Expression of the phagocytic receptors alphaMbeta2 and alphaXbeta2 is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells. | Expression of the phagocytic receptors α(M)β(2) and α(X)β(2) is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells. Torres-Gomez A, Fiyouzi T, Guerra-Espinosa C, Cardeñes B, Clares I, Toribio V, Reche PA, Cabañas C, Lafuente EM., Free PMC Article | 10/22/2022 |
Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM). | Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM). Sari-Ak D, Torres-Gomez A, Yazicioglu YF, Christofides A, Patsoukis N, Lafuente EM, Boussiotis VA., Free PMC Article | 07/2/2022 |
Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM. | Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM. Cho EA, Zhang P, Kumar V, Kavalchuk M, Zhang H, Huang Q, Duncan JS, Wu J., Free PMC Article | 11/27/2021 |
RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment. | RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment. Torres-Gomez A, Sanchez-Trincado JL, Toribio V, Torres-Ruiz R, Rodríguez-Perales S, Yáñez-Mó M, Reche PA, Cabañas C, Lafuente EM., Free PMC Article | 02/27/2021 |
Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force. | Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force. Vigouroux C, Henriot V, Le Clainche C., Free PMC Article | 08/29/2020 |
We solved the crystal structure of IN-RA-PH to a resolution of 2.4-A. The structure reveals that the IN segment associates with the RA segment and thereby suppresses RIAM:RAP1 association. This autoinhibitory configuration of RIAM can be released by phosphorylation at Tyr45 in the IN segment. | Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation. Chang YC, Su W, Cho EA, Zhang H, Huang Q, Philips MR, Wu J., Free PMC Article | 05/4/2019 |
Authors provide an overview of the structure and interactions of RIAM and discuss the implications of RIAM functions in innate and adaptive immunity and cancer. [Review] | The adaptor molecule RIAM integrates signaling events critical for integrin-mediated control of immune function and cancer progression. Patsoukis N, Bardhan K, Weaver JD, Sari D, Torres-Gomez A, Li L, Strauss L, Lafuente EM, Boussiotis VA. | 01/13/2018 |
The Rap1-RIAM-talin axis of integrin activation and blood cell function | The Rap1-RIAM-talin axis of integrin activation and blood cell function. Lagarrigue F, Kim C, Ginsberg MH., Free PMC Article | 08/5/2017 |
Disruption of the RIAM/lamellipodin-integrin-talin complex markedly impairs cell migration. | A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration. Lagarrigue F, Vikas Anekal P, Lee HS, Bachir AI, Ablack JN, Horwitz AF, Ginsberg MH., Free PMC Article | 06/28/2016 |
RIAM is a critical component of the phagocytosis machinery downstream of Rap1 and mediates its function by recruiting talin to the phagocytic complement receptors. | RIAM (Rap1-interacting adaptor molecule) regulates complement-dependent phagocytosis. Medraño-Fernandez I, Reyes R, Olazabal I, Rodriguez E, Sanchez-Madrid F, Boussiotis VA, Reche PA, Cabañas C, Lafuente EM., Free PMC Article | 08/31/2013 |
integrin-triggered, RIAM-dependent MEK activation represents a key feedback event required for efficient focal adhesion disassembly. | Focal adhesion disassembly is regulated by a RIAM to MEK-1 pathway. Coló GP, Hernández-Varas P, Lock J, Bartolomé RA, Arellano-Sánchez N, Strömblad S, Teixidó J. | 07/20/2013 |
RIAM was recruited to the lymphocyte plasma membrane through its Ras association and pleckstrin homology domains, both of which were required for lymphocyte adhesion. | Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector. Wynne JP, Wu J, Su W, Mor A, Patsoukis N, Boussiotis VA, Hubbard SR, Philips MR., Free PMC Article | 01/12/2013 |
RIAM might contribute to the dissemination of melanoma cells. | Rap1-GTP-interacting adaptor molecule (RIAM) protein controls invasion and growth of melanoma cells. Hernández-Varas P, Coló GP, Bartolomé RA, Paterson A, Medraño-Fernández I, Arellano-Sánchez N, Cabañas C, Sánchez-Mateos P, Lafuente EM, Boussiotis VA, Strömblad S, Teixidó J., Free PMC Article | 07/30/2011 |
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
by regulating the localization of PLC-gamma1, RIAM plays a central role in TCR signaling and the transcription of target genes. | RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells. Patsoukis N, Lafuente EM, Meraner P, Kim Js, Dombkowski D, Li L, Boussiotis VA., Free PMC Article | 04/12/2010 |
a minimized 50-residue Rap-RIAM module containing the talin binding site of RIAM joined to the membrane-targeting sequence of Rap1A. This minimized Rap-RIAM module was sufficient to target talin to the plasma membrane and to mediate integrin activation | RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. Lee HS, Lim CJ, Puzon-McLaughlin W, Shattil SJ, Ginsberg MH., Free PMC Article | 01/21/2010 |
Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesAssociation studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. Morgan AR, Turic D, Jehu L, Hamilton G, Hollingworth P, Moskvina V, Jones L, Lovestone S, Brayne C, Rubinsztein DC, Lawlor B, Gill M, O'Donovan MC, Owen MJ, Williams J. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. | 03/13/2008 |
Data pinpoint PREL1 as the first direct link between Ras signalling and cytoskeletal remodelling via Ena/VASP proteins during cell migration and spreading. | PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins. Jenzora A, Behrendt B, Small JV, Wehland J, Stradal TE. | 01/21/2010 |
all-trans-retinoic acid-inducible RARP1 selectively affects signal transduction and may contribute to myeloid and megakaryocytic differentiation.(RARP1) | The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells. Inagaki T, Suzuki S, Miyamoto T, Takeda T, Yamashita K, Komatsu A, Yamauchi K, Hashizume K. | 01/21/2010 |