| The requirement of mitochondrial RNA polymerase for non-small cell lung cancer cell growth. | The requirement of mitochondrial RNA polymerase for non-small cell lung cancer cell growth.
Zhou T, Sang YH, Cai S, Xu C, Shi MH., Free PMC Article | 01/29/2022 |
| TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication. | TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication.
Inatomi T, Matsuda S, Ishiuchi T, Do Y, Nakayama M, Abe S, Kasho K, Wanrooij S, Nakada K, Ichiyanagi K, Sasaki H, Yasukawa T, Kang D. | 01/1/2022 |
| POLRMT mutations impair mitochondrial transcription causing neurological disease. | POLRMT mutations impair mitochondrial transcription causing neurological disease.
Oláhová M, Peter B, Szilagyi Z, Diaz-Maldonado H, Singh M, Sommerville EW, Blakely EL, Collier JJ, Hoberg E, Stránecký V, Hartmannová H, Bleyer AJ, McBride KL, Bowden SA, Korandová Z, Pecinová A, Ropers HH, Kahrizi K, Najmabadi H, Tarnopolsky MA, Brady LI, Weaver KN, Prada CE, Õunap K, Wojcik MH, Pajusalu S, Syeda SB, Pais L, Estrella EA, Bruels CC, Kunkel LM, Kang PB, Bonnen PE, Mráček T, Kmoch S, Gorman GS, Falkenberg M, Gustafsson CM, Taylor RW., Free PMC Article | 04/3/2021 |
| the frequency of variation in sequence identity and length at conserved sequence block 2 amongst human mitochondrial genomes and used in vitro transcription to assess the effects of this length heterogeneity on the activity of the mitochondrial RNA polymerase, POLRMT, was examined. | Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity.
Tan BG, Wellesley FC, Savery NJ, Szczelkun MD., Free PMC Article | 06/24/2017 |
| Suggest targeting POLRMT as strategy for treating acute myeloid leukemia. | Targeting mitochondrial RNA polymerase in acute myeloid leukemia.
Bralha FN, Liyanage SU, Hurren R, Wang X, Son MH, Fung TA, Chingcuanco FB, Tung AY, Andreazza AC, Psarianos P, Schimmer AD, Salmena L, Laposa RR., Free PMC Article | 09/10/2016 |
| knock-down of MRPL12 by RNA interference results in instability of POLRMT. | Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during Import.
Nouws J, Goswami AV, Bestwick M, McCann BJ, Surovtseva YV, Shadel GS., Free PMC Article | 05/21/2016 |
| Results show that polymorphisms at POLG2 and POLRMT increased risk of oral cancer and leukoplakia, respectively, probably modulating synthesis and activity of the enzymes. | Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer.
Datta S, Ray A, Roy R, Roy B. | 03/19/2016 |
| The results reveal the organization of TFAM, POLRMT and TFB2M around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex. | Organization of the human mitochondrial transcription initiation complex.
Yakubovskaya E, Guja KE, Eng ET, Choi WS, Mejia E, Beglov D, Lukin M, Kozakov D, Garcia-Diaz M., Free PMC Article | 06/28/2014 |
| The results demonstrate that human TFAM binds to the N-terminal domain of mtRNAP, which results in bending of the promoter DNA around mtRNAP. | A novel intermediate in transcription initiation by human mitochondrial RNA polymerase.
Morozov YI, Agaronyan K, Cheung AC, Anikin M, Cramer P, Temiakov D., Free PMC Article | 06/28/2014 |
| Newly synthesized RNA exits toward the pentatricopeptide repeat (PPR) domain, a unique feature of mtRNAP with conserved RNA-recognition motifs. | Structure of human mitochondrial RNA polymerase elongation complex.
Schwinghammer K, Cheung AC, Morozov YI, Agaronyan K, Temiakov D, Cramer P., Free PMC Article | 01/4/2014 |
| Authors propose that POLRMT interacts directly with h-mtTFB1 in 28S mitochondrial ribosomes to augment its 12S rRNA methyltransferase activity. | Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis.
Surovtseva YV, Shadel GS., Free PMC Article | 05/11/2013 |
| X-ray structure of human mtRNAP at 2.5 A resolution, which reveals a T7-like catalytic carboxy-terminal domain, an amino-terminal domain resembling the T7 promoter-binding domain, a novel pentatricopeptide repeat domain, and flexible N-terminal extension | Structure of human mitochondrial RNA polymerase.
Ringel R, Sologub M, Morozov YI, Litonin D, Cramer P, Temiakov D. | 01/28/2012 |
| muscle actin genes are transcribed by nuclear isoform of mitochondrial RNA polymerase (spRNAP-IV) whereas the non-muscle actin genes are transcribed by the conventional RNA polymerase II (PolII) | Transcription of muscle actin genes by a nuclear form of mitochondrial RNA polymerase.
Lee YL, Chiao CH, Hsu MT., Free PMC Article | 12/10/2011 |
| Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds | Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds.
Smidansky ED, Arnold JJ, Reynolds SL, Cameron CE., Free PMC Article | 08/13/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| POLRMT can function as an origin-specific primase in mammalian mitochondria. | Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication.
Fusté JM, Wanrooij S, Jemt E, Granycome CE, Cluett TJ, Shi Y, Atanassova N, Holt IJ, Gustafsson CM, Falkenberg M. | 03/8/2010 |
| Promoter-independent DNA conformation-dependent transcription required TFB2M and was suppressed by TFAM, while promoter-dependent transcription was inhibited to a lesser extent BY TFAM. | DNA conformation-dependent activities of human mitochondrial RNA polymerase.
Fukuoh A, Ohgaki K, Hatae H, Kuraoka I, Aoki Y, Uchiumi T, Jacobs HT, Kang D. | 01/21/2010 |
| Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) | Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.
Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Méjean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S. | 03/25/2009 |
| transcription of some mRNAs in humans and rodents is mediated by a previously unknown single-polypeptide nuclear RNA polymerase (spRNAP-IV), expressed from an alternative transcript of the mitochondrial RNA polymerase gene POLRMT | Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin.
Kravchenko JE, Rogozin IB, Koonin EV, Chumakov PM., Free PMC Article | 01/21/2010 |
| human mitochondrial DNA polymerase has a role in autosomal dominant progressive external ophthalmoplegia | Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia.
Graziewicz MA, Longley MJ, Bienstock RJ, Zeviani M, Copeland WC. | 01/21/2010 |
| POLRMT recognizes promoter elements in a sequence specific manner; TFAM induces a structural change of the promoter that is required for POLRMT-dependent promoter recognition | The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells.
Gaspari M, Falkenberg M, Larsson NG, Gustafsson CM., Free PMC Article | 01/21/2010 |
| the MRPL12 interaction with POLRMT is likely part of a novel regulatory mechanism that coordinates mitochondrial transcription with translation | Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression.
Wang Z, Cotney J, Shadel GS., Free PMC Article | 01/21/2010 |