| Histones Methyltransferase NSD3 Inhibits Lung Adenocarcinoma Glycolysis Through Interacting with PPP1CB to Decrease STAT3 Signaling Pathway. | Histones Methyltransferase NSD3 Inhibits Lung Adenocarcinoma Glycolysis Through Interacting with PPP1CB to Decrease STAT3 Signaling Pathway.
Zhou Y, Peng X, Fang C, Peng X, Tang J, Wang Z, Long Y, Chen J, Peng Y, Zhang Z, Zhou Y, Tang J, Liao J, Xiao D, Tao Y, Shi Y, Liu S., Free PMC Article | 10/17/2024 |
| PP-1beta and PP-2Aalpha modulate cAMP response element-binding protein (CREB) functions in aging control and stress response through de-regulation of alphaB-crystallin gene and p300-p53 signaling axis. | PP-1β and PP-2Aα modulate cAMP response element-binding protein (CREB) functions in aging control and stress response through de-regulation of αB-crystallin gene and p300-p53 signaling axis.
Wang L, Zhang L, Gong XD, Fu JL, Gan YW, Hou M, Nie Q, Xiang JW, Xiao Y, Wang Y, Zheng SY, Yang L, Chen H, Xiang MQ, Liu Y, Li DW., Free PMC Article | 01/29/2022 |
| The expression and clinical prognostic value of protein phosphatase 1 catalytic subunit beta in pancreatic cancer. | The expression and clinical prognostic value of protein phosphatase 1 catalytic subunit beta in pancreatic cancer.
Hu L, Xu H, Wang X, Wu B, Chen F, Chen W, Gao Y, Zhong Z., Free PMC Article | 12/4/2021 |
| Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy. | Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy.
Motta M, Sagi-Dain L, Krumbach OHF, Hahn A, Peleg A, German A, Lissewski C, Coppola S, Pantaleoni F, Kocherscheid L, Altmüller F, Schanze D, Logeswaran T, Chahrokh-Zadeh S, Munzig A, Nakhaei-Rad S, Cavé H, Ahmadian MR, Tartaglia M, Zenker M. | 08/14/2021 |
| Noonan syndrome with loose anagen hair with variants in the PPP1CB gene: First familial case reported. | Noonan syndrome with loose anagen hair with variants in the PPP1CB gene: First familial case reported.
Huckstadt V, Chinton J, Gomez A, Obregon MG, Gravina LP. | 08/7/2021 |
| A case report of Noonan syndrome-like disorder with loose anagen hair 2 treated with recombinant human growth hormone. | A case report of Noonan syndrome-like disorder with loose anagen hair 2 treated with recombinant human growth hormone.
Zhou P, Zhu L, Fan Q, Liu Y, Zhang T, Yang T, Chen J, Cheng Q, Li T, Chen L. | 06/5/2021 |
| Integrative genomics analysis of eQTL and GWAS summary data identifies PPP1CB as a novel bone mineral density risk genes. | Integrative genomics analysis of eQTL and GWAS summary data identifies PPP1CB as a novel bone mineral density risk genes.
Zhai Y, Yu L, Shao Y, Wang J., Free PMC Article | 04/3/2021 |
| The association of MYPT1 with PP1cbeta was profoundly reduced in the presence of excess TIMAP, leading to proteasomal MYPT1 degradation. | TIMAP inhibits endothelial myosin light chain phosphatase by competing with MYPT1 for the catalytic protein phosphatase 1 subunit PP1cβ.
Wang X, Obeidat M, Li L, Pasarj P, Aburahess S, Holmes CFB, Ballermann BJ., Free PMC Article | 04/4/2020 |
| our experiments support that PPP1CB and KPC2 together inhibit the activity of HOXA2 by activating its nuclear export, but favored HOXA2 de-ubiquitination and stabilization thereby establishing a store of HOXA2 in the cytoplasm. | HOXA2 activity regulation by cytoplasmic relocation, protein stabilization and post-translational modification.
Deneyer N, Bridoux L, Bombled C, Pringels T, Bergiers I, Pyr Dit Ruys S, Vertommen D, Twizere JC, Rezsohazy R. | 01/18/2020 |
| PPP1CB mutation is associated with Noonan syndrome. | Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes.
Umeki I, Niihori T, Abe T, Kanno SI, Okamoto N, Mizuno S, Kurosawa K, Nagasaki K, Yoshida M, Ohashi H, Inoue SI, Matsubara Y, Fujiwara I, Kure S, Aoki Y. | 02/16/2019 |
| This report gives further support that this novel RASopathy-PPP1CB-related Noonan syndrome with loose anagen hair-shares great similarity to Noonan syndrome-like disorder with loose anagen hair, and expands the phenotypic spectrum by adding the cranial vault abnormality. | The recurrent PPP1CB mutation p.Pro49Arg in an additional Noonan-like syndrome individual: Broadening the clinical phenotype.
Bertola D, Yamamoto G, Buscarilli M, Jorge A, Passos-Bueno MR, Kim C. | 10/21/2017 |
| Missense mutations in PPP1CB are associated with a phenotype resembling NS-LAH. Based on this phenotype and PPP1CB's known role within the RAS/MAPK pathway, we think that this condition is a novel rasopathy, which may be provisionally termed "PPP1CB-related Noonan syndrome with loose anagen hair" (P-NS-LAH). | A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair.
Gripp KW, Aldinger KA, Bennett JT, Baker L, Tusi J, Powell-Hamilton N, Stabley D, Sol-Church K, Timms AE, Dobyns WB., Free PMC Article | 10/21/2017 |
| this study shows a pivotal role for PP1 in impeding IRF7-mediated IFN-alpha production in host immune responses | Protein phosphatase 1 abrogates IRF7-mediated type I IFN response in antiviral immunity.
Wang L, Zhao J, Ren J, Hall KH, Moorman JP, Yao ZQ, Ning S., Free PMC Article | 07/1/2017 |
| Our data suggest that our heterozygous de novo PPP1CB pathogenic variants are associated with syndromic intellectual disability. | De novo missense variants in PPP1CB are associated with intellectual disability and congenital heart disease.
Ma L, Bayram Y, McLaughlin HM, Cho MT, Krokosky A, Turner CE, Lindstrom K, Bupp CP, Mayberry K, Mu W, Bodurtha J, Weinstein V, Zadeh N, Alcaraz W, Powis Z, Shao Y, Scott DA, Lewis AM, White JJ, Jhangiani SN, Gulec EY, Lalani SR, Lupski JR, Retterer K, Schnur RE, Wentzensen IM, Bale S, Chung WK., Free PMC Article | 06/24/2017 |
| These results suggest a unique functional role for the PP1beta isoform in affecting cardiac contractile function | Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations.
Liu R, Correll RN, Davis J, Vagnozzi RJ, York AJ, Sargent MA, Nairn AC, Molkentin JD., Free PMC Article | 09/10/2016 |
| Findings show that PP1cbeta plays a role in endothelial cell migration through a mechanism involving the interplay of actin cytoskeleton proteins and focal adhesion molecules signaling. | Protein Phosphatase 1 Beta is Modulated by Chronic Hypoxia and Involved in the Angiogenic Endothelial Cell Migration.
Iacobazzi D, Garaeva I, Albertario A, Cherif M, Angelini GD, Caputo M, Ghorbel MT. | 02/13/2016 |
| PPP1C isoforms have distinct contribution to the outside-in alphaIIbbeta3 signalling-dependent functions in HEK293 alphaIIbbeta3 cells. | Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions.
Alrehani N, Pradhan S, Khatlani T, Kailasam L, Vijayan KV., Free PMC Article | 06/29/2013 |
| results indicate that SCN-iPS cells provide a useful disease model for SCN, and the activation of the Wnt3a/beta-catenin pathway may offer a novel therapy for SCN with ELANE mutation | Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in chronic lymphocytic leukemia.
Velusamy T, Palanisamy N, Kalyana-Sundaram S, Sahasrabuddhe AA, Maher CA, Robinson DR, Bahler DW, Cornell TT, Wilson TE, Lim MS, Chinnaiyan AM, Elenitoba-Johnson KS., Free PMC Article | 04/27/2013 |
| Studies suggest that any change in substrate specificity of the spinophilin : PP1 holoenzyme complex was probably due to direct modification of a PP1 substrate binding surface. | Structural basis for protein phosphatase 1 regulation and specificity.
Peti W, Nairn AC, Page R., Free PMC Article | 04/13/2013 |
| Studies indicate that the diversity of the PP1 interactome and the properties of the PP1 binding code account for the exquisite specificity of PP1 in vivo. | The PP1 binding code: a molecular-lego strategy that governs specificity.
Heroes E, Lesage B, Görnemann J, Beullens M, Van Meervelt L, Bollen M. | 04/13/2013 |
| Studies indicate that the Ser/Thr phosphatases PP1 and PP2A are responsible for the dephosphorylation and activation of Rb proteins. | PP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activation.
Kolupaeva V, Janssens V. | 04/13/2013 |
| Interaction between protein phosphatase 1 beta and myosin phosphatase (MYPT)1 results in exclusion of Nkx2.5 from the cell nucleus. | Myosin phosphatase modulates the cardiac cell fate by regulating the subcellular localization of Nkx2.5 in a Wnt/Rho-associated protein kinase-dependent pathway.
Ryan T, Shelton M, Lambert JP, Malecova B, Boisvenue S, Ruel M, Figeys D, Puri PL, Skerjanc IS., Free PMC Article | 03/9/2013 |
| These findings provide evidence for the involvement of a particular PP1 complex, PPP1R12A/PP1cdelta, in insulin signaling. | Protein phosphatase 1 regulatory subunit 12A and catalytic subunit δ, new members in the phosphatidylinositide 3 kinase insulin-signaling pathway.
Geetha T, Langlais P, Caruso M, Yi Z., Free PMC Article | 12/22/2012 |
| Protein phosphatase 1beta (PP1beta) is identified as a phosphatase for the cluster of phosphorylated threonines ((353)TTETQRT(359)) within the sst(2A) somatostatin receptor carboxyl terminus that mediates beta-arrestin binding using siRNA knock-down screening. | Rapid dephosphorylation of G protein-coupled receptors by protein phosphatase 1β is required for termination of β-arrestin-dependent signaling.
Pöll F, Doll C, Schulz S., Free PMC Article | 11/24/2012 |
| PPP1CB is over expressed in malignant melanoma. | Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma.
Sun D, Zhou M, Kowolik CM, Trisal V, Huang Q, Kernstine KH, Lian F, Shen B., Free PMC Article | 10/29/2011 |