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    ESRP1 epithelial splicing regulatory protein 1 [ Homo sapiens (human) ]

    Gene ID: 54845, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Splicing factor ESRP1 derived circ_0068162 promotes the progression of oral squamous cell carcinoma via the miR-186/JAG axis.

    Splicing factor ESRP1 derived circ_0068162 promotes the progression of oral squamous cell carcinoma via the miR-186/JAG axis.
    Chen S, Zong Y, Hou Z, Deng Z, Xia Z.

    03/12/2024
    ESRP1 controls biogenesis and function of a large abundant multiexon circRNA.

    ESRP1 controls biogenesis and function of a large abundant multiexon circRNA.
    Liu D, Dredge BK, Bert AG, Pillman KA, Toubia J, Guo W, Dyakov BJA, Migault MM, Conn VM, Conn SJ, Gregory PA, Gingras AC, Patel D, Wu B, Goodall GJ., Free PMC Article

    02/14/2024
    Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA.

    Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA.
    Wang W, Taufalele PV, Millet M, Homsy K, Smart K, Berestesky ED, Schunk CT, Rowe MM, Bordeleau F, Reinhart-King CA., Free PMC Article

    10/6/2023
    The Role of ESRP1 in the Regulation of PHGDH in Estrogen Receptor-Positive Breast Cancer.

    The Role of ESRP1 in the Regulation of PHGDH in Estrogen Receptor-Positive Breast Cancer.
    Gökmen-Polar Y, Gu Y, Polar A, Gu X, Badve SS.

    03/22/2023
    Overexpression of Epithelial Splicing Regulatory Protein 1 in Metastatic Lesions of Serous Ovarian Carcinoma Correlates with Poor Patient Prognosis.

    Overexpression of Epithelial Splicing Regulatory Protein 1 in Metastatic Lesions of Serous Ovarian Carcinoma Correlates with Poor Patient Prognosis.
    Lu X, Li R, Wang X, Guo Q, Wang L, Zhou X.

    11/26/2022
    Silencing ESRP1 expression promotes caspase-independent cell death via nuclear translocation of AIF in colon cancer cells.

    Silencing ESRP1 expression promotes caspase-independent cell death via nuclear translocation of AIF in colon cancer cells.
    Vadlamudi Y, Kang SC.

    04/9/2022
    MiR-337-3p suppresses migration and invasion of breast cancer cells by downregulating ESRP1.

    MiR-337-3p suppresses migration and invasion of breast cancer cells by downregulating ESRP1.
    Pan Y, Zhao Y, Lihui L, Xie Y, Zou Q.

    02/19/2022
    ESRP1 as a prognostic factor of non-small-cell lung cancer is related to the EMT transcription factor of Twist.

    ESRP1 as a prognostic factor of non-small-cell lung cancer is related to the EMT transcription factor of Twist.
    Cui J, Ren P, Li Y, Ma Y, Wang J, Lin C, Jing L, Tong X, Ma S, Chen J., Free PMC Article

    01/29/2022
    Epithelial Splicing Regulatory Protein 1 Is Overexpressed in Breast Cancer and Predicts Poor Prognosis for Breast Cancer Patients.

    Epithelial Splicing Regulatory Protein 1 Is Overexpressed in Breast Cancer and Predicts Poor Prognosis for Breast Cancer Patients.
    Liu X, Wang Q, Song S, Feng M, Wang X, Li L, Liu Y, Shi C., Free PMC Article

    12/4/2021
    Emerging Multi-cancer Regulatory Role of ESRP1: Orchestration of Alternative Splicing to Control EMT.

    Emerging Multi-cancer Regulatory Role of ESRP1: Orchestration of Alternative Splicing to Control EMT.
    Vadlamudi Y, Dey DK, Kang SC.

    09/18/2021
    ESRP1 regulates alternative splicing of CARM1 to sensitize small cell lung cancer cells to chemotherapy by inhibiting TGF-beta/Smad signaling.

    ESRP1 regulates alternative splicing of CARM1 to sensitize small cell lung cancer cells to chemotherapy by inhibiting TGF-β/Smad signaling.
    Zheng M, Niu Y, Bu J, Liang S, Zhang Z, Liu J, Guo L, Zhang Z, Wang Q., Free PMC Article

    08/21/2021
    APC regulation of ESRP1 and p120-catenin isoforms in colorectal cancer cells.

    APC regulation of ESRP1 and p120-catenin isoforms in colorectal cancer cells.
    Faux MC, King LE, Kane SR, Love C, Sieber OM, Burgess AW., Free PMC Article

    08/14/2021
    Splicing factor derived circular RNA circUHRF1 accelerates oral squamous cell carcinoma tumorigenesis via feedback loop.

    Splicing factor derived circular RNA circUHRF1 accelerates oral squamous cell carcinoma tumorigenesis via feedback loop.
    Zhao W, Cui Y, Liu L, Qi X, Liu J, Ma S, Hu X, Zhang Z, Wang Y, Li H, Wang Z, Liu Z, Wu J., Free PMC Article

    07/3/2021
    Epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) upregulation predicts poor prognosis in prostate cancer.

    Epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) upregulation predicts poor prognosis in prostate cancer.
    Freytag M, Kluth M, Bady E, Hube-Magg C, Makrypidi-Fraune G, Heinzer H, Höflmayer D, Weidemann S, Uhlig R, Huland H, Graefen M, Bernreuther C, Wittmer C, Tsourlakis MC, Minner S, Dum D, Hinsch A, Luebke AM, Simon R, Sauter G, Schlomm T, Möller K., Free PMC Article

    05/1/2021
    Mining Database for the Clinical Significance and Prognostic Value of ESRP1 in Cutaneous Malignant Melanoma.

    Mining Database for the Clinical Significance and Prognostic Value of ESRP1 in Cutaneous Malignant Melanoma.
    Wang B, Li Y, Kou C, Sun J, Xu X., Free PMC Article

    05/1/2021
    Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate cancer.

    Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate cancer.
    Stinnesbeck M, Kristiansen A, Ellinger J, Hauser S, Egevad L, Tolkach Y, Kristiansen G., Free PMC Article

    03/28/2021
    ISG15 induces ESRP1 to inhibit lung adenocarcinoma progression.

    ISG15 induces ESRP1 to inhibit lung adenocarcinoma progression.
    Qu T, Zhang W, Qi L, Cao L, Liu C, Huang Q, Li G, Li L, Wang Y, Guo Q, Guo Y, Ren D, Gao Y, Wang J, Meng B, Zhang B, Cao W., Free PMC Article

    03/27/2021
    Expression of ESRP1 at human fetomaternal interface and involvement in trophoblast migration and invasion.

    Expression of ESRP1 at human fetomaternal interface and involvement in trophoblast migration and invasion.
    Jia J, Shi E, Zhou X, Zhu S, Li J, Zhang J, Yu J, Wang S, Feng L.

    02/6/2021
    Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells.

    Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells.
    Ala U, Manco M, Mandili G, Tolosano E, Novelli F, Provero P, Altruda F, Fagoonee S., Free PMC Article

    11/21/2020
    we have demonstrated that ESRP1 overexpression induces G1-phase cell cycle arrest via reducing the stability of the cyclin A2 mRNA.

    ESRP1 Induces Cervical Cancer Cell G1-Phase Arrest Via Regulating Cyclin A2 mRNA Stability.
    Chen ZH, Jing YJ, Yu JB, Jin ZS, Li Z, He TT, Su XZ., Free PMC Article

    01/11/2020
    effect of ESRP1 and CD44 on human PSC pluripotency is isoform-dependent and that ESRP1-induced CD44 v3 is functionally associated with human PSC pluripotency control

    ESRP1-Induced CD44 v3 Is Important for Controlling Pluripotency in Human Pluripotent Stem Cells.
    Kim YD, Kim HS, Lee J, Choi JK, Han E, Jeong JE, Cho YS.

    11/30/2019
    Low ESRP1 expression is associated with Invasion and Metastasis of Lung Adenocarcinoma.

    Epithelial Splicing Regulatory Protein 1 Inhibits the Invasion and Metastasis of Lung Adenocarcinoma.
    Li L, Qi L, Qu T, Liu C, Cao L, Huang Q, Song W, Yang L, Qi H, Wang Y, Gao B, Guo Y, Sun B, Meng B, Zhang B, Cao W.

    07/13/2019
    study defines a Snail-ESRP1 cancer axis that is crucial for human lung carcinogenesis, with implications for new intervention strategies and translational opportunities

    Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells.
    Walser TC, Jing Z, Tran LM, Lin YQ, Yakobian N, Wang G, Krysan K, Zhu LX, Sharma S, Lee MH, Belperio JA, Ooi AT, Gomperts BN, Shay JW, Larsen JE, Minna JD, Hong LS, Fishbein MC, Dubinett SM., Free PMC Article

    07/6/2019
    Results show that ESRP1 regulates CD44 splice isoform switching and EMT in ovarian cancer cells.

    Mesenchymal splice isoform of CD44 (CD44s) promotes EMT/invasion and imparts stem-like properties to ovarian cancer cells.
    Bhattacharya R, Mitra T, Ray Chaudhuri S, Roy SS.

    11/10/2018
    In humans, ESRP1 is downregulated in inflamed biopsies from inflammatory bowel disease patients. ESRP1 loss is an adverse prognostic factor in colorectal cancer. Furthermore, generation of ESRP1-dependent GPR137 isoforms is altered in colorectal cancer and expression of a specific GPR137 isoform predicts colorectal cancer patient survival.

    The ESRP1-GPR137 axis contributes to intestinal pathogenesis.
    Mager LF, Koelzer VH, Stuber R, Thoo L, Keller I, Koeck I, Langenegger M, Simillion C, Pfister SP, Faderl M, Genitsch V, Tcymbarevich I, Juillerat P, Li X, Xia Y, Karamitopoulou E, Lyck R, Zlobec I, Hapfelmeier S, Bruggmann R, McCoy KD, Macpherson AJ, Müller C, Beutler B, Krebs P., Free PMC Article

    06/23/2018
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