| P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia. | P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia.
Wang N, Su X, Sams D, Prabhakar NR, Nanduri J., | 02/5/2024 |
| CREB-binding protein and HIF-1alpha/beta-catenin to upregulate miR-322 and alleviate myocardial ischemia-reperfusion injury. | CREB-binding protein and HIF-1α/β-catenin to upregulate miR-322 and alleviate myocardial ischemia-reperfusion injury.
Dong W, Weng JF, Zhu JB, Zheng YF, Liu LL, Dong C, Ruan Y, Fang X, Chen J, Liu WY, Peng XP, Chen XY. | 08/17/2023 |
| CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory. | CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory.
Barker GR, Wong LF, Uney JB, Warburton EC., Free PMC Article | 05/1/2021 |
| The data suggest that alterations of histone H3 acetylation in the preoptic area and anteroventral periventricular nucleus and the inability of Ncoa2 and Crebbp to respond to estradiol in the middle-aged anterior hypothalamus partially contribute to the decline of GnRH neuron activation and estradiol target gene expression changes that occur in females along with reproductive aging. | Alterations of estradiol-induced histone H3 acetylation in the preoptic area and anteroventral periventricular nucleus of middle-aged female rats.
Xu W, Huang J, Li L, Zhang X, Wang Y, Tong G, Sun Y. | 07/11/2020 |
| This study showed an anti-silicotic effect of db-cAMP that was mediated via PKA/p-CREB/CBP signaling. Furthermore, the findings offer novel insight into the potential use of cAMP signaling for therapeutic strategies to treat silicosis. | Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis.
Liu Y, Xu H, Geng Y, Xu D, Zhang L, Yang Y, Wei Z, Zhang B, Li S, Gao X, Wang R, Zhang X, Brann D, Yang F., Free PMC Article | 12/2/2017 |
| Data indicate that combined treatment of insulin and selenium suppresses cardiomyocyte apoptosis by inhibiting p38-mitogen-activated protein kinase/CREB-binding protein (p38MAPK/CBP) pathway. | [Insulin combined with selenium inhibit p38MAPK/CBP pathway and suppresses cardiomyocyte apoptosis in rats with diabetic cardiomyopathy].
Xu T, Liu Y, Deng Y, Meng J, Li P, Xu X, Zeng J. | 01/14/2017 |
| the fast transient expression of Bdnf promoters II and VI after neuronal stimulation is dependent on acetylation of histone H3K27 by CREB-p/CBP. | Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons.
Palomer E, Carretero J, Benvegnù S, Dotti CG, Martin MG., Free PMC Article | 09/3/2016 |
| EP2/cAMP/protein kinase A pathway mediates the stimulatory effect of PGEs on angiogenesis essential for tissue injury healing via the induction of CREB activity and VEGF expression. | Novel mechanisms and signaling pathways of esophageal ulcer healing: the role of prostaglandin EP2 receptors, cAMP, and pCREB.
Ahluwalia A, Baatar D, Jones MK, Tarnawski AS., Free PMC Article | 11/8/2014 |
| miR-22 could inhibit apoptosis of cardiomyocytes through one of its targets, CBP. | MicroRNA-22 targeting CBP protects against myocardial ischemia-reperfusion injury through anti-apoptosis in rats.
Yang J, Chen L, Yang J, Ding J, Li S, Wu H, Zhang J, Fan Z, Dong W, Li X. | 08/30/2014 |
| p300 and CBP are probably involved in the maintenance of neuropathic pain on spinal cord level. | Temporal distribution of p300/CBP immunoreactivity in the adult rat spinal dorsal horn following chronic constriction injury (CCI).
Zhu XY, Huang CS, Li Q, Guo QL, Wang Y, He X, Liao J. | 08/10/2013 |
| Hippocampal CBP levels were equivalent as a function of age and cognitive status in young, unimpaired aged, and impaired aged rats. | CREB-binding protein levels in the rat hippocampus fail to predict chronological or cognitive aging.
Tomás Pereira I, Coletta CE, Perez EV, Kim DH, Gallagher M, Goldberg IG, Rapp PR., Free PMC Article | 05/25/2013 |
| CBP may be one of the main interaction targets for Egr-1, transient activation of Egr-1 and recruitment of CBP are required for thrombin-induced PDGF-B production in endothelial cells. | Transcriptional regulation of platelet-derived growth factor-B chain by thrombin in endothelial cells: involvement of Egr-1 and CREB-binding protein.
Chen J, Xu L, Chen S, Yang J, Jiang H. | 10/13/2012 |
| CBP plays an important role in thrombin-induced endothelial progenitor cell neovascularization. | CREB-binding protein silencing inhibits thrombin-induced endothelial progenitor cells angiogenesis.
Jiang H, Chen SS, Yang J, Chen J, He B, Zhu LH, Wang L. | 05/26/2012 |
| Nocturnal changes in protein complexes at the Rgs4 AP-1R sequence are associated with FRA-2-dependent dismissal of the co-activator, CBP; this provides a mechanistic basis for Rgs4 gene repression | Selective genomic targeting by FRA-2/FOSL2 transcription factor: regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/CREB-binding protein (CBP) mechanism.
Davies JS, Klein DC, Carter DA., Free PMC Article | 07/16/2011 |
| Silencing CBP expression also suppressed thrombin-induced PDGF-B expression in endothelial cells. | Down-regulation of CREB-binding protein expression inhibits thrombin-induced proliferation of endothelial cells: possible relevance to PDGF-B.
Jiang H, Chen J, Wang L, Zhu LH, Wen HZ. | 02/26/2011 |
| CBP/p300 and P/CAF are key players in neuronal outgrowth, acetylate histone H3 at K9-14 and the transcription factor p53, thereby initiating a pro-neuronal outgrowth transcriptional program. | HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation.
Gaub P, Tedeschi A, Puttagunta R, Nguyen T, Schmandke A, Di Giovanni S. | 01/15/2011 |
| CBP gene silencing significantly inhibits Ang II-induced vascular smooth muscle cell proliferation through down-regulation NF-kB transcriptional activity, rather than a change in DNA binding or nuclear translocation. | CBP knockdown inhibits angiotensin II-induced vascular smooth muscle cells proliferation through downregulating NF-kB transcriptional activity.
Yang J, Jiang H, Chen SS, Chen J, Xu SK, Li WQ, Wang JC. | 09/27/2010 |
| CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein | CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein (CBP).
Lee S, Miller M, Shuman JD, Johnson PF., Free PMC Article | 08/16/2010 |
| Developmental ID and hypothyroidism down-regulate hippocampal ERK1/2 and CREB in lactational and adolescent rats. | Developmental iodine deficiency resulting in hypothyroidism reduces hippocampal ERK1/2 and CREB in lactational and adolescent rats.
Dong J, Liu W, Wang Y, Hou Y, Xi Q, Chen J., Free PMC Article | 02/15/2010 |
| p300 is essential for the maintenance of mitochondrial integrity and for myocyte survival in the postnatal left ventricular myocardium. | p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.
Nakagawa Y, Kuwahara K, Takemura G, Akao M, Kato M, Arai Y, Takano M, Harada M, Murakami M, Nakanishi M, Usami S, Yasuno S, Kinoshita H, Fujiwara M, Ueshima K, Nakao K. | 01/21/2010 |
| cAMP and glucose signaling converge on a complex containing ChREBP, HNF4alpha, and CBP, and cAMP acts by disrupting this transcriptional complex assembled by glucose-derived signals | cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4alpha, and CBP.
Burke SJ, Collier JJ, Scott DK. | 01/21/2010 |
| Data demonstrate that beraprost (BPS)-mediated PPARdelta activation enhances transcriptional activation of p21/p27 by increasing CBP nuclear translocation, which contributes to the vasoprotective action of BPS. | PPARdelta-mediated p21/p27 induction via increased CREB-binding protein nuclear translocation in beraprost-induced antiproliferation of murine aortic smooth muscle cells.
Sue YM, Chung CP, Lin H, Chou Y, Jen CY, Li HF, Chang CC, Juan SH. | 01/21/2010 |
| induction of CBP by TNF-alpha was observed only in neurons, but not in astroglia and microglia, and it was contingent on the activation of transcription factor NF-kappaB. | TNF-alpha preconditioning protects neurons via neuron-specific up-regulation of CREB-binding protein.
Saha RN, Ghosh A, Palencia CA, Fung YK, Dudek SM, Pahan K., Free PMC Article | 01/21/2010 |
| These findings suggest that CBP plays a pivotal role in the S phase progression of vascular smooth muscle cells. | Dysregulation of CREB binding protein triggers thrombin-induced proliferation of vascular smooth muscle cells.
Chen J, Jiang H, Xu L, Zhu LH, Wang L, Wen HZ, Hu XR. | 01/21/2010 |
| Oxymatrine could promote the expression of Smad 7 and inhibit the expression of Smad 3 and CBP in CCl4-induced hepatic fibrosis in SD rats, and could modulate the fibrogenic signal transduction of TGFbeta-Smad pathway | Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis.
Wu XL, Zeng WZ, Jiang MD, Qin JP, Xu H., Free PMC Article | 01/21/2010 |