| Hsa-miR-1269a up-regulation fosters the malignant progression of esophageal squamous cell carcinoma via targeting FAM46C. | Hsa-miR-1269a up-regulation fosters the malignant progression of esophageal squamous cell carcinoma via targeting FAM46C.
Ma Y, Xing X, Cheng C, Kong R, Sun L, Zhao F, Zhang D, Li J. | 11/15/2023 |
| FAM46C-mediated tumor heterogeneity predicts extramedullary metastasis and poorer survival in multiple myeloma. | FAM46C-mediated tumor heterogeneity predicts extramedullary metastasis and poorer survival in multiple myeloma.
Zhang W, Wu C, Geng S, Wang J, Yan C, Zhang X, Zhang JJ, Wu F, Pang Y, Zhong Y, Wang J, Fu W, Huang X, Wang W, Lyu X, Huang Y, Jing H., Free PMC Article | 10/30/2023 |
| Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C. | Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C.
Zhang H, Zhang SH, Hu JL, Wu YT, Ma XY, Chen Y, Yu B, Liao S, Huang H, Gao S., Free PMC Article | 06/15/2023 |
| FAM46C suppresses gastric cancer by inhibition of Wnt/beta-catenin. | FAM46C suppresses gastric cancer by inhibition of Wnt/beta-catenin.
Shi J, Zhu Q, Wu J, Zhu P. | 06/19/2021 |
| FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity. | FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity.
Kazazian K, Haffani Y, Ng D, Lee CMM, Johnston W, Kim M, Xu R, Pacholzyk K, Zih FS, Tan J, Smrke A, Pollett A, Wu HS, Swallow CJ., Free PMC Article | 06/19/2021 |
| The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis. | The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis.
Fucci C, Resnati M, Riva E, Perini T, Ruggieri E, Orfanelli U, Paradiso F, Cremasco F, Raimondi A, Pasqualetto E, Nuvolone M, Rampoldi L, Cenci S, Milan E. | 05/8/2021 |
| FAM46C controls antibody production by the polyadenylation of immunoglobulin mRNAs and inhibits cell migration in multiple myeloma. | FAM46C controls antibody production by the polyadenylation of immunoglobulin mRNAs and inhibits cell migration in multiple myeloma.
Herrero AB, Quwaider D, Corchete LA, Mateos MV, García-Sanz R, Gutiérrez NC., Free PMC Article | 05/1/2021 |
| FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy. | FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy.
Manfrini N, Mancino M, Miluzio A, Oliveto S, Balestra M, Calamita P, Alfieri R, Rossi RL, Sassoè-Pognetto M, Salio C, Cuomo A, Bonaldi T, Manfredi M, Marengo E, Ranzato E, Martinotti S, Cittaro D, Tonon G, Biffo S. | 02/6/2021 |
| Down-regulation of miR-10b represses cell vitality in osteosarcoma and is inversely associated with prognosis via interacting with FAM46C: Running title: MiR-10b/FAM46C axis modulates OS progression. | Down-regulation of miR-10b represses cell vitality in osteosarcoma and is inversely associated with prognosis via interacting with FAM46C: Running title: MiR-10b/FAM46C axis modulates OS progression.
Gao XZ, Xi XF, Zhang SP. | 11/21/2020 |
| Disruption of the family with sequence similarity 46, member C (FAM46C) gene promotes tumorigenicity of myeloma cells. Levels of phosphorylated Akt and its substrates increase both in vitro and in vivo in the FAM46C(-/-) cells compared to WT cells. Loss of FAM46C significantly activated serum-responsive genes while inactivating phosphatase and tensin homolog (PTEN)-related genes. | Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells.
Kanasugi J, Hanamura I, Ota A, Karnan S, Lam VQ, Mizuno S, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Takami A., Free PMC Article | 06/6/2020 |
| Low FAM46C expression is associated with myocardial dysfunction. | FAM46C inhibits lipopolysaccharides-induced myocardial dysfunction via downregulating cellular adhesion molecules and inhibiting apoptosis.
Tan J, Sun T, Shen J, Zhu H, Gong Y, Zhu H, Wu G. | 07/6/2019 |
| Study shows that FAM46C, a tumor suppressor for hepatocellular carcinoma, is important for the anti-proliferation and proapoptotic effects of norcantharidin. | FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells.
Zhang QY, Yue XQ, Jiang YP, Han T, Xin HL., Free PMC Article | 09/1/2018 |
| Reduced FAM46C mRNA expression levels were associated with Gastric Cancer. | FAM46C Serves as a Predictor of Hepatic Recurrence in Patients with Resectable Gastric Cancer.
Tanaka H, Kanda M, Shimizu D, Tanaka C, Kobayashi D, Hayashi M, Iwata N, Yamada S, Fujii T, Nakayama G, Sugimoto H, Fujiwara M, Niwa Y, Kodera Y. | 08/4/2018 |
| data strengthen the growing evidence that the FAM46C gene is involved in the pathogenesis of MM as a potential tumour suppressor, although its role remains to be clarified. | Compendium of FAM46C gene mutations in plasma cell dyscrasias.
Barbieri M, Manzoni M, Fabris S, Ciceri G, Todoerti K, Simeon V, Musto P, Cortelezzi A, Baldini L, Neri A, Lionetti M. | 02/17/2018 |
| FAM46C is a poly(A) polymerase and that loss of function of FAM46C drives multiple myeloma through the destabilisation of endoplasmic reticulum response transcripts. | The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma.
Mroczek S, Chlebowska J, Kuliński TM, Gewartowska O, Gruchota J, Cysewski D, Liudkovska V, Borsuk E, Nowis D, Dziembowski A., Free PMC Article | 01/20/2018 |
| FAM46C mutation as a contributor to myeloma pathogenesis and disease progression via perturbation in plasma cell differentiation and endoplasmic reticulum homeostasis. | Loss of FAM46C Promotes Cell Survival in Myeloma.
Zhu YX, Shi CX, Bruins LA, Jedlowski P, Wang X, Kortüm KM, Luo M, Ahmann JM, Braggio E, Stewart AK., Free PMC Article | 09/30/2017 |
| Data indicate that when cases with FAM46C deletion or mutation were considered together, they were strongly associated with impaired overall survival (OS) in the intensive treatment setting. | Mapping of chromosome 1p deletions in myeloma identifies FAM46C at 1p12 and CDKN2C at 1p32.3 as being genes in regions associated with adverse survival.
Boyd KD, Ross FM, Walker BA, Wardell CP, Tapper WJ, Chiecchio L, Dagrada G, Konn ZJ, Gregory WM, Jackson GH, Child JA, Davies FE, Morgan GJ, NCRI Haematology Oncology Studies Group., Free PMC Article | 06/16/2012 |