| WNT4 (rs7521902 and rs16826658) polymorphism and its association with endometriosis - A systematic review and meta-analysis. | WNT4 (rs7521902 and rs16826658) polymorphism and its association with endometriosis - A systematic review and meta-analysis.
Meidyana S, Isfandiary S, Primariawan RY. | 03/29/2024 |
| WNT4 promotes macrophage polarization via granulosa cell M-CSF and reduces granulosa cell apoptosis in endometriosis. | WNT4 promotes macrophage polarization via granulosa cell M-CSF and reduces granulosa cell apoptosis in endometriosis.
Yuan Y, Li Y, Zhao W, Hu Y, Zhou C, Long T, Long L. | 03/18/2024 |
| WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers. | WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers.
Sottnik JL, Shackleford MT, Robinson SK, Villagomez FR, Bahnassy S, Oesterreich S, Hu J, Madak-Erdogan Z, Riggins RB, Corr BR, Cook LS, Treviño LS, Bitler BG, Sikora MJ., Free PMC Article | 01/29/2024 |
| Mutation analysis of WNT4 gene in SRY negative 46,XX DSD patients with Mullerian agenesis and/or gonadal dysgenesis- An Indian study. | Mutation analysis of WNT4 gene in SRY negative 46,XX DSD patients with Mullerian agenesis and/or gonadal dysgenesis- An Indian study.
Ragitha TS, Sunish KS, Gilvaz S, Daniel S, Varghese PR, Raj S, Francis J, Suresh Kumar R. | 02/28/2023 |
| Serum WNT4 protein as an indicator of chronic glomerulonephritis but not a marker of inflammatory cell infiltration and fibrosis: A preliminary study. | Serum WNT4 protein as an indicator of chronic glomerulonephritis but not a marker of inflammatory cell infiltration and fibrosis: A preliminary study.
Kiewisz J, Pawłowska A, Winiarska A, Perkowska-Ptasińska A, Skowrońska A, Godlewski J, Kmieć Z, Stompór T. | 07/16/2022 |
| Wnt4, Wnt6 and beta-catenin expression in human placental tissue - is there a link with first trimester miscarriage? Results from a pilot study. | Wnt4, Wnt6 and β-catenin expression in human placental tissue - is there a link with first trimester miscarriage? Results from a pilot study.
Chronopoulou E, Koika V, Tsiveriotis K, Stefanidis K, Kalogeropoulos S, Georgopoulos N, Adonakis G, Kaponis A., Free PMC Article | 04/2/2022 |
| A circular RNA, circUSP36, accelerates endothelial cell dysfunction in atherosclerosis by adsorbing miR-637 to enhance WNT4 expression. | A circular RNA, circUSP36, accelerates endothelial cell dysfunction in atherosclerosis by adsorbing miR-637 to enhance WNT4 expression.
Huang JG, Tang X, Wang JJ, Liu J, Chen P, Sun Y., Free PMC Article | 01/22/2022 |
| Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus. | Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus.
Kho PF, Mortlock S, Endometrial Cancer Association Consortium, International Endometriosis Genetics Consortium, Rogers PAW, Nyholt DR, Montgomery GW, Spurdle AB, Glubb DM, O'Mara TA. | 08/14/2021 |
| WNT4 secreted by tumor tissues promotes tumor progression in colorectal cancer by activation of the Wnt/beta-catenin signalling pathway. | WNT4 secreted by tumor tissues promotes tumor progression in colorectal cancer by activation of the Wnt/β-catenin signalling pathway.
Yang D, Li Q, Shang R, Yao L, Wu L, Zhang M, Zhang L, Xu M, Lu Z, Zhou J, Huang L, Huang X, Cheng D, Yang Y, Yu H., Free PMC Article | 07/31/2021 |
| Analysis of copy number variations of WNT4 gene in a Chinese population with Mullerian anomalies. | Analysis of copy number variations of WNT4 gene in a Chinese population with Müllerian anomalies.
Zhu Y, Wang R, Cheng Y, Han Y, Li T, Cao Y, Wang B., Free PMC Article | 07/24/2021 |
| Activation of protein kinase B by WNT4 as a regulator of uterine leiomyoma stem cell function. | Activation of protein kinase B by WNT4 as a regulator of uterine leiomyoma stem cell function.
Liu S, Yin P, Dotts AJ, Kujawa SA, Coon V JS, Wei JJ, Chakravarti D, Bulun SE., Free PMC Article | 05/29/2021 |
| Introduction of Somatic Mutation in MED12 Induces Wnt4/beta-Catenin and Disrupts Autophagy in Human Uterine Myometrial Cell. | Introduction of Somatic Mutation in MED12 Induces Wnt4/β-Catenin and Disrupts Autophagy in Human Uterine Myometrial Cell.
El Andaloussi A, Al-Hendy A, Ismail N, Boyer TG, Halder SK., Free PMC Article | 12/12/2020 |
| Wnt4 negatively regulates the TGF-beta1-induced human dermal fibroblast-to-myofibroblast transition via targeting Smad3 and ERK. | Wnt4 negatively regulates the TGF-β1-induced human dermal fibroblast-to-myofibroblast transition via targeting Smad3 and ERK.
Liu J, Zhao B, Zhu H, Pan Q, Cai M, Bai X, Li X, Hu X, Zhang M, Shi J, Zheng Z, Yang A, Hu D. | 10/24/2020 |
| Parathyroid hormone can affect the osteogenesis process of adipose tissue stem cells by regulating SIK2 and Wnt4. | Parathyroid hormone (PTH) promotes ADSC osteogenesis by regulating SIK2 and Wnt4.
An Y, Zhao J, Nie F, Wu Y, Xia Y, Li D. | 07/4/2020 |
| TNF-alpha significantly suppressed calcium deposition in human BMSCs. Wnt4 expression was successfully down-regulated with siRNA. Calcium deposition was significantly decreased in the cells pretreated with Wnt4 siRNA under melatonin stimulation. | Wnt4 signaling mediates protective effects of melatonin on new bone formation in an inflammatory environment.
Li X, Li Z, Wang J, Li Z, Cui H, Dai G, Chen S, Zhang M, Zheng Z, Zhan Z, Liu H. | 06/6/2020 |
| altered WNT4 gene expression in patients with different types of glomerular diseases and patients at different stages of CKD may play a role in kidney tissue disorganization as well as disease development and progression | WNT4 Expression in Primary and Secondary Kidney Diseases: Dependence on Staging.
Kiewisz J, Skowronska A, Winiarska A, Pawlowska A, Kiezun J, Rozicka A, Perkowska-Ptasinska A, Kmiec Z, Stompor T. | 12/21/2019 |
| Study of cisplatin-induced acute kidney injury (AKI) model in rats and clinical study of contrast agent induced AKI is the first to demonstrate that increased expression of renal and urinary Wnt4 can be detected earlier than serum creatinine after drug-induced AKI suggesting that urinary Wnt4 can potentially serve as a noninvasive biomarker for monitoring patients with tubular injury. | Wnt4 is significantly upregulated during the early phases of cisplatin-induced acute kidney injury.
He YX, Diao TT, Song SM, Wang CC, Wang Y, Zhou CL, Bai YB, Yu SS, Mi X, Yang XY, Wei QJ, Li B., Free PMC Article | 11/30/2019 |
| results show that the WNT4 gene is associated with epithelial ovarian cancer risk | Relationship of WNT4 Gene with the Risk of Epithelial Ovarian Cancer: A Han Chinese Population-Based Association Study.
Zhang J, Zhang P, Shen Y, Yang M, Zou H, Liu H. | 01/5/2019 |
| Annotation of rs2072920 in WNT4 in tissues might be related to obesity. | SNP-SNP interactions between WNT4 and WNT5A were associated with obesity related traits in Han Chinese Population.
Dong SS, Hu WX, Yang TL, Chen XF, Yan H, Chen XD, Tan LJ, Tian Q, Deng HW, Guo Y., Free PMC Article | 11/17/2018 |
| We found a genetic association between rs11031006 (FSHB) SNP and endometriosis. WNT4 and VEZT genes constitute the most consistently associated genes with endometriosis. In the present study, an association of rs7521902 (WNT4) and rs10859871 (VEZT) was confirmed in women with endometriosis at the genotypic but not the allelic level. | The role of gene polymorphisms in endometriosis.
Matalliotakis M, Zervou MI, Matalliotaki C, Rahmioglu N, Koumantakis G, Kalogiannidis I, Prapas I, Zondervan K, Spandidos DA, Matalliotakis I, Goulielmos GN., Free PMC Article | 07/28/2018 |
| urinary Wnt4 could be a potential noninvasive biomarker for the early detection of tubular injury. | Wnt4 is a novel biomarker for the early detection of kidney tubular injury after ischemia/reperfusion injury.
Zhao SL, Wei SY, Wang YX, Diao TT, Li JS, He YX, Yu J, Jiang XY, Cao Y, Mao XY, Wei QJ, Wang Y, Li B., Free PMC Article | 05/26/2018 |
| were not able to replicate or further verify the genetic association of polymorphisms in WNT4 and WNT5B with bone mineral density | Genetic Screening of WNT4 and WNT5B in Two Populations with Deviating Bone Mineral Densities.
Hendrickx G, Boudin E, Steenackers E, Nielsen TL, Andersen M, Brixen K, Van Hul W. | 02/3/2018 |
| These findings demonstrate that autocrine human growth hormone regulates WNT4 expression and that WNT4 is a potential therapeutic target in human breast cancer. | WNT4 mediates the autocrine effects of growth hormone in mammary carcinoma cells.
Vouyovitch CM, Perry JK, Liu DX, Bezin L, Vilain E, Diaz JJ, Lobie PE, Mertani HC. | 01/6/2018 |
| WNT4 encodes wingless-type MMTV integration site family member 4. WNT4 mutations have been found in women with mullerian duct abnormalities, primary amenorrhea, and hyperandrogenism and common variants in WNT4, which are in high linkage disequilibrium with our index SNPs, are associated with endometriosis, ovarian cancer,and bone mineral density of WNT4, and the T allele generates a strong ESR1-binding site. | Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.
Zhang G, Feenstra B, Bacelis J, Liu X, Muglia LM, Juodakis J, Miller DE, Litterman N, Jiang PP, Russell L, Hinds DA, Hu Y, Weirauch MT, Chen X, Chavan AR, Wagner GP, Pavličev M, Nnamani MC, Maziarz J, Karjalainen MK, Rämet M, Sengpiel V, Geller F, Boyd HA, Palotie A, Momany A, Bedell B, Ryckman KK, Huusko JM, Forney CR, Kottyan LC, Hallman M, Teramo K, Nohr EA, Davey Smith G, Melbye M, Jacobsson B, Muglia LJ., Free PMC Article | 10/24/2017 |
| Our MRKH families included 43 quads, 26 trios, and 30 duos. Of our MRKH probands, 87/147 (59%) had MRKH type 1 and 60/147 (41%) had type 2 with additional anomalies. CONCLUSION(S): Although the prevalence of WNT4, HNF1B, and LHX1 point mutations is low in people with MRKH, the prevalence of CNVs was approximately 19%. | Genetic analysis of Mayer-Rokitansky-Kuster-Hauser syndrome in a large cohort of families.
Williams LS, Demir Eksi D, Shen Y, Lossie AC, Chorich LP, Sullivan ME, Phillips JA 3rd, Erman M, Kim HG, Alper OM, Layman LC., Free PMC Article | 08/19/2017 |