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    Atp8b1 ATPase, class I, type 8B, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 54670, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development.

    Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development.
    Yang WJ, Cao RC, Xiao W, Zhang XL, Xu H, Wang M, Zhou ZT, Chen HJ, Xu J, Chen XM, Zeng JL, Li SJ, Luo M, Han YJ, Yang XB, Feng GD, Lu YH, Ni YY, Wu CG, Bai JJ, Yuan ZQ, Jin J, Zhang GW., Free PMC Article

    11/5/2022
    Matrix Metalloproteinase 7 Expression and Apical Epithelial Defects in Atp8b1 Mutant Mouse Model of Pulmonary Fibrosis.

    Matrix Metalloproteinase 7 Expression and Apical Epithelial Defects in Atp8b1 Mutant Mouse Model of Pulmonary Fibrosis.
    Westermann-Clark E, Soundararajan R, Fukumoto J, Patil SS, Stearns TM, Saji S, Czachor A, Hernandez-Cuervo H, Breitzig M, Krishnamurthy S, Lockey RF, Kolliputi N., Free PMC Article

    04/16/2022
    ATP8B1 is important for proper CFTR expression and function.

    The phospholipid flippase ATP8B1 mediates apical localization of the cystic fibrosis transmembrane regulator.
    van der Mark VA, de Jonge HR, Chang JC, Ho-Mok KS, Duijst S, Vidović D, Carlon MS, Oude Elferink RP, Paulusma CC.

    06/3/2017
    to become apically clustered, Cdc42 requires the interaction between its polybasic region and negatively charged membrane lipids provided by ATP8B1.

    ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.
    Bruurs LJ, Donker L, Zwakenberg S, Zwartkruis FJ, Begthel H, Knisely AS, Posthuma G, van de Graaf SF, Paulusma CC, Bos JL., Free PMC Article

    12/26/2015
    The authors show that two of these transporters, ABCB11 and ATP8B1, are functional targets of miR-33, a micro-RNA that is expressed from within an intron of SREBP-2.

    miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity.
    Allen RM, Marquart TJ, Albert CJ, Suchy FJ, Wang DQ, Ananthanarayanan M, Ford DA, Baldán A., Free PMC Article

    01/26/2013
    Flippase ATP8B1 and the floppase ABCB4 have complementary functions in maintaining canalicular membrane integrity.

    Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.
    Groen A, Romero MR, Kunne C, Hoosdally SJ, Dixon PH, Wooding C, Williamson C, Seppen J, Van den Oever K, Mok KS, Paulusma CC, Linton KJ, Oude Elferink RP.

    01/21/2012
    results unveil a new paradigm whereby Atp8b1 is a cardiolipin importer whose capacity to remove cardiolipin from lung fluid is exceeded during inflammation or when Atp8b1 is defective

    Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia.
    Ray NB, Durairaj L, Chen BB, McVerry BJ, Ryan AJ, Donahoe M, Waltenbaugh AK, O'Donnell CP, Henderson FC, Etscheidt CA, McCoy DM, Agassandian M, Hayes-Rowan EC, Coon TA, Butler PL, Gakhar L, Mathur SN, Sieren JC, Tyurina YY, Kagan VE, McLennan G, Mallampalli RK., Free PMC Article

    11/6/2010
    Data show that ATP8B1-deficient pups of B6 background gained less weight.

    Strain background modifies phenotypes in the ATP8B1-deficient mouse.
    Shah S, Sanford UR, Vargas JC, Xu H, Groen A, Paulusma CC, Grenert JP, Pawlikowska L, Sen S, Elferink RP, Bull LN., Free PMC Article

    10/4/2010
    show that ATP8B1/Atp8b1 deficiency, both in patients and in Atp8b1(G308V/G308V) mutant mice, causes hearing loss, associated with progressive degeneration of cochlear hair cells

    ATP8B1 is essential for maintaining normal hearing.
    Stapelbroek JM, Peters TA, van Beurden DH, Curfs JH, Joosten A, Beynon AJ, van Leeuwen BM, van der Velden LM, Bull L, Oude Elferink RP, van Zanten BA, Klomp LW, Houwen RH., Free PMC Article

    01/21/2010
    Increased biliary cholesterol excretion in Atp8b1-deficient mice is independent of Abcg5/8 activity.

    Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice.
    Groen A, Kunne C, Jongsma G, van den Oever K, Mok KS, Petruzzelli M, Vrins CL, Bull L, Paulusma CC, Oude Elferink RP.

    01/21/2010
    The accumulation of bile salt (BS) in plasma of Atp8b1(G308V/G308V) mice during BS feeding is not caused by increased intestinal BS absorption.

    Intestinal bile salt absorption in Atp8b1 deficient mice.
    Groen A, Kunne C, Paulusma CC, Kramer W, Agellon LB, Bull LN, Oude Elferink RP.

    01/21/2010
    Atp8b1 deficiency causes loss of canalicular phospholipid membrane asymmetry that in turn renders the canalicular membrane less resistant toward hydrophobic bile salts.

    Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport.
    Paulusma CC, Groen A, Kunne C, Ho-Mok KS, Spijkerboer AL, Rudi de Waart D, Hoek FJ, Vreeling H, Hoeben KA, van Marle J, Pawlikowska L, Bull LN, Hofmann AF, Knisely AS, Oude Elferink RP.

    01/21/2010
    Fic1 is expressed in a tissue-specific and developmentally regulated fashion at the apical membranes of epithelial cells

    Fic1 is expressed at apical membranes of different epithelial cells in the digestive tract and is induced in the small intestine during postnatal development of mice.
    van Mil SW, van Oort MM, van den Berg IE, Berger R, Houwen RH, Klomp LW.

    01/21/2010
    mutation disrupts bile salt homeostasis without impairment of canalicular bile secretion

    A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion.
    Pawlikowska L, Groen A, Eppens EF, Kunne C, Ottenhoff R, Looije N, Knisely AS, Killeen NP, Bull LN, Elferink RP, Freimer NB.

    01/21/2010
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