| MARCH1 negatively regulates TBK1-mTOR signaling pathway by ubiquitinating TBK1. | MARCH1 negatively regulates TBK1-mTOR signaling pathway by ubiquitinating TBK1.
Li X, Cheng K, Shang MD, Yang Y, Hu B, Wang X, Wei XD, Han YC, Zhang XG, Dong MH, Yang ZL, Wang JQ., Free PMC Article | 07/30/2024 |
| MARCH-I: A negative regulator of dendritic cell maturation. | MARCH-I: A negative regulator of dendritic cell maturation.
Valizadeh M, Raoofian R, Homayoonfar A, Hajati E, Pourfathollah AA. | 03/6/2024 |
| Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain. | Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain.
Yu C, Bai Y, Tan W, Bai Y, Li X, Zhou Y, Zhai J, Xue M, Tang YD, Zheng C, Liu Q. | 02/9/2024 |
| MARCH1 silencing suppresses growth of oral squamous cell carcinoma through regulation of PHLPP2. | MARCH1 silencing suppresses growth of oral squamous cell carcinoma through regulation of PHLPP2.
Liu L, Guo B, Han Y, Xu S, Liu S. | 06/18/2022 |
| The Immune-Specific E3 Ubiquitin Ligase MARCH1 Is Upregulated during Human Cytomegalovirus Infection to Regulate Iron Levels. | The Immune-Specific E3 Ubiquitin Ligase MARCH1 Is Upregulated during Human Cytomegalovirus Infection to Regulate Iron Levels.
Martin M, Sandhu P, Kumar R, Buchkovich NJ., Free PMC Article | 05/14/2022 |
| 5-FU inhibits migration and invasion of CRC cells through PI3K/AKT pathway regulated by MARCH1. | 5-FU inhibits migration and invasion of CRC cells through PI3K/AKT pathway regulated by MARCH1.
Wang N, Yang L, Dai J, Wu Y, Zhang R, Jia X, Liu C., Free PMC Article | 09/4/2021 |
| ciRs-6 upregulates March1 to suppress bladder cancer growth by sponging miR-653. | ciRs-6 upregulates March1 to suppress bladder cancer growth by sponging miR-653.
Su Y, Feng W, Zhong G, Ya Y, Du Z, Shi J, Chen L, Dong W, Lin T., Free PMC Article | 10/24/2020 |
| MARCH1 has an important role in the development and progression of hepatocellular carcinoma. | MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-β-catenin pathways.
Xie L, Dai H, Li M, Yang W, Yu G, Wang X, Wang P, Liu W, Hu X, Zhao M., Free PMC Article | 07/18/2020 |
| Membrane-associated RING-CH (MARCH) 1 and 2 are MARCH family members that inhibit HIV-1 infection | Membrane-associated RING-CH (MARCH) 1 and 2 are MARCH family members that inhibit HIV-1 infection.
Zhang Y, Tada T, Ozono S, Yao W, Tanaka M, Yamaoka S, Kishigami S, Fujita H, Tokunaga K., Free PMC Article | 05/25/2019 |
| Results show that MARCH1 deficiency results in sex-specific changes in body weight, adiposity, and increases glucose clearance. Genetic association study for MARCH1 in type 2 diabetes risk in publicly-available datasets found evidence suggestive of association. These data show a link between immune function and diabetes implicating MARCH1 as a regulator of lipid metabolism and glucose tolerance in sex-specific manner. | The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner.
Bhagwandin C, Ashbeck EL, Whalen M, Bandola-Simon J, Roche PA, Szajman A, Truong SM, Wertheim BC, Klimentidis YC, Ishido S, Renquist BJ, Lybarger L., Free PMC Article | 03/23/2019 |
| found downstream sequence elements, present in the first coding exon of March-I in antigen-presenting cells (APCs), that confer regulation of March-I expression in activated APCs | A major isoform of the E3 ubiquitin ligase March-I in antigen-presenting cells has regulatory sequences within its gene.
Kaul S, Mittal SK, Roche PA., Free PMC Article | 01/19/2019 |
| March-I undergoes lysine-independent ubiquitination by an as yet unidentified E3 ubiquitin ligase that, together with Ube2D1, regulates March-I expression | Ubiquitin-conjugating enzyme E2 D1 (Ube2D1) mediates lysine-independent ubiquitination of the E3 ubiquitin ligase March-I.
Lei L, Bandola-Simon J, Roche PA., Free PMC Article | 01/12/2019 |
| MARCH1 ubiquitinates INSR to decrease cell surface INSR levels, but unlike other INSR ubiquitin ligases, MARCH1 acts in the basal state rather than after insulin stimulation. | MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels.
Nagarajan A, Petersen MC, Nasiri AR, Butrico G, Fung A, Ruan HB, Kursawe R, Caprio S, Thibodeau J, Bourgeois-Daigneault MC, Sun L, Gao G, Bhanot S, Jurczak MJ, Green MR, Shulman GI, Wajapeyee N., Free PMC Article | 09/8/2018 |
| MARCH1 functions as a tumor promoter by upregulating the NF-kappaB and the Wnt/b-catenin pathways, indicating that MARCH1 may be a therapeutic target for patients with ovarian cancer. | Silencing MARCH1 suppresses proliferation, migration and invasion of ovarian cancer SKOV3 cells via downregulation of NF-κB and Wnt/β-catenin pathways.
Meng Y, Hu J, Chen Y, Yu T, Hu L., Free PMC Article | 03/11/2017 |
| findings highlight the complex regulation of MARCH1 trafficking in the endocytic pathway as well as the intricate interactions between its cytoplasmic tails. | Identification of a novel motif that affects the conformation and activity of the MARCH1 E3 ubiquitin ligase.
Bourgeois-Daigneault MC, Thibodeau J. | 11/23/2013 |
| MARCH1 is capable of autoubiquitination, thus regulating its own expression. | Autoregulation of MARCH1 expression by dimerization and autoubiquitination.
Bourgeois-Daigneault MC, Thibodeau J. | 08/11/2012 |
| expression of MARCH1 or MARCH8 causes a drastic change CD98 trafficking after endocytosis | MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation.
Eyster CA, Cole NB, Petersen S, Viswanathan K, Früh K, Donaldson JG., Free PMC Article | 12/31/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The immunosuppressive effect of IL-10 on antigen presentation is mediated through induced expression of MARCH1. | Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes.
Thibodeau J, Bourgeois-Daigneault MC, Huppé G, Tremblay J, Aumont A, Houde M, Bartee E, Brunet A, Gauvreau ME, de Gassart A, Gatti E, Baril M, Cloutier M, Bontron S, Früh K, Lamarre D, Steimle V., Free PMC Article | 01/21/2010 |
| MARCH I is a major regulator of HLA-DR traffic, and its loss contributes to the acquisition of the potent immunostimulatory properties of mature human DCs. | MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.
De Gassart A, Camosseto V, Thibodeau J, Ceppi M, Catalan N, Pierre P, Gatti E., Free PMC Article | 01/21/2010 |