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    POLR2E RNA polymerase II, I and III subunit E [ Homo sapiens (human) ]

    Gene ID: 5434, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Our results indicated that the rs3787016 polymorphism in polymerase II polypeptide E was associated with the risk of both breast cancer and cervical cancer

    The POLR2E rs3787016 polymorphism is strongly associated with the risk of female breast and cervical cancer.
    Chen B, Jiao Y, Yaolong F, Li T, Liu Y, Wang M, Xiuli G, Feng X.

    08/31/2019
    we here conducted a case-control study to investigate the association of POLR2E rs3787016 polymorphism with risk of liver and lung cancer..Although no significant association was found for rs3787016 with risk of liver or lung cancer, the further stratified analysis identified that rs3787016 contributed to liver cancer risk particularly for over than 60 years individuals who drink

    The association of POLR2E rs3787016 polymorphism and cancer risk: a Chinese case-control study and meta-analysis.
    Chen B, Wang S, Ma G, Han J, Zhang J, Gu X, Feng X., Free PMC Article

    07/27/2019
    rs3787016 T/rs1046040 C significantly increased the risk of prostate cancer compared to C/C (p = 0.037

    Long non-coding RNA POLR2E gene polymorphisms increased the risk of prostate cancer in a sample of the Iranian population.
    Sattarifard H, Hashemi M, Hassanzarei S, Basiri A, Narouie B, Ghavami S.

    06/22/2019
    POLR2E rs3787016T allele was associated with an increased cancer risk in Chinese population

    Long non-coding RNA POLR2E rs3787016 is associated with the risk of papillary thyroid carcinoma in Chinese population.
    Chen B, Li J, Yi C, Jiao Y, Gu X, Feng X.

    10/27/2018
    POLR2E rs3787016 C/T and HULC rs7763881 were associated with a significantly decreased risk for ESCC 0.005). ANRIL rs2151280 T/C SNP was not associated with risk of ESCC.

    Long noncoding RNAs POLR2E rs3787016 C/T and HULC rs7763881 A/C polymorphisms are associated with decreased risk of esophageal cancer.
    Kang M, Sang Y, Gu H, Zheng L, Wang L, Liu C, Shi Y, Shao A, Ding G, Chen S, Tang W, Yin J.

    11/21/2015
    ELL has an early and essential role during rapid high-amplitude gene expression that is required for both Pol II pause site entry and release

    ELL facilitates RNA polymerase II pause site entry and release.
    Byun JS, Fufa TD, Wakano C, Fernandez A, Haggerty CM, Sung MH, Gardner K., Free PMC Article

    07/28/2012
    crystal of RPB5 diffracted to 2.8 A resolution and belonged to space group P4(3)2(1)2.

    Crystallization and preliminary X-ray analysis of the RPB5 subunit of human RNA polymerase II.
    Ye X, Xiao P, Hu X, Chen Y, Zhang L, Xie W, Hu X., Free PMC Article

    02/25/2012
    RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells.

    RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells.
    Yang H, Gu J, Zheng Q, Li M, Lian X, Miao J, Jiang J, Wei W., Free PMC Article

    06/4/2011
    Observational study of gene-disease association. (HuGE Navigator)

    Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
    Hosgood HD 3rd, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q., Free PMC Article

    12/2/2009
    Is part of an RNA polymerase II-associated complex with possible chaperone activity.

    High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes.
    Cloutier P, Al-Khoury R, Lavallée-Adam M, Faubert D, Jiang H, Poitras C, Bouchard A, Forget D, Blanchette M, Coulombe B., Free PMC Article

    11/5/2009
    Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)

    Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.
    Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Méjean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S.

    03/25/2009
    Results pinpoint critical residues for RNA polymerase II subunit 5 binding to RAP30 and/or to HBx, and identify these residues in both mammalian cells and in an in vitro binding assay.

    Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein.
    Le TT, Zhang S, Hayashi N, Yasukawa M, Delgermaa L, Murakami S.

    01/21/2010
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