| Activation of Bivalent Gene POU4F1 Promotes and Maintains Basal-like Breast Cancer. | Activation of Bivalent Gene POU4F1 Promotes and Maintains Basal-like Breast Cancer.
Zhang J, Miao N, Lao L, Deng W, Wang J, Zhu X, Huang Y, Lin H, Zeng W, Zhang W, Tan L, Yuan X, Zeng X, Zhu J, Chen X, Song E, Yang L, Nie Y, Huang D., Free PMC Article | 07/5/2024 |
| HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma. | HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma.
Heppt MV, Wessely A, Hornig E, Kammerbauer C, Graf SA, Besch R, French LE, Matthies A, Kuphal S, Kappelmann-Fenzl M, Bosserhoff AK, Berking C., Free PMC Article | 02/12/2022 |
| Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor. | Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor.
Webb BD, Evans A, Naidich TP, M Bird L, Parikh S, Fernandez Garcia M, Henderson LB, Millan F, Si Y, Brennand KJ, Hung P, Rucker JC, Wheeler PG, Schadt EE., Free PMC Article | 01/29/2022 |
| No association between POU4F1, POU4F2, ISL1 polymorphisms and normal-tension glaucoma. | No association between POU4F1, POU4F2, ISL1 polymorphisms and normal-tension glaucoma.
Lee JS, Jeoung JW, Oh S, Kim DM, Ahn JH, Kim MJ, Seong MW, Park SS, Kim JY. | 06/26/2021 |
| POU4F1 promotes the resistance of melanoma to BRAF inhibitors through MEK/ERK pathway activation and MITF up-regulation. | POU4F1 promotes the resistance of melanoma to BRAF inhibitors through MEK/ERK pathway activation and MITF up-regulation.
Liu L, Yue Q, Ma J, Liu Y, Zhao T, Guo W, Zhu G, Guo S, Wang S, Gao T, Li C, Shi Q., Free PMC Article | 04/17/2021 |
| POU4F1 confers trastuzumab resistance in HER2-positive breast cancer through regulating ERK1/2 signaling pathway. | POU4F1 confers trastuzumab resistance in HER2-positive breast cancer through regulating ERK1/2 signaling pathway.
Wu D, Jia HY, Wei N, Li SJ. | 03/20/2021 |
| Brn3a/Pou4f1 Functions as a Tumor Suppressor by Targeting c-MET/STAT3 Signaling in Thyroid Cancer. | Brn3a/Pou4f1 Functions as a Tumor Suppressor by Targeting c-MET/STAT3 Signaling in Thyroid Cancer.
Jung SN, Kang YE, Lee GH, Liu L, Oh C, Jin YL, Lim MA, Lee K, Oh T, Won HR, Chang JW, Koo BS. | 02/27/2021 |
| Papillary thyroid carcinoma was characterized by high expression of ESR2 and AR, which was associated with expression and content of nuclear factors Brn-3A and TRIM16. | Reception of Sex Steroid Hormones in Thyroid Papillary Cancer Tissue and Relationship with Expression and Content of Transcription Factors Brn-3α and TRIM16.
Spirina LV, Chizhevskaya SY, Kondakova IV, Choinzonov EL. | 03/23/2019 |
| We report a case of a nine-year-old male who presented with facial nerve stimulation four years after cochlear implantation. A dilated internal auditory meatus was revealed. Genetic analysis demonstrated X-linked deafness type 2 (DFNX2) caused by a novel c.769C T nucleotide change in the POU domain, class 3, transcription factor 4 gene | Facial nerve stimulation following cochlear implantation for X-linked stapes gusher syndrome leading to identification of a novel POU3F4 mutation.
Wester JL, Merna C, Peng KA, Lewis R, Sepahdari AR, Ishiyama G, Hosokawa K, Kumakawa K, Ishiyama A. | 03/25/2017 |
| Brn3a cooperates with activated RAS/RAF signalling by reducing oncogene-induced senescence in melanocytic tumourigenesis. | The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival.
Hohenauer T, Berking C, Schmidt A, Haferkamp S, Senft D, Kammerbauer C, Fraschka S, Graf SA, Irmler M, Beckers J, Flaig M, Aigner A, Höbel S, Hoffmann F, Hermeking H, Rothenfusser S, Endres S, Ruzicka T, Besch R., Free PMC Article | 11/16/2013 |
| Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis. | Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis.
Faryna M, Konermann C, Aulmann S, Bermejo JL, Brugger M, Diederichs S, Rom J, Weichenhan D, Claus R, Rehli M, Schirmacher P, Sinn HP, Plass C, Gerhauser C. | 04/13/2013 |
| PoU4F1 is highly expressed in t(8;21) samples, with AML/ETO appearning to promote some BRN3A expression | AML1/ETO and POU4F1 synergy drives B-lymphoid gene expression typical of t(8;21) acute myeloid leukemia.
Dunne J, Mannari D, Farzaneh T, Gessner A, van Delft FW, Heidenreich O, Young BD, Gascoyne DM. | 07/7/2012 |
| BRN3A possesses anti-apoptotic property, and considering the above results, it may be regarded as the key component in promoting tumorigenic growth in the uterine cervical cells. | Molecular analysis of oncogenicity of the transcription factor, BRN3A, in cervical cancer cells.
Das Purkayastha BP, Roy JK. | 12/17/2011 |
| Ewing sarcoma induce expression of neuronal markers such as BRN3A showing that the function of those same markers may be restricted or controlled in an sarcoma-dependent manner. | EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A.
Gascoyne DM, Dunne J, Behjati S, Sebire NJ, Anderson J, Latchman DS. | 07/12/2010 |
| Dysregulation of POU4F1 is associated with t(8;21) acute myeloid leukemia. | POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature.
Fortier JM, Payton JE, Cahan P, Ley TJ, Walter MJ, Graubert TA., Free PMC Article | 06/14/2010 |
| Hsp27 expression and cell survival are regulated by the POU transcription factor Brn3a | Regulation of Hsp27 expression and cell survival by the POU transcription factor Brn3a.
Farooqui-Kabir SR, Budhram-Mahadeo V, Lewis H, Latchman DS, Marber MS, Heads RJ. | 01/21/2010 |
| Upregulation of Brn-3a is associated with prostate cancer | Brn-3a neuronal transcription factor functional expression in human prostate cancer.
Diss JK, Faulkes DJ, Walker MM, Patel A, Foster CS, Budhram-Mahadeo V, Djamgoz MB, Latchman DS. | 01/21/2010 |
| Brn-3a has a role in differential regulation of different human papilloma virus variants | Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a.
Ndisang D, Faulkes DJ, Gascoyne D, Lee SA, Ripley BJ, Sindos M, Singer A, Budhram-Mahadeo V, Cason J, Latchman DS. | 01/21/2010 |
| genomic organization of the Brn-3a locus and the mechanisms that control the expression of two different proteins from one genomic locus | Gene expression of the POU factor Brn-3a is regulated by two different promoters.
Frass B, Vassen L, Möröy T. | 01/21/2010 |
| oncogenic rearrangement of EWS to produce EWS/Fli-1 may enhance the antiapoptotic effect of Brn-3a and inhibit its ability to promote neuronal differentiation. | The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1.
Gascoyne DM, Thomas GR, Latchman DS. | 01/21/2010 |
| These results indicate that Brn-3a could play an important role in the near future in improving cervical cancer screening. | Detection of cervical neoplasia using measurement of Brn-3a in cervical smears with persistent minor abnormality.
Sindos M, Ndisang D, Pisal N, Chow C, Deery A, Singer A, Latchman D. | 01/21/2010 |
| Measurement of Brn-3a levels in smears can be used to detect a significant proportion of cervical lesions that were missed by Pap smear. | Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia.
Sindos M, Ndisang D, Pisal N, Chow C, Singer A, Latchman DS. | 01/21/2010 |