M, Prieur F, Kientz C, Desseigne F, Handallou S, Rey JM, Nambot S, Goussot V, Hamzaoui N, Wang Q. | 03/19/2022 |
| Child to adulthood clinical description of MDPL syndrome due to a novel variant in POLD1. | Child to adulthood clinical description of MDPL syndrome due to a novel variant in POLD1.
Gladys B, René W, Anabelle D, Ahmad M, Caroline F, Etienne S, Deniz K, Valerie B, Anick C, Jean-Paul M, Benoît M, Philippe K, Isabelle M. | 03/5/2022 |
| POLE/POLD1 mutation in non-exonuclease domain matters for predicting efficacy of immune-checkpoint-inhibitor therapy. | POLE/POLD1 mutation in non-exonuclease domain matters for predicting efficacy of immune-checkpoint-inhibitor therapy.
Chen YX, Wang ZX, Yuan SQ, Jiang TJ, Huang YS, Xu RH, Wang F, Zhao Q., Free PMC Article | 02/12/2022 |
| POLD1 Deficiency Reveals a Role for POLD1 in DNA Repair and T and B Cell Development. | POLD1 Deficiency Reveals a Role for POLD1 in DNA Repair and T and B Cell Development.
Nichols-Vinueza DX, Delmonte OM, Bundy V, Bosticardo M, Zimmermann MT, Dsouza NR, Pala F, Dobbs K, Stoddard J, Niemela JE, Kuehn HS, Keller MD, Rueda CM, Abraham RS, Urrutia R, Rosenzweig SD, Notarangelo LD., Free PMC Article | 01/15/2022 |
| Pedigree analysis of a POLD1 germline mutation in urothelial carcinoma shows a close association between different mutation burdens and overall survival. | Pedigree analysis of a POLD1 germline mutation in urothelial carcinoma shows a close association between different mutation burdens and overall survival.
Wang Y, Ju L, Guo Z, Qian K, Chen H, Zhang Y, Xiao Y, Wang X., Free PMC Article | 01/1/2022 |
| Increased somatic mutation burdens in normal human cells due to defective DNA polymerases. | Increased somatic mutation burdens in normal human cells due to defective DNA polymerases.
Robinson PS, Coorens THH, Palles C, Mitchell E, Abascal F, Olafsson S, Lee BCH, Lawson ARJ, Lee-Six H, Moore L, Sanders MA, Hewinson J, Martin L, Pinna CMA, Galavotti S, Rahbari R, Campbell PJ, Martincorena I, Tomlinson I, Stratton MR., Free PMC Article | 11/13/2021 |
| POLD1 variants leading to reduced polymerase activity can cause hearing loss without syndromic features. | POLD1 variants leading to reduced polymerase activity can cause hearing loss without syndromic features.
Oh DY, Matsumoto Y, Kitajiri SI, Kim NKD, Kim MY, Kim AR, Lee M, Lee C, Tomkinson AE, Katsuno T, Kim SY, Shin HW, Han JH, Lee S, Park WY, Choi BY., Free PMC Article | 07/24/2021 |
| Functional analysis of POLD1 p.ser605del variant: the aging phenotype of MDPL syndrome is associated with an impaired DNA repair capacity. | Functional analysis of POLD1 p.ser605del variant: the aging phenotype of MDPL syndrome is associated with an impaired DNA repair capacity.
Murdocca M, Spitalieri P, De Masi C, Udroiu I, Marinaccio J, Sanchez M, Talarico RV, Fiorillo C, D'Adamo M, Sbraccia P, D'Apice MR, Novelli G, Sgura A, Sangiuolo F., Free PMC Article | 07/24/2021 |
| Preliminary study on the function of the POLD1 (CDC2) EXON2 c.56G>A mutation. | Preliminary study on the function of the POLD1 (CDC2) EXON2 c.56G>A mutation.
Liu J, Liu Y, Fu J, Liu C, Yang T, Zhang X, Cao M, Wang P., Free PMC Article | 05/15/2021 |
| POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East. | POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East.
Siraj AK, Bu R, Iqbal K, Parvathareddy SK, Masoodi T, Siraj N, Al-Rasheed M, Kong Y, Ahmed SO, Al-Obaisi KAS, Victoria IG, Arshad M, Al-Dayel F, Abduljabbar A, Ashari LH, Al-Kuraya KS., Free PMC Article | 05/15/2021 |
| Role of POLE and POLD1 in familial cancer. | Role of POLE and POLD1 in familial cancer.
Mur P, García-Mulero S, Del Valle J, Magraner-Pardo L, Vidal A, Pineda M, Cinnirella G, Martín-Ramos E, Pons T, López-Doriga A, Belhadj S, Feliubadaló L, Munoz-Torres PM, Navarro M, Grau E, Darder E, Llort G, Sanz J, Ramón Y Cajal T, Balmana J, Brunet J, Moreno V, Piulats JM, Matías-Guiu X, Sanz-Pamplona R, Aligué R, Capellá G, Lázaro C, Valle L., Free PMC Article | 05/8/2021 |
| Dynamic Assembly and Disassembly of the Human DNA Polymerase delta Holoenzyme on the Genome In Vivo. | Dynamic Assembly and Disassembly of the Human DNA Polymerase δ Holoenzyme on the Genome In Vivo.
Drosopoulos WC, Vierra DA, Kenworthy CA, Coleman RA, Schildkraut CL., Free PMC Article | 03/20/2021 |