| Mediator complex subunit 1 promotes oral squamous cell carcinoma progression by activating MMP9 transcription and suppressing CD8[+] T cell antitumor immunity. | Mediator complex subunit 1 promotes oral squamous cell carcinoma progression by activating MMP9 transcription and suppressing CD8(+) T cell antitumor immunity.
Li Z, Sun M, Yang R, Wang Z, Zhu Q, Zhang Y, Yang H, Meng Z, Hu L, Sui L., Free PMC Article | 10/1/2024 |
| Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation. | Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation.
Chaudhuri SM, Weinberg SE, Wang D, Yalom LK, Montauti E, Iyer R, Tang AY, Torres Acosta MA, Shen J, Mani NL, Wang S, Liu K, Lu W, Bui TM, Manzanares LD, Dehghani Z, Wai CM, Gao B, Wei J, Yue F, Cui W, Singer BD, Sumagin R, Zhang Y, Fang D., Free PMC Article | 03/25/2024 |
| MED1 induces M2 polarization of tumor-associated macrophages to aggravate breast cancer. | MED1 induces M2 polarization of tumor-associated macrophages to aggravate breast cancer.
Shen Y, Zhou L, Xu M, Tan Z, Yao K, Wang W. | 12/1/2023 |
| Mediator subunit MED1 deficiency prevents carbon tetrachloride-induced hepatic fibrosis in mice. | Mediator subunit MED1 deficiency prevents carbon tetrachloride-induced hepatic fibrosis in mice.
Gao J, Bao M, Xing Y, Ding Y, Han T, Wen E, Liu J, Yue S, Wang R, Wang L, Liu J, Zhao S, Huang J, Liu E, Bai L. | 10/2/2023 |
| Mediator subunit MED1 differentially modulates mutant thyroid hormone receptor intracellular dynamics in Resistance to Thyroid Hormone syndrome. | Mediator subunit MED1 differentially modulates mutant thyroid hormone receptor intracellular dynamics in Resistance to Thyroid Hormone syndrome.
Wang M, Roggero VR, Allison LA., Free PMC Article | 11/26/2022 |
| Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis. | Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis.
Chen X, Kong D, Deng J, Mo F, Liang J. | 10/15/2022 |
| Targeting cyclin-dependent kinase 7-association between CDK7 and pMED1 expression in prostate cancer tissue. | Targeting cyclin-dependent kinase 7-association between CDK7 and pMED1 expression in prostate cancer tissue.
Paulsen FO, Kang D, Becker F, Roth D, Joerg V, Dreyer E, Roesch MC, Seidel C, Merseburger AS, Kirfel J, Sailer V, Offermann A, Perner S. | 10/15/2022 |
| MED1 Downregulation Contributes to TGFbeta-Induced Metastasis by Inhibiting SMAD2 Ubiquitination Degradation in Cutaneous Melanoma. | MED1 Downregulation Contributes to TGFβ-Induced Metastasis by Inhibiting SMAD2 Ubiquitination Degradation in Cutaneous Melanoma.
Li Y, Wu J, Tian Y, Zhu Q, Ge Y, Yu H, Huang J, Li H, Zhang J, Zhang L, Hu L. | 07/30/2022 |
| Phosphorylated MED1 links transcription recycling and cancer growth. | Phosphorylated MED1 links transcription recycling and cancer growth.
Chen Z, Ye Z, Soccio RE, Nakadai T, Hankey W, Zhao Y, Huang F, Yuan F, Wang H, Cui Z, Sunkel B, Wu D, Dzeng RK, Thomas-Ahner JM, Huang THM, Clinton SK, Huang J, Lazar MA, Jin VX, Roeder RG, Wang Q., Free PMC Article | 05/14/2022 |
| Preparation of MED1(transcription mediator subunit) gene nanocarrier and its mechanism of action on liver cell regeneration in chronic acute liver failure. | Preparation of MED1(transcription mediator subunit) gene nanocarrier and its mechanism of action on liver cell regeneration in chronic acute liver failure.
Guo J, Zhang Z, Zhu J., Free PMC Article | 02/26/2022 |
| Mediator subunit MED1 modulates intranuclear dynamics of the thyroid hormone receptor. | Mediator subunit MED1 modulates intranuclear dynamics of the thyroid hormone receptor.
Femia MR, Evans RM, Zhang J, Sun X, Lebegue CJ, Roggero VR, Allison LA., Free PMC Article | 07/10/2021 |
| Mediator subunit MED1 is required for E2A-PBX1-mediated oncogenic transcription and leukemic cell growth. | Mediator subunit MED1 is required for E2A-PBX1-mediated oncogenic transcription and leukemic cell growth.
Lee YL, Ito K, Pi WC, Lin IH, Chu CS, Malik S, Cheng IH, Chen WY, Roeder RG., Free PMC Article | 06/26/2021 |
| Molecular determinants of MED1 interaction with the DNA bound VDR-RXR heterodimer. | Molecular determinants of MED1 interaction with the DNA bound VDR-RXR heterodimer.
Belorusova AY, Bourguet M, Hessmann S, Chalhoub S, Kieffer B, Cianférani S, Rochel N., Free PMC Article | 11/21/2020 |
| Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer. | Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer.
Liu X, Qian D, Liu H, Abbruzzese JL, Luo S, Walsh KM, Wei Q., Free PMC Article | 10/10/2020 |
| Here, we report that, in human cancer cells, BRD4S forms nuclear puncta that possess liquid-like properties and that colocalize with BRD4L, MED1 and sites of histone H3 lysine 27 acetylation. BRD4 puncta are correlated with BRD4S but not BRD4L expression levels. | Roles of the BRD4 short isoform in phase separation and active gene transcription.
Han X, Yu D, Gu R, Jia Y, Wang Q, Jaganathan A, Yang X, Yu M, Babault N, Zhao C, Yi H, Zhang Q, Zhou MM, Zeng L. | 07/18/2020 |
| It has been demonstrated that induction of double-strand DNA breaks results in the assembly of functional promoters that include a complete RNA polymerase II preinitiation complex, MED1 and CDK9. | Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors.
Pessina F, Giavazzi F, Yin Y, Gioia U, Vitelli V, Galbiati A, Barozzi S, Garre M, Oldani A, Flaus A, Cerbino R, Parazzoli D, Rothenberg E, d'Adda di Fagagna F., Free PMC Article | 02/15/2020 |
| MED1 is an estrogen receptor coactivator that is a tissue-specific therapeutic target in breast cancer [review] | Estrogen receptor coactivator Mediator Subunit 1 (MED1) as a tissue-specific therapeutic target in breast cancer.
Leonard M, Zhang X., Free PMC Article | 12/14/2019 |
| results show that MED1/ER-alpha/miR-191 axis promotes breast cancer cell proliferation and migration and may serve as a novel target for therapy. | Essential role of MED1 in the transcriptional regulation of ER-dependent oncogenic miRNAs in breast cancer.
Nagpal N, Sharma S, Maji S, Durante G, Ferracin M, Thakur JK, Kulshreshtha R., Free PMC Article | 10/26/2019 |
| results suggest that PML-RARalpha initiates all-trans retinoic acid -induced transcription through its interaction with MED1 | PML-RARα induces all-trans retinoic acid-dependent transcriptional activation through interaction with MED1.
Fukuoka T, Kawai A, Takahara T, Mori M, Roeder RG, Hasegawa N, Ito M., Free PMC Article | 09/14/2019 |
| High MED1 expression is associated with metastasis in breast Cancer. | HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1.
Yang Y, Leonard M, Zhang Y, Zhao D, Mahmoud C, Khan S, Wang J, Lower EE, Zhang X., Free PMC Article | 11/3/2018 |
| maintenance of the cancer cell state is dependent on recruitment of Mediator and Cohesin through FOXA and master transcription factors | FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells.
Fournier M, Bourriquen G, Lamaze FC, Côté MC, Fournier É, Joly-Beauparlant C, Caron V, Gobeil S, Droit A, Bilodeau S., Free PMC Article | 06/30/2018 |
| co-expression of PPARgamma and TRAP220 represents a biomarker for good prognosis in colorectal cancer patients | Clinical Significance of Peroxisome Proliferator-Activated Receptor γ and TRAP220 in Patients with Operable Colorectal Cancer.
Kwon KA, Yun J, Oh SY, Seo BG, Lee S, Lee JH, Kim SH, Choi HJ, Roh MS, Kim HJ., Free PMC Article | 06/16/2018 |
| Data suggest that mediator complex subunit 1 (Med1/TRAP220) is a target for checkpoint kinase 2 (Chk2)-mediated phosphorylation and may play a role in cellular DNA damage responses by mediating proper induction of gene transcription upon DNA damage. | Checkpoint-dependent phosphorylation of Med1/TRAP220 in response to DNA damage.
Kim HJ, Yun J. | 04/14/2018 |
| In a cohort of youth at risk for bipolar disorder, pathway analysis showed an enrichment of the glucocorticoid receptor (GR) pathway with the genes MED1, HSPA1L, GTF2A1 and TAF15, which might underlie the previously reported role of stress response in the risk for bipolar disorder in vulnerable populations. | Integrated transcriptome and methylome analysis in youth at high risk for bipolar disorder: a preliminary analysis.
Fries GR, Quevedo J, Zeni CP, Kazimi IF, Zunta-Soares G, Spiker DE, Bowden CL, Walss-Bass C, Soares JC., Free PMC Article | 11/25/2017 |
| modulation of ESR1-MED1 interactions by cAMP signaling plays a critical role in human decidualization. | Roles of Estrogen Receptor-α and the Coactivator MED1 During Human Endometrial Decidualization.
Kaya Okur HS, Das A, Taylor RN, Bagchi IC, Bagchi MK., Free PMC Article | 12/17/2016 |