| Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain. | Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain.
Burris-Hiday SD, Scott EE., Free PMC Article | 11/1/2023 |
| Single Mutations in Cytochrome P450 Oxidoreductase Can Alter the Specificity of Human Cytochrome P450 1A2-Mediated Caffeine Metabolism. | Single Mutations in Cytochrome P450 Oxidoreductase Can Alter the Specificity of Human Cytochrome P450 1A2-Mediated Caffeine Metabolism.
Esteves F, Almeida CMM, Silva S, Saldanha I, Urban P, Rueff J, Pompon D, Truan G, Kranendonk M., Free PMC Article | 08/2/2023 |
| Effect of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of rivaroxaban and edoxaban in patients with nonvalvular atrial fibrillation. | Effect of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of rivaroxaban and edoxaban in patients with nonvalvular atrial fibrillation.
Nakagawa J, Kinjo T, Aiuchi N, Ueno K, Tomita H, Niioka T. | 04/19/2023 |
| POR overexpression induces tamoxifen-resistance in breast cancer through the STAT1/c-Myc pathway. | POR overexpression induces tamoxifen-resistance in breast cancer through the STAT1/c-Myc pathway.
Chen S, Wu D, Liu Q, Jin F, Yao F, Fang Y. | 01/28/2023 |
| In Silico Analysis of PORD Mutations on the 3D Structure of P450 Oxidoreductase. | In Silico Analysis of PORD Mutations on the 3D Structure of P450 Oxidoreductase.
Nurhafizuddin M, Azizi A, Ming LC, Shafqat N., Free PMC Article | 07/30/2022 |
| The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics. | The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics.
Fang Y, Yang H, Hu G, Lu J, Zhou J, Gao N, Gu Y, Zhang C, Qiu J, Guo Y, Zhang Y, Wen Q, Qiao H., Free PMC Article | 03/26/2022 |
| Cytochrome P450 reductase (POR) as a ferroptosis fuel. | Cytochrome P450 reductase (POR) as a ferroptosis fuel.
Koppula P, Zhuang L, Gan B., Free PMC Article | 01/29/2022 |
| POR polymorphisms are associated with 21 hydroxylase deficiency. | POR polymorphisms are associated with 21 hydroxylase deficiency.
Pecori Giraldi F, Einaudi S, Sesta A, Verna F, Messina M, Manieri C, Menegatti E, Ghizzoni L., Free PMC Article | 01/22/2022 |
| Stereoselective Bupropion Hydroxylation by Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase Genetic Variants. | Stereoselective Bupropion Hydroxylation by Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase Genetic Variants.
Wang PF, Neiner A, Kharasch ED., Free PMC Article | 07/24/2021 |
| Microsomal reductase activity in patients with thyroid neoplasms. | Microsomal reductase activity in patients with thyroid neoplasms.
Proskurnina EV, Fedorova MV, Sozarukova MM, Mitichkin AE, Panteleev IV, Svetlov EV. | 07/17/2021 |
| An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase. | An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase.
Mukherjee G, Nandekar PP, Wade RC., Free PMC Article | 07/3/2021 |
| Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis. | Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis.
Meguro A, Ishihara M, Petrek M, Yamamoto K, Takeuchi M, Mrazek F, Kolek V, Benicka A, Yamane T, Shibuya E, Yoshino A, Isomoto A, Ota M, Yatsu K, Shijubo N, Nagai S, Yamaguchi E, Yamaguchi T, Namba K, Kaburaki T, Takase H, Morimoto SI, Hori J, Kono K, Goto H, Suda T, Ikushima S, Ando Y, Takenaka S, Takeuchi M, Yuasa T, Sugisaki K, Ohguro N, Hiraoka M, Kitaichi N, Sugiyama Y, Horita N, Asukata Y, Kawagoe T, Kimura I, Ishido M, Inoko H, Mochizuki M, Ohno S, Bahram S, Remmers EF, Kastner DL, Mizuki N., Free PMC Article | 06/26/2021 |
| Clinical and genetic analysis of cytochrome P450 oxidoreductase (POR) deficiency in a female and the analysis of a novel POR intron mutation causing alternative mRNA splicing : Overall analysis of a female with POR deficiency. | Clinical and genetic analysis of cytochrome P450 oxidoreductase (POR) deficiency in a female and the analysis of a novel POR intron mutation causing alternative mRNA splicing : Overall analysis of a female with POR deficiency.
Zhang T, Li Z, Ren X, Huang B, Zhu G, Yang W, Jin L., Free PMC Article | 05/29/2021 |
| Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase. | Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase.
Jensen SB, Thodberg S, Parween S, Moses ME, Hansen CC, Thomsen J, Sletfjerding MB, Knudsen C, Del Giudice R, Lund PM, Castaño PR, Bustamante YG, Velazquez MNR, Jørgensen FS, Pandey AV, Laursen T, Møller BL, Hatzakis NS., Free PMC Article | 05/8/2021 |
| Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1. | Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1.
Yan B, Ai Y, Sun Q, Ma Y, Cao Y, Wang J, Zhang Z, Wang X. | 02/6/2021 |
| Association of POR and PPARalpha polymorphisms with risk of anti-tuberculosis drug-induced liver injury in Western Chinese Han population. | Association of POR and PPARα polymorphisms with risk of anti-tuberculosis drug-induced liver injury in Western Chinese Han population.
Zhang C, Jiao L, Bai H, Zhao Z, Hu X, Wang M, Wu T, Peng W, Liu T, Song J, Zhou J, Li M, Lyv M, Zhang J, Chen H, Chen J, Ying B. | 02/6/2021 |
| [Clinical and genetic analysis of a pedigree affected with cytochrome P450 oxidoreductase deficiency]. | [Clinical and genetic analysis of a pedigree affected with cytochrome P450 oxidoreductase deficiency].
Li H, Dong R, Zhang K, Lyu Y, Gao M, Gai Z, Liu Y. | 11/21/2020 |
| The allelic variants of P450 when present with a variant form of POR may show different activities, and combined effects of variations in the P450 enzymes as well as in the POR should be considered when genetic data are available. | Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H.
Parween S, DiNardo G, Baj F, Zhang C, Gilardi G, Pandey AV. | 07/4/2020 |
| Clinical characteristics and CYP3A5/CYP3A4/POR genotypes were collected. | Tacrolimus population pharmacokinetic models according to CYP3A5/CYP3A4/POR genotypes in Chinese Han renal transplant patients.
Zhu W, Xue L, Peng H, Duan Z, Zheng X, Cao D, Wen J, Wei X. | 09/14/2019 |
| A significant correlation between high CYPOR gene expression and shorter recurrence-free survival (RFS), but not overall survival, was found in the cohort of 249 TNBC patients (p = 0.018, HR = 1.77, 95% CI 1.1-2.85), and this correlation was recapitulated in a cohort of 580 basal-like breast cancer patients (p = 0.018, HR = 1.4, 95% CI 1.06-1.86). | CYPOR is a novel and independent prognostic biomarker of recurrence-free survival in triple-negative breast cancer patients.
Pedersen MH, Hood BL, Ehmsen S, Beck HC, Conrads TP, Bak M, Ditzel HJ, Leth-Larsen R. | 04/27/2019 |
| Domain motion is intrinsically linked to the functionality of the enzyme, and the authors can define the position of the conformational equilibrium for individual steps in the catalytic cycle. | Orchestrated Domain Movement in Catalysis by Cytochrome P450 Reductase.
Freeman SL, Martel A, Raven EL, Roberts GCK., Free PMC Article | 04/20/2019 |
| Data suggest that the highly flexible hinge of CPR is responsible for the existence of a conformational aggregate of different open CPR conformers enabling electron transfer-interaction with structural varied redox partners. | Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450.
Campelo D, Esteves F, Brito Palma B, Costa Gomes B, Rueff J, Lautier T, Urban P, Truan G, Kranendonk M., Free PMC Article | 03/30/2019 |
| The positive influence of mutations in the POR gene on TAC exposure at 3 months after kidney transplantation. | Impact of single nucleotide polymorphisms on P450 oxidoreductase and peroxisome proliferator-activated receptor alpha on tacrolimus pharmacokinetics in renal transplant recipients.
Si S, Wang Z, Yang H, Han Z, Tao J, Chen H, Wang K, Guo M, Tan R, Wei JF, Gu M. | 03/23/2019 |
| POR-BRAF gene fusion is associated with radiation-associated Thyroid Cancer. | Investigation of the Relationship Between Radiation Dose and Gene Mutations and Fusions in Post-Chernobyl Thyroid Cancer.
Efanov AA, Brenner AV, Bogdanova TI, Kelly LM, Liu P, Little MP, Wald AI, Hatch M, Zurnadzy LY, Nikiforova MN, Drozdovitch V, Leeman-Neill R, Mabuchi K, Tronko MD, Chanock SJ, Nikiforov YE., Free PMC Article | 03/2/2019 |
| Coffee consumption is causally associated with an increased risk of osteoarthritis. SNPs in NCALD, POR, CYP1A1 and NRCAM were identified. | Investigating the possible causal association of coffee consumption with osteoarthritis risk using a Mendelian randomization analysis.
Lee YH. | 02/23/2019 |