| MARCH5 promotes hepatocellular carcinoma progression by inducing p53 ubiquitination degradation. | MARCH5 promotes hepatocellular carcinoma progression by inducing p53 ubiquitination degradation.
Cai X, Gao J, Yan Z, Zhang H, Guo D, Zhang S., Free PMC Article | 09/10/2024 |
| PD-1 signaling negatively regulates the common cytokine receptor gamma chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity. | PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.
Liu R, Zeng LW, Li HF, Shi JG, Zhong B, Shu HB, Li S., Free PMC Article | 04/8/2024 |
| A decrease of mitochondrial ubiquitin ligase increases the secretion of matrix metalloproteinase-1 by dermal fibroblasts through the induction of ER stress. | A decrease of mitochondrial ubiquitin ligase increases the secretion of matrix metalloproteinase-1 by dermal fibroblasts through the induction of ER stress.
Katsuyama Y, Okano Y, Masaki H. | 02/21/2024 |
| MARCH5-mediated downregulation of ACC2 promotes fatty acid oxidation and tumor progression in ovarian cancer. | MARCH5-mediated downregulation of ACC2 promotes fatty acid oxidation and tumor progression in ovarian cancer.
Zhao S, Wang Q, Zhang X, Ma B, Shi Y, Yin Y, Kong W, Zhang W, Li J, Yang H. | 02/1/2024 |
| Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy. | Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.
Hussain M, Mohammed A, Saifi S, Priya S, Sengupta S., Free PMC Article | 10/4/2023 |
| Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy. | Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy.
Zheng J, Chen X, Liu Q, Zhong G, Zhuang M., Free PMC Article | 12/25/2021 |
| The XBP1MARCH5MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma. | The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.
Wang H, Yi X, Guo S, Wang S, Ma J, Zhao T, Shi Q, Tian Y, Wang H, Jia L, Gao T, Li C, Guo W. | 12/11/2021 |
| MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex. | MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.
Djajawi TM, Liu L, Gong JN, Huang AS, Luo MJ, Xu Z, Okamoto T, Call MJ, Huang DCS, van Delft MF., Free PMC Article | 09/25/2021 |
| MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment. | MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment.
Haschka MD, Karbon G, Soratroi C, O'Neill KL, Luo X, Villunger A., Free PMC Article | 09/25/2021 |
| MARCH5 restores endothelial cell function against ischaemic/hypoxia injury via Akt/eNOS pathway. | MARCH5 restores endothelial cell function against ischaemic/hypoxia injury via Akt/eNOS pathway.
Lei W, Li J, Li C, Chen L, Huang F, Xiao D, Zhang J, Zhao J, Li G, Qu T, Zhou H, Liao Y, Chen M., Free PMC Article | 09/18/2021 |
| MITOL-dependent ubiquitylation negatively regulates the entry of PolgammaA into mitochondria. | MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria.
Hussain M, Mohammed A, Saifi S, Khan A, Kaur E, Priya S, Agarwal H, Sengupta S., Free PMC Article | 07/31/2021 |
| Dual targeting of RIG-I and MAVS by MARCH5 mitochondria ubiquitin ligase in innate immunity. | Dual targeting of RIG-I and MAVS by MARCH5 mitochondria ubiquitin ligase in innate immunity.
Park YJ, Oanh NTK, Heo J, Kim SG, Lee HS, Lee H, Lee JH, Kang HC, Lim W, Yoo YS, Cho H. | 06/12/2021 |
| MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation. | MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation.
Arai S, Varkaris A, Nouri M, Chen S, Xie L, Balk SP., Free PMC Article | 03/27/2021 |
| Mitochondria ubiquitin ligase, MARCH5 resolves hepatitis B virus X protein aggregates in the liver pathogenesis. | Mitochondria ubiquitin ligase, MARCH5 resolves hepatitis B virus X protein aggregates in the liver pathogenesis.
Yoo YS, Park YJ, Lee HS, Oanh NTK, Cho MY, Heo J, Lee ES, Cho H, Park YY, Cho H., Free PMC Article | 09/5/2020 |
| Ubiquitylation of MITOL at K268 by Parkin is required for p97/VCP-dependent redistribution from mitochondria to peroxisomes. | Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes.
Koyano F, Yamano K, Kosako H, Kimura Y, Kimura M, Fujiki Y, Tanaka K, Matsuda N., Free PMC Article | 05/23/2020 |
| Study identified IRE1a as a novel substrate for MITOL. MITOL modifies the lysine (K) 481 of IRE1a by adding a K63-linked polyubiquitin chain, which in turn suppresses the activity and oligomerization of IRE1a. These data provide evidence that MITOL can directly regulate IRE1a through the mitochondria-associated ER membrane (MAM) and thus play an important role in determining cell fate under ER stress. | MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.
Takeda K, Nagashima S, Shiiba I, Uda A, Tokuyama T, Ito N, Fukuda T, Matsushita N, Ishido S, Iwawaki T, Uehara T, Inatome R, Yanagi S., Free PMC Article | 12/28/2019 |
| Data demonstrate a lower abundance of MARCH5 protein in white adipose tissue from the obese group with subsequently impaired fasting blood glucose levels than in lean individuals with normal glucose tolerance, confirming that MARCH5 is reduced in the setting of obesity and metabolic dysregulation. | The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes.
Bond ST, Moody SC, Liu Y, Civelek M, Villanueva CJ, Gregorevic P, Kingwell BA, Hevener AL, Lusis AJ, Henstridge DC, Calkin AC, Drew BG., Free PMC Article | 11/23/2019 |
| the results of this study identified MARCH5 as a candidate oncogene in ovarian cancer and a potential target for ovarian cancer therapy. | MARCH5 RNA promotes autophagy, migration, and invasion of ovarian cancer cells.
Hu J, Meng Y, Zhang Z, Yan Q, Jiang X, Lv Z, Hu L., Free PMC Article | 12/2/2017 |
| MARCH5 directly interacts with FUNDC1 to mediate its ubiquitylation at lysine 119 for subsequent degradation. | Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy.
Chen Z, Liu L, Cheng Q, Li Y, Wu H, Zhang W, Wang Y, Sehgal SA, Siraj S, Wang X, Wang J, Zhu Y, Chen Q., Free PMC Article | 08/19/2017 |
| These findings and data showing MARCH5-dependent degradation of MiD49 upon stress support the possibility that MARCH5 regulation of MiD49 is a novel mechanism controlling mitochondrial fission and, consequently, the cellular response to stress. | Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein.
Xu S, Cherok E, Das S, Li S, Roelofs BA, Ge SX, Polster BM, Boyman L, Lederer WJ, Wang C, Karbowski M., Free PMC Article | 12/17/2016 |
| Self-clearance mechanism of mitochondrial ligase MARCH5 contributes to mitochondria quality control.MARCH5 is regulated by auto-ubiquitination. | Self-clearance mechanism of mitochondrial E3 ligase MARCH5 contributes to mitochondria quality control.
Kim SH, Park YY, Yoo YS, Cho H. | 07/30/2016 |
| MARCH5 binds MAVS only during viral stimulation when MAVS forms aggregates, and these interactions require the RING domain of MARCH5 and the CARD domain of MAVS. | The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling.
Yoo YS, Park YY, Kim JH, Cho H, Kim SH, Lee HS, Kim TH, Sun Kim Y, Lee Y, Kim CJ, Jung JU, Lee JS, Cho H., Free PMC Article | 05/14/2016 |
| Our results indicate that HDAC6 is a critical regulator of MFN2 degradation by MARCH5, thus protecting mitochondrial connectivity from hypoxic stress. | HDAC6 maintains mitochondrial connectivity under hypoxic stress by suppressing MARCH5/MITOL dependent MFN2 degradation.
Kim HJ, Nagano Y, Choi SJ, Park SY, Kim H, Yao TP, Lee JY. | 04/30/2016 |
| A fine balance of Mfn1 levels is maintained by MARCH5-mediated quality control on acetylated Mfn1. | MARCH5-mediated quality control on acetylated Mfn1 facilitates mitochondrial homeostasis and cell survival.
Park YY, Nguyen OT, Kang H, Cho H., Free PMC Article | 05/23/2015 |
| MITOL regulates ER tethering to mitochondria by activating Mfn2 via K192 ubiquitination. | MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2.
Sugiura A, Nagashima S, Tokuyama T, Amo T, Matsuki Y, Ishido S, Kudo Y, McBride HM, Fukuda T, Matsushita N, Inatome R, Yanagi S. | 10/19/2013 |