| Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages. | Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages.
Sun R, Lei C, Xu Z, Gu X, Huang L, Chen L, Tan Y, Peng M, Yaddanapudi K, Siskind L, Kong M, Mitchell R, Yan J, Deng Z., Free PMC Article | 02/12/2024 |
| Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection. | Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection.
Sun R, Gu X, Lei C, Chen L, Chu S, Xu G, Doll MA, Tan Y, Feng W, Siskind L, McClain CJ, Deng Z., Free PMC Article | 04/9/2022 |
| Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis. | Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.
Zhu H, Klement JD, Lu C, Redd PS, Yang D, Smith AD, Poschel DB, Zou J, Liu D, Wang PG, Ostrov D, Coant N, Hannun YA, Colby AH, Grinstaff MW, Liu K., Free PMC Article | 08/7/2021 |
| These results suggest that neutral ceramidase is a mediator of necroptosis and might be a novel therapeutic target for protection from ischaemic injury. | Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.
Sundaram K, Mather AR, Marimuthu S, Shah PP, Snider AJ, Obeid LM, Hannun YA, Beverly LJ, Siskind LJ., Free PMC Article | 08/13/2016 |
| Knocking down NCDase reduced sphingosine accumulation in mitochondria and preserved COX activity after the brain injury. | Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
Novgorodov SA, Riley CL, Yu J, Borg KT, Hannun YA, Proia RL, Kindy MS, Gudz TI., Free PMC Article | 06/28/2014 |
| Neutral ceramidase deficiency increases inflammation in a mouse model of inflammatory bowel disease. | Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.
Snider AJ, Wu BX, Jenkins RW, Sticca JA, Kawamori T, Hannun YA, Obeid LM., Free PMC Article | 04/20/2013 |
| Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. | Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.
Novgorodov SA, Wu BX, Gudz TI, Bielawski J, Ovchinnikova TV, Hannun YA, Obeid LM., Free PMC Article | 01/28/2012 |
| the predicted HNF-4alpha binding site identified in the Asah2 promoter is functional | Identification of a functional hepatocyte nuclear factor 4 binding site in the neutral ceramidase promoter.
Maltesen HR, Troelsen JT, Olsen J. | 04/2/2011 |
| This enzyme is decreased in the small intestine in CFTR transgenic mice with a deletion in CFTR> | Expression of intestinal and lung alkaline sphingomyelinase and neutral ceramidase in cystic fibrosis f508del transgenic mice.
Ohlsson L, Hjelte L, Hühn M, Scholte BJ, Wilke M, Flodström-Tullberg M, Nilsson A. | 01/21/2010 |
| Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1. | Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1.
Romiti E, Meacci E, Donati C, Formigli L, Zecchi-Orlandini S, Farnararo M, Ito M, Bruni P. | 01/21/2010 |
| molecular cloning of the mouse neutral ceramidase gene and its promoter analysis | Genomic structure and promoter analysis of the mouse neutral ceramidase gene.
Okino N, Mori K, Ito M. | 01/21/2010 |
| the Asah2-encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract | Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.
Kono M, Dreier JL, Ellis JM, Allende ML, Kalkofen DN, Sanders KM, Bielawski J, Bielawska A, Hannun YA, Proia RL. | 01/21/2010 |