Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality.
Wang R, Gomez Salazar M, Pruñonosa Cervera I, Coutts A, French K, Pinto MM, Gohlke S, García-Martín R, Blüher M, Schofield CJ, Kourtzelis I, Stimson RH, Bénézech C, Christian M, Schulz TJ, Gudmundsson EF, Jennings LL, Gudnason VG, Chavakis T, Morton NM, Emilsson V, Michailidou Z., Free PMC Article

Low nuclear expression of HIF-hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence-free survival in clear cell renal cell carcinoma.
Luomala L, Mattila K, Vainio P, Nisén H, Pellinen T, Lohi J, Laajala TD, Järvinen P, Koskenniemi AR, Jaakkola P, Mirtti T., Free PMC Article

A Case-Control Study of the Associations between EGLN1 Gene Polymorphisms and COPD.
Li X, Zhang P, Yu J, Zhang C, Shi Y, Wei X, Li H, Zhang X, Lin A, Yang Z, Wang Y, Wang X.

Association of the C allele of rs479200 in the EGLN1 gene with COVID-19 severity in Indian population: a novel finding.
Harit R, De S, Singh PK, Kashyap D, Kumar M, Sahu D, Yadav CP, Mohan M, Singh V, Tomar RS, Pandey KC, Vashisht K., Free PMC Article

Prolyl hydroxylase 2 inhibits glycolytic activity in colorectal cancer via the NF‑κB signaling pathway.
Xiang L, Wei H, Ye W, Wu S, Xie G., Free PMC Article

Loss of prolyl hydroxylase 1 and 2 in SM22α-expressing cells prevents Hypoxia-Induced pulmonary hypertension.
Barnes EA, Ito R, Che X, Alvira CM, Cornfield DN.,

Characterization of genetic variants in the EGLN1/PHD2 gene identified in a European collection of patients with erythrocytosis.
Delamare M, Le Roy A, Pacault M, Schmitt L, Garrec C, Maaziz N, Myllykoski M, Rimbert A, Karaghiannis V, Aral B, Catherwood M, Airaud F, Mansour-Hendili L, Hoogewijs D, Peroni E, Idriss S, Lesieur V, Caillaud A, Si-Tayeb K, Chariau C, Gaignerie A, Rab M, Haferlach T, Meggendorfer M, Bézieau S, Benetti A, Casadevall N, Hirsch P, Rose C, Wemeau M, Galacteros F, Cassinat B, Bellosillo B, Bento C, Van Wijk R, Petrides PE, Randi ML, McMullin MF, Koivunen P, Girodon F, Gardie B, ECYT-3 consortium., Free PMC Article

A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress.
Jiang W, Zhang M, Gao C, Yan C, Gao R, He Z, Wei X, Xiong J, Ruan Z, Yang Q, Li J, Li Q, Zhong Z, Zhang M, Yuan Q, Hu H, Wang S, Hu MM, Cai C, Wu GS, Jiang C, Zhang YL, Zhang CS, Zhang J., Free PMC Article

The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-α.
Song D, Peng K, Palmer BE, Lee FS., Free PMC Article

Differential methylation in EGLN1 associates with blood oxygen saturation and plasma protein levels in high-altitude pulmonary edema.
Sharma K, Mishra A, Singh H, Thinlas T, Pasha MAQ., Free PMC Article

Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2.
Feng T, Zhao X, Gu P, Yang W, Wang C, Guo Q, Long Q, Liu Q, Cheng Y, Li J, Cheung CKY, Wu D, Kong X, Xu Y, Ye D, Hua S, Loomes K, Xu A, Hui X., Free PMC Article

AMP-activated protein kinase α1 phosphorylates PHD2 to maintain systemic iron homeostasis.
Wang C, Zhang W, Xu W, Liu Z, Huang K., Free PMC Article

High-altitude pulmonary edema is aggravated by risk loci and associated transcription factors in HIF-prolyl hydroxylases.
Sharma K, Mishra A, Singh HN, Parashar D, Alam P, Thinlas T, Mohammad G, Kukreti R, Syed MA, Pasha MAQ.

Gain-of-function Tibetan PHD2(D4E;C127S) variant suppresses monocyte function: A lesson in inflammatory response to inspired hypoxia.
Bhattacharya S, Shrimali NM, Mohammad G, Koul PA, Prchal JT, Guchhait P., Free PMC Article

An integrative functional genomics approach reveals EGLN1 as a novel therapeutic target in KRAS mutated lung adenocarcinoma.
Reggiani F, Sauta E, Torricelli F, Zanetti E, Tagliavini E, Santandrea G, Gobbi G, Damia G, Bellazzi R, Ambrosetti D, Ciarrocchi A, Sancisi V., Free PMC Article

Inhibiting PHD2 in human periodontal ligament cells via lentiviral vector-mediated RNA interference facilitates cell osteogenic differentiation and periodontal repair.
Cui D, Chen C, Luo B, Yan F.

Isolated Erythrocytosis Associated With 3 Novel Missense Mutations in the EGLN1 Gene.
Moore JA, Hubbi ME, Wang C, Wang Y, Luo W, Hofmann S, Rambally S., Free PMC Article

Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
Chowdhury R, Abboud MI, McAllister TE, Banerji B, Bhushan B, Sorensen JL, Kawamura A, Schofield CJ., Free PMC Article

Effect of EGLN1 Genetic Polymorphisms on Hemoglobin Concentration in Andean Highlanders.
Yasukochi Y, Nishimura T, Ugarte J, Ohnishi M, Nishihara M, Alvarez G, Fukuda H, Mendoza V, Aoyagi K., Free PMC Article

Label-Free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2.
Luo A, Chen Y., Free PMC Article

Hypoxia responsiveness linked variant in EGLN1 gene is enriched in oral cancer patients.
Francis I, Arcot M, Mohiyuddin S M A, Balakrishna S.

ERK Regulates HIF1α-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer.
Li Z, Zhou W, Zhang Y, Sun W, Yung MMH, Sun J, Li J, Chen CW, Li Z, Meng Y, Chai J, Zhou Y, Liu SS, Cheung ANY, Ngan HYS, Chan DW, Zheng W, Zhu W., Free PMC Article

Tibetan PHD2, an allele with loss-of-function properties.
Song D, Navalsky BE, Guan W, Ingersoll C, Wang T, Loro E, Eeles L, Matchett KB, Percy MJ, Walsby-Tickle J, McCullagh JSO, Medina RJ, Khurana TS, Bigham AW, Lappin TR, Lee FS., Free PMC Article

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.
Erber L, Luo A, Chen Y., Free PMC Article

The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2.
Kozlova N, Mennerich D, Samoylenko A, Dimova EY, Koivunen P, Biterova E, Richter K, Hassinen A, Kellokumpu S, Manninen A, Miinalainen I, Glumoff V, Ruddock L, Drobot LB, Kietzmann T.