| A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer. | A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer.
Morgan MAJ, Popova IK, Vaidya A, Burg JM, Marunde MR, Rendleman EJ, Dumar ZJ, Watson R, Meiners MJ, Howard SA, Khalatyan N, Vaughan RM, Rothbart SB, Keogh MC, Shilatifard A., Free PMC Article | 04/16/2022 |
| DCAF14 promotes stalled fork stability to maintain genome integrity. | DCAF14 promotes stalled fork stability to maintain genome integrity.
Townsend A, Lora G, Engel J, Tirado-Class N, Dungrawala H., Free PMC Article | 01/29/2022 |
| Molecular double clips within RepID WD40 domain control chromatin binding and CRL4-substrate assembly. | Molecular double clips within RepID WD40 domain control chromatin binding and CRL4-substrate assembly.
Kim DK, Redon CE, Aladjem MI, Kim HK, Jang SM., Free PMC Article | 11/22/2021 |
| Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. | Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription.
Marenne G, Hendricks AE, Perdikari A, Bounds R, Payne F, Keogh JM, Lelliott CJ, Henning E, Pathan S, Ashford S, Bochukova EG, Mistry V, Daly A, Hayward C, INTERVAL, UK10K Consortium, Wareham NJ, O'Rahilly S, Langenberg C, Wheeler E, Zeggini E, Farooqi IS, Barroso I., Free PMC Article | 11/13/2021 |
| Discovery of a hidden transient state in all bromodomain families. | Discovery of a hidden transient state in all bromodomain families.
Raich L, Meier K, Günther J, Christ CD, Noé F, Olsson S., Free PMC Article | 06/12/2021 |
| PHIP drives glioblastoma motility, invasion, and angiogenesis. PHIP regulates expression of focal adhesion proteins and physically interacts with vinculin, mechanisms by which it promotes tumor cell motility and invasion. The presence of elevated PHIP copy number in distinct molecular glioblastoma subtypes provides additional support for its importance to glioblastoma biology. | PHIP drives glioblastoma motility and invasion by regulating the focal adhesion complex.
de Semir D, Bezrookove V, Nosrati M, Scanlon KR, Singer E, Judkins J, Rieken C, Wu C, Shen J, Schmudermayer C, Dar AA, Miller JR 3rd, Cobbs C, Yount G, Desprez PY, Debs RJ, Salomonis N, McAllister S, Cleaver JE, Soroceanu L, Kashani-Sabet M., Free PMC Article | 08/1/2020 |
| During mitosis, CRL4 dissociates from RepID and replaces it with RB Binding Protein 7 (RBBP7), which ubiquitinates the SAC mediator BUB3 to enable mitotic exit. | The RepID-CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation.
Jang SM, Nathans JF, Fu H, Redon CE, Jenkins LM, Thakur BL, Pongor LS, Baris AM, Gross JM, OʹNeill MJ, Indig FE, Cappell SD, Aladjem MI., Free PMC Article | 04/25/2020 |
| as elevated PHIP copy number appears to be selected for during the progression of primary to metastatic melanoma, these results confirm PHIP as a promising therapeutic target for melanoma. | Role of Elevated PHIP Copy Number as a Prognostic and Progression Marker for Cutaneous Melanoma.
Bezrookove V, Nosrati M, Miller JR 3rd, De Semir D, Dar AA, Vosoughi E, Vaquero E, Sucker A, Lazar AJ, Gershenwald JE, Davies MA, Schadendorf D, Kashani-Sabet M., Free PMC Article | 11/9/2019 |
| The replication initiation determinant protein PHIP modulates replication by recruiting CUL4 to chromatin. | The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin.
Jang SM, Zhang Y, Utani K, Fu H, Redon CE, Marks AB, Smith OK, Redmond CJ, Baris AM, Tulchinsky DA, Aladjem MI., Free PMC Article | 12/22/2018 |
| These results provide further support for PHIP as a molecular prognostic marker of melanoma, and reveal a significant linkage between PHIP levels and ulceration. | Prognostic impact of PHIP copy number in melanoma: linkage to ulceration.
Bezrookove V, De Semir D, Nosrati M, Tong S, Wu C, Thummala S, Dar AA, Leong SPL, Cleaver JE, Sagebiel RW, Miller JR 3rd, Kashani-Sabet M., Free PMC Article | 04/12/2014 |
| The PHIP gene resides on 6q14.1, and although 6q loss has been observed in melanoma, the PHIP locus was preserved in melanoma cell lines and patient samples, and its overexpression was an independent adverse predictor of survival in melanoma patients. | Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis.
De Semir D, Nosrati M, Bezrookove V, Dar AA, Federman S, Bienvenu G, Venna S, Rangel J, Climent J, Meyer Tamgüney TM, Thummala S, Tong S, Leong SP, Haqq C, Billings P, Miller JR 3rd, Sagebiel RW, Debs R, Kashani-Sabet M., Free PMC Article | 07/14/2012 |