| Proteomics analysis of serum and urine identifies VCP and CTSA as potential biomarkers associated with multiple myeloma. | Proteomics analysis of serum and urine identifies VCP and CTSA as potential biomarkers associated with multiple myeloma.
Fu W, Song Y, Zhao R, Zhao J, Yue Y, Zhang R. | 12/27/2023 |
| Combining WGCNA and machine learning to construct basement membrane-related gene index helps to predict the prognosis and tumor microenvironment of HCC patients and verifies the carcinogenesis of key gene CTSA. | Combining WGCNA and machine learning to construct basement membrane-related gene index helps to predict the prognosis and tumor microenvironment of HCC patients and verifies the carcinogenesis of key gene CTSA.
Sun W, Wang J, Wang Z, Xu M, Lin Q, Sun P, Yuan Y., Free PMC Article | 06/15/2023 |
| Identification of the prognostic, diagnostic, and biological significance of the miR-148a-3p/cathepsin A axis in hepatocellular carcinoma. | Identification of the prognostic, diagnostic, and biological significance of the miR-148a-3p/cathepsin A axis in hepatocellular carcinoma.
Zhao X, Chai W, Wang T, Chen X, Zhang L, Li F, Liu R. | 12/24/2022 |
| Enhanced carboxypeptidase efficacies and differentiation of peptide epimers. | Enhanced carboxypeptidase efficacies and differentiation of peptide epimers.
Sung YS, Putman J, Du S, Armstrong DW. | 03/12/2022 |
| Cathepsin A knockdown decreases the proliferation and invasion of A549 lung adenocarcinoma cells. | Cathepsin A knockdown decreases the proliferation and invasion of A549 lung adenocarcinoma cells.
Hu B, Zhu X, Lu J., Free PMC Article | 02/13/2021 |
| Paired Carboxylic Acids in Enzymes and Their Role in Selective Substrate Binding, Catalysis, and Unusually Shifted pKa Values | Paired Carboxylic Acids in Enzymes and Their Role in Selective Substrate Binding, Catalysis, and Unusually Shifted pK(a) Values.
Khavrutskii IV, Compton JR, Jurkouich KM, Legler PM. | 06/27/2020 |
| Higher contents of cathepsin A, D, and E in the wall of the aortic aneurysms and a positive correlation between the concentration of cathepsin A and D and the width of the aneurysmal widening, suggests the participation of these enzymes in the pathogenesis of the aneurysm. | The Relationship between the Concentration of Cathepsin A, D, and E and the Concentration of Copper and Zinc, and the Size of the Aneurysmal Enlargement in the Wall of the Abdominal Aortic Aneurysm.
Kurianiuk A, Socha K, Gacko M, Błachnio-Zabielska A, Karwowska A. | 06/1/2019 |
| CTSA expression in the left atrium in mitral regurgitation patients significantly differed from those in aortic valve disease patients and normal controls. | Differential Gene Expression Profile of Renin-Angiotensin System in the Left Atrium in Mitral Regurgitation Patients.
Liu WH, Fang YN, Wu CC, Chen MC, Chang JP, Lin YS, Pan KL, Ho WC, Chang TH, Huang YK, Fang CY, Chen CJ, Lee WC., Free PMC Article | 04/13/2019 |
| The usefulness of modified U1 snRNA for rescue from exon 7 skipping caused by the IVS7 +3a>g mutation of the CTSA gene. | Use of modified U1 small nuclear RNA for rescue from exon 7 skipping caused by 5'-splice site mutation of human cathepsin A gene.
Yamazaki N, Kanazawa K, Kimura M, Ike H, Shinomiya M, Tanaka S, Shinohara Y, Minakawa N, Itoh K, Takiguchi Y. | 10/6/2018 |
| The gene signature of OPA1, CTSA, NDUFA1, STK10 and PRDX1 was able to identify patients post-implant with a sensitivity of 91% and a specificity of 86% in discrimination between post-implant group and healthy controls. | Altered mitochondrial expression genes in patients receiving right ventricular apical pacing.
Xu H, Gao J, Wang F. | 06/24/2017 |
| Galactosialidosis is a rare lysosomal storage disease caused by a combined deficiency of GM1 beta-galactosidase (beta-gal) and neuraminidase secondary to a defect of a lysosomal enzyme protective protein/cathepsin A (PPCA) and mutation in CTSA gene. | Chemical chaperone treatment for galactosialidosis: Effect of NOEV on β-galactosidase activities in fibroblasts.
Hossain MA, Higaki K, Shinpo M, Nanba E, Suzuki Y, Ozono K, Sakai N. | 10/22/2016 |
| Case Report: galactosialidosis with novel mutations of CTSA gene diagnosed using placental pathology. | A case of galactosialidosis with novel mutations of the protective protein/cathepsin a gene: diagnosis prompted by trophoblast vacuolization on placental examination.
Kostadinov S, Shah BA, Alroy J, Phornphutkul C. | 03/21/2015 |
| We identified compound heterozygous mutations in the CTSA gene, responsible for causing galactosialidosis | Clinical utility of whole-exome sequencing in rare diseases: Galactosialidosis.
Prada CE, Gonzaga-Jauregui C, Tannenbaum R, Penney S, Lupski JR, Hopkin RJ, Sutton VR., Free PMC Article | 01/31/2015 |
| correct nomenclature of mutations for this gene is discussed; clinical and mutational analyses of 4 cases with rare infantile form of galactosialidosis; identified 3 novel nucleotide changes, 2 resulting in missense mutations and the third, resulting in the p.Gln406* stop codon; complexity of the clinical phenotypes in GS reflects dual functions of PPCA/CTSA | Galactosialidosis: review and analysis of CTSA gene mutations.
Caciotti A, Catarzi S, Tonin R, Lugli L, Perez CR, Michelakakis H, Mavridou I, Donati MA, Guerrini R, d'Azzo A, Morrone A., Free PMC Article | 01/4/2014 |
| Catalytic function, tissue distribution and substrates of cathepsin A are discussed as well as inhibition of cathepsin A as an emerging strategy for the treatment of heart failure. | Inhibition of CatA: an emerging strategy for the treatment of heart failure.
Ruf S, Buning C, Schreuder H, Linz W, Hübschle T, Linz D, Ruetten H, Wirth K, Sadowski T. | 08/31/2013 |
| The Cathepsin C releases the glycosidases from complexes formed with cathepsin A, and reinstates their activity. | Role of cathepsin A and cathepsin C in the regulation of glycosidase activity.
Minarowska A, Minarowski Ł, Karwowska A, Milewska AJ, Gacko M. | 11/3/2012 |
| Our data suggest that CatA is involved in the C-terminal fine-tuning of antigenic T cell epitopes in human APC. | Cathepsin A is expressed in primary human antigen-presenting cells.
Reich M, Spindler KD, Burret M, Kalbacher H, Boehm BO, Burster T. | 05/10/2010 |
| Results describe the hydrodynamic properties of PPCA, NEU1, and a complex of the two proteins and identified multiple binding sites on both proteins. | Heterodimerization of the sialidase NEU1 with the chaperone protective protein/cathepsin A prevents its premature oligomerization.
Bonten EJ, Campos Y, Zaitsev V, Nourse A, Waddell B, Lewis W, Taylor G, d'Azzo A., Free PMC Article | 01/21/2010 |
| mutations in early infantile galactosialidosis in two Dutch patients | New mutations in two Dutch patients with early infantile galactosialidosis.
Groener J, Maaswinkel-Mooy P, Smit V, van der Hoeven M, Bakker J, Campos Y, d'Azzo A. | 01/21/2010 |
| Increased activity of beta-galactosidase in the peritoneal fluid is associated with gynecologic cancers and pelvic inflammatory disease | Increased activity of lysosomal enzymes in the peritoneal fluid of patients with gynecologic cancers and pelvic inflammatory disease.
Beratis NG, Kaperonis A, Eliopoulou MI, Kourounis G, Tzingounis VA. | 01/21/2010 |
| effects of GLB1, PPCA and NEU1 gene mutations on elastogenesis in skin fibroblasts | Elastogenesis in cultured dermal fibroblasts from patients with lysosomal beta-galactosidase, protective protein/cathepsin A and neuraminidase-1 deficiencies.
Tatano Y, Takeuchi N, Kuwahara J, Sakuraba H, Takahashi T, Takada G, Itoh K. | 01/21/2010 |